Hasan Mahmud Rumi¹*, Syed Shafi Ahmed², Salahuddin Mahmud³, Sohely Akter⁴ and Muhammed Nurul Islam Shikdar⁵

¹MD (Paediatrics), Assistant Professor, Department of Paediatrics, Tairunnessa Memorial Medical College and Hospital, Bangladesh
²PhD Professor and Head, Department of Paediatric Gastroenterology, Hepatology and Nutrition, Bangladesh Shishu Hospital and Institute, Bangladesh
³MD (Paediatrics), Associate Professor, Department of Paediatric Gastroenterology, Hepatology and Nutrition, Bangladesh Shishu Hospital and Institute, Bangladesh
⁴Assistant Professor (CC), Department of Paediatrics, Tairunnessa Memorial Medical College and Hospital, Bangladesh
⁵Assistant Professor, Department of Paediatrics, Aichi Medical College, Bangladesh

*Corresponding Author: Hasan Mahmud Rumi, MD (Paediatrics), Assistant Professor, Department of Paediatrics, Tairunnessa Memorial Medical College and Hospital, Bangladesh. Email: Rumidrhasanrumi@gmail.com.

Received: June 13, 2023; Published: June 22, 2023

Abstract

Background: Optimizing outcomes in biliary atresia (BA) requires timely diagnosis. Despite early hepaticoportoenterostomy, BA has still been the most common indication for paediatric liver transplantation. So early diagnosis is extremely important for management. Ultrasonography and hepatobiliary scintigraphy are two major diagnostic methods for the diagnosis of biliary atresia.

Aim of the Study: To determine the accuracy of ultrasonography and hepatobiliary scintigraphy for the diagnosis of biliary atresia.

Material and Methods: The present study was a cross-sectional observational conducted in the Department of Pediatric Gastroenterology, Hematology and Nutrition, Dhaka Shishu (Children) Hospital, Dhaka City from March 2018 to August 2019. Data were processed and analyzed using computer software SPSS statistical package, version 23 (SPSS Inc., Chicago, IL, USA) for Windows XP. Data were expressed as numbers and percentages for qualitative variables and median range (minimum and maximum) for quantitative variables. To compare categorical variables between groups of patients with neonatal cholestasis, the chi-square (χ2) test or Fisher’s exact test was used. Fisher’s exact test was used instead of the χ2-test when the expected value in any one contingency cell was ≤5. Student t-test was used for continuous variables. Validity tests were done for ultrasonography and hepatobiliary scintigraphy with liver biopsy confirmed biliary atresia. A p-value < 0.05 was considered to be statistically significant in all the analyses.

Results: Ultrasonography, hepatobiliary scintigraphy and liver biopsy findings of 50 neonatal cholestasis cases were studied where Hepatobiliary scintigraphy had the highest sensitivity of 90.5% but low specificity of 44.8%. The sensitivity and specificity of USG for the diagnosis of BA were found to be 81.0% and 65.5% respectively in this study. Diagnostic accuracy of USG and hepatobiliary scintigraphy for diagnosis of BA was 72.0% and 64.0% respectively.

Conclusion: This study showed that hepatobiliary scintigraphy had high sensitivity but low specificity for diagnosing biliary atresia. The diagnostic accuracy of ultrasonography is more than hepatobiliary scintigraphy for diagnosing biliary atresia.

 Keywords: Biliary Atresia; Ultrasonography; Hepatobiliary Scintigraphy; Diagnostic Accuracy

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Citation

Citation: Hasan Mahmud Rumi., et al. “Accuracy of Ultrasonography and Hepatobiliary Scintigraphy for the Diagnosis of Biopsy Proven Biliary Atresia”. Acta Scientific Paediatrics 6.7 (2023): 17-22.

Copyright

Copyright: © 2023 Hasan Mahmud Rumi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.