Acta Scientific PAEDIATRICS (ISSN: 2581-883X)

Research Article Volume 5 Issue 9

Trend in Childhood Mortality After Pneumococcal Conjugate Vaccine (PCV-13) and Rotavirus Vaccines Introduction in the Nouna Health and Demographic Surveillance System, Burkina Faso

Mamadou Bountogo1,2*, Eric Nebié1,5,7, S Pascal Zabré1, Seraphin Simboro1, Ali Sié1,3,4, Nicolas Meda2 and Edouard Betsem6

1Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso, Africa

2Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso, Africa

3Heidelberg University, Heidelberg, Germany

4Proctor Foundation, University of California San Francisco, San Francisco, USA

5Swiss Tropical and Public Health Institute, Allschwil, Switzerland

6Faculty of Medicine and Biomedical Sciences, Yaounde, Cameroun

7University of Basel, Switzerland

*Corresponding Author: Mamadou Bountogo, Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso, Africa.

Received: August 04, 2022; Published: August 16, 2022

Abstract

Background: Pneumonia and diarrhea remain two leading causes of children under 5 years mortality. PCV-13 vaccine and rotavirus vaccine were introduced into the Burkina Faso EPI in 2013. Given the diversity of circulating serotypes and vaccine schedules, the WHO recommended an evaluation of their actual effectiveness after their introduction in different countries. This study, using an interrupted time series analysis, proposes to evaluate the effectiveness of PCV-13 and rotavirus vaccine on under 5 years mortality.

Methods: The study used interrupted time series designs with a pre-intervention period from 2009-2013 and a post-intervention period from 2014 to 2015.The monthly mortality rate ratio was the variable of interest. A generalized linear model was applied using log-transformed mortality rates as outcomes, with a Poisson distribution, adjusted.

Results: The infant mortality rate ratio was 0.84 (95% CI = 0.58-1.22, p = 0.37) 0.90 (95% CI = 0.70-1.15, p = 0.43), 0.84 (95% CI = 0.68;1.02, p = 0.09) on children aged 0-59 months, 0-11 months, 12-59 months, respectively. Although not statistically significant, the results in this study showed a 16% decrease in mortality in children aged 0-59 months

Conclusions: A positive effect of the newly introduced rotavirus and 13-valent pneumococcal conjugated vaccine was observed in the current study and needs to be consolidated in a bigger population size.

 

Keywords: Childhood Mortality; Trend; Nouna HDSS; PCV-13; Rotavirus Vaccines

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Citation

Citation: Mamadou Bountogo., et al. “Trend in Childhood Mortality After Pneumococcal Conjugate Vaccine (PCV-13) and Rotavirus Vaccines Introduction in the Nouna Health and Demographic Surveillance System, Burkina Faso". Acta Scientific Paediatrics 5.9 (2022): 15-21.

Copyright

Copyright: © 2022 Mamadou Bountogo., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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