Acta Scientific Paediatrics (ASPE)

Review Article Volume 6 Issue 10

Anti-Inflammatory Properties of Human Milk, An Ancient but Novel Concept

Enrique Chacón-Cruz1* and Eduardo Antonio Lara-Pérez2

1Independent Researcher/Consultant in Houston, Texas, USA and the Institute for Global Health, University of Siena, Italy
2Pediatrician, Retired from IMSS, Full Academician (Mexican Academy of Pediatrics) President and CEO of the Medical Fraternity for Health A.C. "Doctors United for Mexico"

*Corresponding Author: Enrique Chacón-Cruz, Independent Researcher/Consultant in Houston, Texas, USA and the Institute for Global Health, University of Siena, Italy.

Received: March 15, 2023; Published: November 27, 2023

Abstract

As an evolutionary process acknowledging all its countless benefits, human milk (HM), has led to many types of studies: experimental (in vitro and in vivo), cohorts, etc., all with outcomes consistent on infant’s protection. HM effects as neuroprotective, anti-infective, promotor of infant’s development, and many more are known by everyone. The primary aim of this review is to inform the reader about this property in HM: Anti-inflammation. The document starts with a brief anthropological/historical glance of this property, following with in vitro and in vivo experimental studies done both in experimental animals, as well as in human cells, with emphasis on studies done by one of the co-authors. At the end, is expected that the reader recognizes HM anti-inflammatory effects as essential in the protection process of the infant against both infectious and non-infectious injuries, as well as to finally understand the leading mechanisms of action of HM anti-inflammation, such as its effects on neutrophils (polarization, phagocytosis, intra and extracellular response to calcium), on other inflammatory cells, interleukins, among others.

