Acta Scientific Paediatrics (ISSN: 2581-883X)

Research Article Volume 6 Issue 6

Association between Antiepileptic Drugs and Therapy with Bone Mineral Density (BMD)

Enamul Kabir1*, Shah Mohammad Bodruddoza2 and Masuma After3

1Medical Officer, Department of Paediatrics, 250 Bed District Hospital, Magura, Bangladesh
2Consultant (Paediatrics), Faridpur General Hospital, Faridpur, Bangladesh
3Senior Consultant (Paediatrics), Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

*Corresponding Author: Enamul Kabir, Medical Officer, Department of Paediatrics, 250 Bed District Hospital, Magura, Bangladesh.

Received: May 08, 2023; Published: May 17, 2023


Background: Epilepsy is a common medical and social disorder characterized by epileptic seizures. These seizures occur due to disruptions of electrical signals in the brain. Epilepsy also characterized by the neurobiologic, cognitive, psychological, and social consequences of this condition.

Aim of the study: The aim of the study was to find out the Association between Antiepileptic Drugs and Therapy with Bone Mineral Density (BMD).

Methods: This study was conducted in the Saleh Child Development and Disability Management Center (SCDDMC), of Institute of Child and Mother Health (ICMH) Matuail, Dhaka. A total of 31 childrens age ranged 5-15 years diagnosed as epilepsy on the basis of both clinical examination and investigation (EEG) receiving antiepileptic drugs (AEDS) for at least two years were recruited in this study.

Result: The mean serum calcium was 9.22 ± 0.78 mg/dl, and the mean BMD score of the spine was 0.66 ± 0.14. The mean BMD of the left femur neck was 0.66 ± 0.15. The name and combination of drugs used in the study children. It was found that 35.5% of the children received PB alone, followed by 16.1% receiving VPA alone. 12.9% received PB with VPA, 12.9% received PB with VPA with others, 9.7% received VPA with NTZ, and 6.5% received PB with VPA with NTZ and VPA alone. Table 7 demonstrated the association between the duration of drugs and the BMD Z-score of the study children.

Conclusion: AEDs decreased bone mineral density due to long term use as mono-therapy or polytherapy. The assessment of BMD among children with epilepsy receiving long term AEDs is essential.

 Keywords: Bone Mineral Density (BMD); Epilepsy


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Citation: Enamul Kabir., et al. “Association between Antiepileptic Drugs and Therapy with Bone Mineral Density (BMD)”. Acta Scientific Paediatrics 6.6 (2023): 04-10.


Copyright: © 2023 Enamul Kabir., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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