*Corresponding Author: Ankit Thakur, Department of Pharmacy Practice, Samskruti College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, India.

Received: December 19, 2023; Published: February 18, 2024

Abstract

The ocular surface is the outermost part of the visual system can experience physical or chemical damage from external or internal factors such as thermal harm, infectious pathogens, and burns, Steven Johnson Syndrome or, other autoimmune diseases. Limbal cells possess stem cell qualities and regenerative capabilities due to their capacity for differentiation. The regeneration of corneal wounds involves a multifaceted process encompassing cell death, proliferation, migration, differentiation, and remodeling of the extracellular matrix. Among various therapies for corneal regeneration, stem cell therapy stands out as the most promising due to its rapid recovery from infections. Although still in its early stages, interventions for treating corneal abnormalities are underway. These interventions involve the use of both viral and non-viral vectors to introduce genes into the cornea, employing in vivo, ex vivo, and in vitro methods. This review primarily focuses on the latest advancements utilizing biological modulators like gene therapy, signaling inhibitors, microRNA, and Nano formulations. Additionally, the paper concentrates on the latest therapies utilizing stem cells and advancements in the ocular drug delivery system, aiming to enhance potential therapies for the future treatment of ocular diseases.

Keywords: Stem Cells; Rock Inhibitor; Gene Therapy; Corneal Regeneration; Micro RNA; Corneal Damage

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Citation

Citation: M Sanjana and Ankit Thakur. “Different Types of Therapies in Corneal Regeneration".Acta Scientific Paediatrics 7.3 (2024): 11-16.

Copyright

Copyright: © 2024 M Sanjana and Ankit Thakur. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.