Acta Scientific Paediatrics (ASPE)

Editorial Volume 6 Issue 10

Food Protein-Induced Proctocolitis: A Unique Subtype of Gastrointestinal Non-IgE-mediated Food Allergy

Nilton Carlos Machado* and Mary de Assis Carvalho

Pediatric Gastroenterology, Hepatology and Nutrition Division, Department of Pediatrics, Botucatu Medical School - São Paulo State University, Botucatu, Sao Paulo, Brazil

*Corresponding Author: Nilton Carlos Machado, Associate Professor of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Botucatu Medical School – UNESP, Botucatu, São Paulo, Brazil.

Received: October 30, 2023; Published: November 01, 2023


Food allergy (FA) is an abnormal clinical reaction to proteins in which immunologically mediated mechanisms are implicated [1]. Certainly, FA is a major global health problem, and its geographic distribution may be linked to genetic, environmental, lifestyle, and dietary factors [2]. Pediatricians are the first specialists to be sought out by family members of children suspected of having FA. Therefore, they must be trained in the principles of diagnosis and carry out appropriate referrals when necessary [3-5]. Although more than 160 foods can cause allergic reactions, eight are considered significant allergens (cow's milk, soy, egg, wheat, fish and shellfish, peanuts, and tree nuts).


  1. Sicherer Scott H and Hugh A Sampson. “Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management”. The Journal of Allergy and Clinical Immunology1 (2018): 41-58.
  2. Genuneit J., et al. “Task Force' Overview of systematic reviews in allergy epidemiology (OSRAE)' of the EAACI Interest Group on Epidemiology. Overview of systematic reviews in allergy epidemiology”. Allergy 72 (2017): 849-856.
  3. Boyce JA., et al. “Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report”. The Journal of Allergy and Clinical Immunology6 (2010): S1-58.
  4. Burks AW., et al. “NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population”. Pediatrics 128 (2011): 955-965.
  5. Gupta RS., et al. “The economic impact of childhood food allergy in the United States”. JAMA Pediatrics 167 (2011): 1026-1031.
  6. Sicherer SH and Sampson HA. “Food allergy”. The Journal of Allergy and Clinical Immunology2 (2010): S116-125.
  7. Mansoor DK and Sharma HP. “Clinical presentations of food allergy”. Pediatric Clinics of North America 2 (2011): 315-326.
  8. Leonard SA. “Non-IgE-mediated adverse food reactions”. Current Allergy and Asthma Reports 12 (2017): 84.
  9. Xanthacos SA., et al. “Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: a prospective cohort study”. Journal of Pediatric Gastroenterology and Nutrition 41 (2005): 16-22.
  10. Arvola T., et al. “Rectal bleeding in infancy: clinical, allergological, and microbiological examination”. Pediatrics 117 (2006): e760-e768.
  11. Elizur A., et al. “Cow's milk associated rectal bleeding: a population-based prospective study”. Pediatric Allergy and Immunology 23 (2012): 766-770.
  12. Caubet JC., et al. “Non- IgE-mediated gastrointestinal food allergies in children”. Pediatric Allergy and Immunology1 (2017): 6-17.
  13. Dehghani SM., et al. “A survey on rectal bleeding in children, a report from Iran”. Turkish Journal of Medical Sciences 48 (2018): 412-418.
  14. Lake AM., et al. “Dietary protein-induced colitis in breastfed infants”. Journal of Pediatrics 101 (1981): 906-910.
  15. Fox VL. “Gastrointestinal bleeding in infancy and childhood”. Gastroenterology Clinics of North America 1 (2000): 37-66.
  16. Eigenmann PA. “Mechanisms of food allergy”. Pediatric Allergy and Immunology 20 (2009): 5-11.


Citation: Nilton Carlos Machado and Mary de Assis Carvalho. “Food Protein-Induced Proctocolitis: A Unique Subtype of Gastrointestinal Non-IgE- mediated Food Allergy".Acta Scientific Paediatrics 6.10 (2023): 21-23.


Copyright: © 2023 Nilton Carlos Machado and Mary de Assis Carvalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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