Giovanni Cacciaguerra¹*, Monica Palermo², Salvatore Michele Carnazzo¹, Giusi Maria.Caltabiano¹, Desireè Balconara¹, Maria Papale³, Giuseppe Fabio Parisi³ and Salvatore Leonardi³*

¹Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, Catania, Italy
²Clinica di Radiologia, EOC, Istituto Imaging della svizzera italiana, Lugano, Switzerland
³Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Catania, Italy

*Corresponding Author: Giovanni Cacciaguerra, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, Catania, Italy.

Received: August 24, 2022; Published: September 29, 2022

Abstract

B-type natriuretic peptide is a neurhormone isolated in ventricular cardiomyocytes and influences the balance of sodium and water by inducing natriuresis, diuresis and vasodilation, counteracting the renin-angiotensin-aldosterone system. The N-terminal pro-B natriuretic peptide (NT-proBNP), formed by 76 amino acids, has no bioactivity, the bioptive peptide is composed of 32 amino acids and derives from the cleavage of a precursor molecule. Type B natriuretic peptide is secreted mainly by the ventricles in response to the increase of left or right ventricular pressure and volume loads. Historically, B-type natriuretic peptide levels are related to one's severity and prognosis congestive and left ventricular heart failure. However, some studies have shown that NT-proBNP levels can also be elevated in diseases not purely cardiac such as acute infections, such as sepsis and other diseases in children. The association between serum levels of NTproBNP now measured in series and severity is the goal of numerous studies of the disease in children with pulmonary arterial hypertension (PAH). PAH is characterized by a progressive increase in pulmonary vascular resistance in the system pulmonary vascular precapillary, ultimately leading to right ventricular failure and death. Recent than publications, and one of the main ones we refer to for this communication, confirm that NT-proBNP has predictive value not only at diagnosis but also during the entire course of the disease.

References

1. Said F., et al. “Serial Measurements of N-Terminal Pro-B-Type Natriuretic Peptide Serum Level for Monitoring Pulmonary Arterial Hypertension in Children”. The Journal of Pediatrics 220 (2020): 139-145.
2. Pfister R and Schneider CA. “Natriuretic peptides BNP and NT-pro-BNP: established laboratory markers in clinical practice or just perspectives?” Clinica Chimica Acta 349 (2004): 25-38.
3. Nir A., et al. “NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies”. Pediatric Cardiology 1 (2009): 3-8.
4. Koch A., et al. “Decreasing ratio of plasma N-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide according to age”. Acta Paediatrics 95 (2006): 805-809.
5. Price JF., et al. “B-type natriuretic peptide predicts adverse cardiovascular events in pediatric outpatients with chronic left ventricular systolic dysfunction”. Circulation 114 (2006): 1063-1069.
6. Chin KM., et al. “Association of N-terminal pro brain natriuretic peptide and long-termoutcome in patients with pulmonary arterial hypertension”. Circulation 139 (2019): 2440-2450.
7. Bernus A., et al. “Brain natriuretic peptide levels in managing pediatric patients with pulmonary arterial hypertension”. Chest 135 (2009): 745-751.
8. Said F., et al. “Serial Measurements of N-Terminal Pro-B-Type Natriuretic Peptide Serum Level for Monitoring Pulmonary Arterial Hypertension in Children”. The Journal of Pediatrics 220 (2020): 139-145.

Citation

Citation: Giovanni Cacciaguerra., et al.. “Type B natriuretic peptide (NT-PROBNP), A Multipurpose Biomarker? A Possible Use in Pediatric Pneumology".Acta Scientific Paediatrics 5.10 (2022): 27-28.

Copyright

Copyright: © 2022 Giovanni Cacciaguerra.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.