Adriana Costa*, Sara Completo and Paula Correia

Department of Child and Youth, Hospital Professor, Doutor Frenando Fonseca, EPE, Portugal

*Corresponding Author: Adriana Costa, Department of Child and Youth, Hospital Professor, Doutor Frenando Fonseca, EPE, Portugal.

Received: August 24, 2022; Published: November 16, 2022

Abstract

Introduction: Pediatric invasive disease (PID) is confirmed by isolation of a microorganism from a normally sterile site. The incidence of infection due to multi-drug resistant (MDR) bacteria is increasing worldwide, which threatens the effective treatment of infections. This study aims to characterize PID during 10-years in a Portuguese hospital: morbimortality, risk factors and antimicrobial susceptibility.

Methods: Descriptive retrospective study of PID in children aged between 28 days and 18 years old, attended in a pediatric department from 2010 to 2020.

Results: 236 PID episodes were identified among 230 patients. Comorbidities were present in 25.4%, predominantly prematurity (37.7%) and sickle cell disease (30.4%). The median age was 21.4-month-old. The most common diagnosis was bacteremia without a source (34%) and pneumonia (18%). Sepsis occurred in 17.4%. Clinical sequelae were present in 17.4%. Pneumonia and meningitis were associated to worse outcomes (p-value < 0.001). Mortality rate was 1.3%. Were isolated 279 microorganisms: 88% in blood; 6% in cerebrospinal fluid; 4% in pleural liquid; 2% in joint fluid. The most frequently isolated were Streptococcus pneumoniae (22.6%) and methicillin-susceptible Staphylococcus aureus (13.3%); 7.5% were MDR bacteria, of which 33% were community-associated.

Conclusion: PID is still an important cause of morbimortality. The incidence of MDR microorganisms is alarming, which alerts to the problem of wide use of antibiotics, especially broad spectrum.

Keywords: Bacteria; Fungi; Infectious Disease; Multi-Drug Resistance; Antimicrobial Susceptibility

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Citation

Citation: Adriana Costa., et al. “Invasive Disease in Pediatric Population - 10 Year Review". Acta Scientific Paediatrics 5.12 (2022): 10-18.

Copyright

Copyright: © 2022 Adriana Costa., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.