Arbari Saha*

Department of Neonatology, BSMMU, Dhaka, India

*Corresponding Author: Saha, Department of Neonatology, BSMMU, Dhaka, India.

Received: June 13, 2023; Published: February 28, 2023

Abstract

Thrombocytopenia is the commonest hematological abnormality encountered in the neonatal intensive care unit (NICU). Thrombocytopenia is more common in certain risk group. This prospective– observational study was conducted among 78 consecutive at risk neonates admitted in NICU, Bangabandhu Sheikh Mujib Medical University (BSMMU). Platelet count was done in all at risk neonates at enrollment and less than 1,50,000/cu mm was taken as the cut off point for determining thrombocytopenia. If initial platelet count was low then platelet count was done every alternate day till discharge or normal. If initial platelet count revealed normal, then babies were followed up clinically whether they develop any further risk condition for developing thrombocytopenia. During the period from enrollment to discharge, if any baby develops thrombocytopenia at any time then baby was defined as thrombocytopenic. Among 78 pts, initial platelet count was low in 8 patients (10.2%) and in 29 (37.1%) pts subsequently developed risk factor and platelet count was done in those patients. Among them, 23 patients revealed thrombocytopenia. Overall 31 (39.7%) patients found thrombocytopenic among 78 at risk neonates. Pregnancy induced hypertension (PIH), neonatal sepsis, small for gestational age (SGA) and intra uterine growth restriction (IUGR), prematurity, Necrotizing Enterocolitis (NEC) were significantly associated with thrombocytopenia (p = <0.05). Sepsis and NEC were found to be independent risk factor for thrombocytopenia. Regarding outcome, length of hospital stay was significantly more in thrombocytopenic patients than non-thrombocytopenic patients (p = <0.037). Death rate was also higher in thrombocytopenic patients in comparison to non- thrombocytopenic patients (p value- 0. 007).

Keywords: Frequency; Thrombocytopenia; Neonates; Observational Study

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Citation

Citation: Arbari Saha. “Frequency and Outcome of Thrombocytopenia in Neonates who are at Risk of Developing Thrombocytopenia - A Prospective-Observational Study". Acta Scientific Paediatrics 6.3 (2023): 28-34.

Copyright

Copyright: © 2023 Arbari Saha. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.