Acta Scientific Paediatrics (ISSN: 2581-883X)

Editorial Volume 5 Issue 7

Vitamin D - A Fundamental Paradigm Shift in Pediatrics?

Abdul Halim Abdul Jalil*

KPJ Ampang Puteri Specialist Hospital, Selangor, Malaysia

*Corresponding Author: Abdul Halim Abdul Jalil, KPJ Ampang Puteri Specialist Hospital, Selangor, Malaysia.

Received: May 19, 2022; Published:

Abstract

Vitamin D deficiency/insufficiency in reality is a pandemic that is frequently undiagnosed and untreated [1-3] Research findings to date appear persuasive enough for clinicians to reconsider current clinical applicability of vitamin D supplementation.

The major source of vitamin D3 (cholecalciferol) in the body is an endogenous, naturally occurring phytochemically produced steroidal molecule. This is biologically inactive and requires enzymatic conversion to active metabolites. The plant source vitamin D2 (ergocalciferol) is less efficient and more toxic. and will not be referred to in this paper. Vitamin D3 is converted enzymatically in the liver to 25-hydroxyvitamin D (25[OH]D), the major circulating form of vitamin D, and then in the kidney to 1,25-dihydroxyvitamin D, the active form of vitamin D.

References

  1. Utiger RD. “The need for more vitamin D”. The New England Journal of Medicine 338 (1998): 828-829.
  2. Simon AE and Ahrens KA. Pediatrics (2020).
  3. Cashman KD., et al. “Vitamin D deficiency in Europe: pandemic?” The American Journal of Clinical Nutrition 103 (2016): 103344.
  4. Lansdowne AT and Provost SC. “Vitamin D3 enhances mood in healthy subjects during winter”. Psychopharmacology (Berl)4 (1998): 319-323.
  5. Christiansen C., et al. “Anticonvulsant action” of vitamin D in epileptic patients? A controlled pilot study”. The BMJ 913 (1974): 258-259.
  6. Alex Vasquez., et al. “The Clinical Importance of Vitamin D”. Alternative Therapy 10 (2004).
  7. Robert P Heaney. “Long-latency deficiency disease: insights from calcium and vitamin D”. The American Journal of Clinical Nutrition 5 (2003): 912-919.
  8. Wayse V., et al. “Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5y”. European Journal of Clinical Nutrition 4 (2004): 563-567.
  9. Adrian R Martineau., et al. “Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data”. BMJ 25 (2017): 356.
  10. Iacopo Chiodini., et al. “Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes”. Systematic review article”. Frontiers in Public Health (2021).
  11. Ashu Rastogi., et al. “Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)”. Postgraduate Medical Journal1156 (2020).

Citation

Citation: Abdul Halim Abdul Jalil. “Vitamin D - A Fundamental Paradigm Shift in Pediatrics?”. Acta Scientific Paediatrics 5.7 (2022): 00-00.

Copyright

Copyright: © 2022 Abdul Halim Abdul Jalil. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor1.197

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