Acta Scientific PAEDIATRICS (ISSN: 2581-883X)

Research Article Volume 6 Issue 7

Association between Antiepileptic Drugs and Therapy with Bone Mineral Density (BMD)

Enamul Kabir1*, Shah Mohammad Bodruddoza2 and Masuma After3

1Medical Officer, Department of Paediatrics, Magura, Bangladesh
2Consultant (Paediatrics), Faridpur General Hospital, Faridpur, Bangladesh
3Senior Consultant (Paediatrics), Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

*Shared Authorship: Enamul Kabir, Medical Officer, Department of Paediatrics, Magura, Bangladesh.

Received: May 17, 2023; Published: June 05, 2023

Abstract

Background: Epilepsy is a common medical and social disorder characterized by epileptic seizures. These seizures occur due to disruptions of electrical signals in the brain. Epilepsy also characterized by the neurobiologic, cognitive, psychological, and social consequences of this condition.

Aim of the study: The aim of the study was to find out the Association between Antiepileptic Drugs and Therapy with Bone Mineral Density (BMD).

Methods: This study was conducted in the Saleh Child Development and Disability Management Center (SCDDMC), of Institute of Child and Mother Health (ICMH) Matuail, Dhaka. A total of 31 childrens age ranged 5-15 years diagnosed as epilepsy on the basis of both clinical examination and investigation (EEG) receiving antiepileptic drugs (AEDS) for at least two years were recruited in this study.

Results: The mean serum calcium was 9.22 ± 0.78 mg/dl, and the mean BMD score of the spine was 0.66 ± 0.14. The mean BMD of the left femur neck was 0.66 ± 0.15.The name and combination of drugs used in the study children. It was found that 35.5% of the children received PB alone, followed by 16.1% receiving VPA alone. 12.9% received PB with VPA, 12.9% received PB with VPA with others, 9.7% received VPA with NTZ, and 6.5% received PB with VPA with NTZ and VPA alone. Table 7 demonstrated the association between the duration of drugs and the BMD Z-score of the study children.

Conclusion: AEDs decreased bone mineral density due to long term use as mono-therapy or polytherapy. The assessment of BMD among children with epilepsy receiving long term AEDs is essential.

Keywords:Epilepsy; Bone Mineral Density (BMD); Antiepileptic Drugs

References

  1. Berry SD., et al. “Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture”. JAMA 12 (2013): 1256-1262.
  2. Gissel T., et al. “Adverse effects of antiepileptic drugs on bone mineral density in children”. Expert Opinion on Drug Safety 3 (2007): 267-278.
  3. Verrotti A., et al. “Bone and calcium metabolism and antiepileptic drugs”. Clinical Neurology and Neurosurgery 1 (2010): 1-10.
  4. Meier C and Kraenzlin ME. “Antiepileptics and bone health”. Therapeutic Advances in Musculoskeletal Disease5 (2011): 235-243.
  5. Serin HM., et al. “The bone mineral content alterations in pediatric patients are medicated with levetiracetam, valproic acid, and carbamazepine”. Epilepsy and Behavior 51 (2015): 221-224.
  6. Petty SJ., et al. “Osteoporosis associated with epilepsy and the use of anti-epileptics—a review”. Current Osteoporosis Reports 14 (2016): 54-65.
  7. Rahman M S., et al. “Association of antiepileptic drug therapy with bone mineral density among epileptic patients in Bangladesh”. Journal of Neurology and Neuroscience2 (2019): 1-6.
  8. Ahmed S., et al. “Antiepileptic drug therapy and bone mineral density among epileptic patients attending a tertiary care hospital in Bangladesh”. International Journal of Health Sciences (2020).
  9. Tolaymat A., et al. “Diagnosis and management of childhood epilepsy”. Current Problems in Pediatric and Adolescent Health Care1 (2015): 3-17.
  10. Ross PD., et al. “Pre-existing fractures and bone mass predict vertebral fracture incidence in women”. Annals of Internal Medicine11 (1991): 919-923.
  11. Hasaneen B., et al. “Bone mineral status in children with epilepsy: biochemical and radiologic markers”. Journal of Pediatric Neurosciences2 (2017): 138.
  12. Osman NM., et al. “Bone mineral density evaluation o epileptic children on anti-epileptic medications”. The Egyptian Journal of Radiology and Nuclear Medicine4 (2017): 1083-1090.
  13. Babtain F., et al. “Is parental consanguinity a risk factor for epilepsy? A cases-control study assessing epilepsy risks in Southern Saudi Arabia”. Al-Azhar Assiut Medical Journal 13 (20153): 60-66.
  14. Cansu A., et al. “Prevalence of some risk factors in children with epilepsy compared to their controls”. Seizure4 (2007): 338-344.
  15. Thomas S., et al. “Brief report: prevalence of co-occurring epilepsy and autism spectrum disorder: the US National Survey of Children’s Health 2011–2012”. Journal of Autism and Developmental Disorders 47 (2017): 224-229.
  16. Fong CY., et al. “Vitamin D deficiency and its risk factors in Malaysian children with epilepsy”. Epilepsia 8 (2016): 1271-1279.
  17. Atugonza R., et al. “Multiple anti-epileptic drug use in children with epilepsy in Mulago hospital, Uganda: a cross sectional study”. BMC Pediatrics 16.1 (2016): 1-10.
  18. Sarhan EM., et al. “Evidence for efficacy of combination of antiepileptic drugs in treatment of epilepsy”. Journal of Neurology Research6 (2016): 267-276.

Citation

Citation: Enamul Kabir., et al. “Association between Antiepileptic Drugs and Therapy with Bone Mineral Density (BMD)". Acta Scientific Paediatrics 6.7 (2023): 11-16.

Copyright

Copyright: © 2023 Enamul Kabir., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor1.197

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is September 30, 2023.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US