Huseynova IE*, Hasanov AQ, Mammadova FM and Gafarov IA

Azerbaijan Medical University, Department of Children's Diseases II, Department of Medical Physics and Informatics, Azerbaijan

*Corresponding Author: Huseynova IE, Azerbaijan Medical University, Department of Children's Diseases II, Department of Medical Physics and Informatics, Azerbaijan.

Received: July 25, 2023; Published: September 13, 2023

Abstract

The purpose of the study was to determine the cytokine profile that plays a role in the pathogenesis of acute respiratory diseases of various etiologies in children and to analyze the obtained results. 89 patients diagnosed with acute respiratory disease of moderate severity (age 1 month-17 years) were involved in the study. For comparison, 35 children formed the control group. The gender distribution revealed that there were 54 (60.7%) boys and 35 (39.3%) girls in the main group, and 17 (48.6%) boys and 18 (51.4%) girls in the control group.

The children included in the main group were divided into two groups based on the diagnosis: Group I was diagnosed with ARDs (53(59.6%)), Group II (36(40,4%)) was diagnosed with ARDs complicated by other upper respiratory tract diseases (bronchitis, laryngotracheitis, laryngitis, tracheitis).

In the clinical examination, different levels of upper respiratory tract damage syndrome, catarrhal symptoms, fever, cough, rhinitis were more manifested during ARDs.

During the study, the level of pro-inflammatory cytokines (IL-21 and γ- INF, IL-1β, IL-6, IL-18) in the blood serum of patients with ARDs differed depending on the clinical course of the disease in the acute period compared to the control group. Compared to group I, the level of IL-21 and IL-6 increased significantly in group II. The study of the level of pro-inflammatory cytokines in the blood serum of patients with ARDs allows to determine the course and severity of the inflammatory process.

 Keywords: Acute Respiratory Diseases; Children; Cytokines

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Citation

Citation: Huseynova IE., et al. “ Clinical and Laboratory Characteristics of Acute Respiratory Diseases in Children”. Acta Scientific Paediatrics 6.8 (2023): 20-29.

Copyright

Copyright: © 2023 Huseynova IE., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.