Keywords: Anti-Inflammatory; Human Milk, Breastfeeding

References

  1. Feachem RG and Koblinsky MA. “Interventions for the control of diarrhoeal diseases among young children: promotion of breastfeeding”. Bulletin of the World Health Organization 62 (1984): 271-291.
  2. Morrow AL and Pickering LK. “Human milk protection against diarrheal disease”. Seminars in Pediatric Infectious Diseases 5 (1994): 36-42.
  3. Howie PW., et al. “Protective effect of breastfeeding against infection”. British Medical Journal 300 (1990): 11-16.
  4. Cunningham AS and Jelliffe EFP. “Breastfeeding and health in the 1980’s: a global epidemiologic review”. The Journal of Pediatrics 118 (1991): 659-666.
  5. Beaudry M., et al. “Relation between infant feeding and infections during the first six months of life”. The Journal of Pediatrics 126 (1995): 191-197.
  6. Owen MJ., et al. “Relation of infant feeding practices, cigarette smoke exposure, and group child care to the onset and duration of otitis media with effusion in the first two years of life”. The Journal of Pediatrics 123 (1993): 702-711.
  7. Duncan B., et al. “Exclusive breastfeeding for at least 4 months protection against otitis media”. Pediatrics 91 (1993): 867-872.
  8. Wright AL., et al. “Breastfeeding and lower respiratory tract illness in the first year of life”. British Medical Journal 299 (1989): 946-949.
  9. Chen Y., et al. “Artificial feeding and hospitalization in the first 18 months of life”. Pediatrics 81 (1988): 58-62.
  10. Victora CG., et al. “Evidence for protection by breastfeeding against infant deaths from infectious diseases in Brazil”. Lancet 2 (1987): 319-322.
  11. Forman MR., et al. “The Pima infant feeding study: breastfeeding and respiratory infection during the first year of life”. International Journal of Epidemiology 13 (1984): 447-453.
  12. Cunningham AS. “Morbidity in breast-fed and artificially fed infants”. The Journal of Pediatrics 95 (1977): 685-689.
  13. Frank AL., et al. “Breastfeeding and respiratory virus infection”. Pediatrics 70 (1982): 239-245.
  14. Arnold C., et al. “Day care attendance and other risk factors for invasive Haemophilus influenzae type b disease”. American Journal of Epidemiology 138 (1993): 333-340.
  15. Cochi SL., et al. “Primary invasive Haemophilus influenzae type b disease: a population-based assessment of risk factors”. The Journal of Pediatrics 108 (1986): 887-896.
  16. Istre GR., et al. “Risk factors for primary Haemophilus influenzae disease: increased risk from day care attendance and school-aged household members”. The Journal of Pediatrics 106 (1985): 190-195.
  17. Takala AK., et al. “Risk factors of invasive Haemophilus inflenzae type b disease among children in Finland”. The Journal of Pediatrics 115 (1989): 694-701.
  18. Caplan MS and MacKendrick W. “Necrotizing enterocolitis: a review of pathogenic mechanisms and implications for prevention”. Pediatric Pathology 13 (1993): 357-369.
  19. Lucas A and Cole TJ. “Breast milk and necrotizing enterocolitis”. Lancet 336 (1990): 1519-1523.
  20. Pickering LK and Morrow AL. “Factors in human milk that protect against diarrheal disease”. Infection 21 (1993): 355-357.
  21. Anderson B., et al. “Inhibition of attachment of Streptococcus Pneumoniae and Haemophilus Influenzae by human milk and receptor oligosaccharides”. The Journal of Infectious Diseases 153 (1986): 232-237.
  22. Plaut AG., et al. “Growth of Haemophilus influenzae in human milk: synthesis, distribution, and activity of IgA protease as determined by study of IgA+ and mutant IgA-cells”. The Journal of Infectious Diseases 166 (1992): 43-52.
  23. Kauppi M., et al. “Anti-capsular polysaccharide antibodies reduce nasopharyngeal colonization by Haemophilus influenzae type b in infant rats”. The Journal of Infectious Diseases 167 (1993): 365-371.
  24. Davies J., et al. “Binding of Haemophilus influenzae to purified mucins mucins from the human respiratory tract”. Infect Immunity 63 (1995): 2485-2492.
  25. Pullan CR., et al. “Breastfeeding and respiratory sincytial virus infection”. British Medical Journal 281 (1980): 1034-1036.
  26. Goldman AS. “The immune system of human milk: antimicrobial, anti-inflamatory and immunomodulating properties”. The Pediatric Infectious Disease Journal 12 (1993): 664-671.
  27. Ishizaka S., et al. “Antibody production system modulated by oral administration of human milk and TGF-b”. Cellular Immunology 159 (1994): 77-84.
  28. Benno Y., et al. “The intestinal microflora of infants: composition of fecal flora in breast fed and bottle fed infants”. Microbiology and Immunology 28 (1984): 975-986.
  29. Goldman AS., et al. “Anti-inflammatory properties of human milk”. Acta Paediatrica Scandinavica 75 (1985): 689-695.
  30. Pabst HF. “Immunomodulation by breast-feeding”. The Pediatric Infectious Disease Journal 16 (1997): 991-995.
  31. Buescher ES and McIlheran SM. “Colostral antioxidants: separation and characterization of two activities in human colostrum”. Journal of Pediatric Gastroenterology and Nutrition 14 (1992): 47-56.
  32. Garofalo R., et al. “Interleukin-10 in human milk”. Pediatric Research 37 (1995): 444-449.
  33. Murphey DK and Buescher ES. “Human colostrums has anti-inflammatory activity in a rat subcutaneous air pouch model if inflammation”. Pediatric Research 34 (1993): 208-212.
  34. Grazioso CF., et al. “Antiinflamatory effects of human milk on chemically induced colitis in rats”. Pediatric Research 42 (1997): 639-643.
  35. Buescher ES and Malinowska I. “Soluble receptors and cytokine antagonists in human milk”. Pediatric Research6 (1996): 839-844.
  36. Grazioso CF and Buescher ES. “Inhibition of neutrophil function by human milk”. Cellular Immunology 168 (1996): 125-132.
  37. Buescher ES and McIlheran SM. “Polymorphonuclear leukocytes and human colostrums: effects in vivo and in vitro exposure”. Journal of Pediatric Gastroenterology and Nutrition 17 (1993): 424-433.
  38. Keeney SE., et al. “Activated neutrophils and neutrophil activators in human milk: increased expression of CD11b and decreased expression of L-selectin”. Journal of Leukocyte Biology 54 (1993): 97-104.
  39. Chacon-Cruz E., et al. “Human milk effects on neutrophil calcium metabolism: blockade of calcium influx after agonist stimulation”. Pediatric Research 46 (1996): 200-207.
  40. Chacon-Cruz E., et al. “Release and depletion of internal Ca++ stores by human milk is associated with decreased physiologic responses in human polymorphonuclear leukocytes”. Presentación tipos póster/oral en el Symposium of Human Milk of the XVII Scientific Congress of the European Society for Paediatric Haematology and Immunology, Washington, D.C., Mayo (1999): 11-12.
  41. Chacon-Cruz E., et al. “Human milk induces calcium transient responses, cellular activation and functional suppression in human polymorphonuclear leukocytes”. Presentación tipos póster/oral en el Symposium of Human Milk of the XVII Scientific Congress of the European Society for Paediatric Haematology and Immunology, Washington, D.C Mayo (1999): 11-12.
  42. Goldman AS., et al. “Evolution of immunologic functions of the mammary gland and the postnatal development of immunity”. Pediatric Research 43 (1998): 155-162.

Citation

Citation: Enrique Chacón-Cruz and Eduardo Antonio Lara-Pérez. “Anti-Inflammatory Properties of Human Milk, An Ancient but Novel Concept".Acta Scientific Paediatrics 6.10 (2023): 44-48.

Copyright

Copyright: © 2023 Enrique Chacón-Cruz and Eduardo Antonio Lara-Pérez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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