Acta Scientific Paediatrics (ISSN: 2581-883X)

Research Article Volume 5 Issue 2

Serum Albumin Level in Critically Ill Pediatric Patients

Gurkan Atay* and Seher Erdoğan

Department of Pediatric Critical Care, Health Science University, Umraniye Research and Training Hospital, Istanbul,Turkey

*Corresponding Author: Gurkan Atay, Department of Pediatric Critical Care, Health Science University, Umraniye Research and Training Hospital, Istanbul,Turkey.

Received: May 03, 2021; Published: January 13, 2022

Abstract

Objective: Hypoalbuminemia is a frequent condition among patients admitted to pediatric intensive care unit (PICU). The aim of the present study was to determine the prevalence of hypoalbuminemia among critically ill pediatric patients, and to assess its relationship with prognosis.

Materials and Methods: Age, sex, admission diagnosis, Pediatric Risk of Mortality (PRISM) scores, serum total protein and albumin levels, mechanical ventilation (mv) need, number of days on mv, number of PICU days, number of hospital days, and prognosis were recorded among patients admitted to PICU between May 2017 and May 2018. The patients were grouped into two groups on the basis of their serum albumin level; those with hypoalbuminemia were assigned to Group 1 and those without to Group 2.

Results: The study enrolled a total of 126 pediatric patients of whom 64 (50.8%) were female and 62 (49.2%) were male. The mean age of the study population was 64.66 ± 71.28 months. One hundred and five (83.3%) patients survived and 21 (16.7%) died. Forty-six (36.5%) patients had hypoalbuminemia. In patients assigned to Group 1 the need for mechanical ventilation was significantly greater (p:0.007), but there was no significant difference between the number of mv days (p:0.64). Group 1 had a significantly greater PRISM score, a significantly longer hospital stay, and a significantly greater mortality rate (p:0.000, p:0.013, and p:0.000, respectively). No significant difference was seen for the number of PICU days. A prognosis analysis revealed that the survivor group had a higher mean age, less mv need, shorter hospitalization and mv time, and lower serum total protein and albumin levels.

Conclusion: We suggest that serum albumin level is an important prognostic marker as it is a simple, specific, and low-cost parameter that is routinely used in most PICUs.

Keywords: Inflammatory Bowel Disease; Crohn’s Disease; Ulcerative Colitis; Faecal Calprotectin; Endoscopy; Diagnosis; Biomarker

References

  1. Vincent JL. “Relevance of albumin in modern critical care medicine”. Best Practice and Research: Clinical Anaesthesiology 23 (2009): 183-191.
  2. Nicholson JP., et al. “The role of albumin in critical illness”. British Journal of Anaesthesia 85 (2000): 599-610.
  3. Vincent JL., et al. “Albumin administration in the acutely ill; what is new and where next?” Critical Care 18 (2014): 231-241.
  4. Rodoman GV., et al. “Serum albumin in systemic inflammatory reaction syndrome”. Anesteziologiia Reanimatologiia 2 (2006)”62-64.
  5. Kumar S., et al. “Hypoalbuminemia aş a marker of adverse outcome in children admitted to pediatric intensive care unit”. Indian Journal of Child Health 1 (2018).
  6. Leite HP., et al. “Serum albumin is an independent predictor of clinical outcomes in critically ill children”. Pediatric Critical Care Medicine 2 (2016): e50-70.
  7. Horowitz IN and Tai K. “Hypoalbuminemia in Critically ill children”. Archives of Pediatrics and Adolescent Medicine 161 (2007): 1048-1052.
  8. Kittisakmontri K., et al. “Hypoalbuminaemia at admission predicts the poor outcomes in critically ill children”. Anaesthesiology Intensive Therapy 48 (2016): 158-161.
  9. Durward A., et al. “Hypoalbuminemia in critically ill children: incidence, prognosis and influence on the anion gap”. Archives of Disease in Childhood 88 (2003): 419-422.
  10. Tiwari LK., et al. “Hypoalbuminemia in critically sick children”. Indian Journal of Critical Care Medicine 18 (2014): 565-569.
  11. Fanali G., et al. “Human serum albumin: From bench to bedside”. Molecular Aspects of Medicine 33 (2012): 209-290.
  12. Martin GS., et al. “Albumin and furasemide therapy in hypoproteinemic patients with acute lung injury”. Critical Care Medicine 30 (2002): 2175-2182.
  13. American Thoracic Society. “Evidence-based colloid use in the critically ill: American Thoracic Society Consensus Statement”. American Journal of Respiratory and Critical Care Medicine 170 (2002): 1247-1259.
  14. Finfer S., et al. SAFE Study Investigators. “A comparison of albumin and saline for fluid resuscitation in the intensive care unit”. The New England Journal of Medicine 350 (2004): 2247-2256.
  15. Charpenter J and Mira JP. EARSS study group: “Effeciency and tolerance of hyperoncotic albumin administration in septic shock patients: the EARSS study”. Intensive Care Medicine 37 (2011): S115-0438.
  16. Caironi P., et al. “Albumin replacement in patients with severe sepsis or septic shock”. The New England Journal of Medicine 370 (2014): 1412-1421.
  17. Vincent JL., et al. “Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials”. Annals of Surgery 237 (2003): 319-334.

Citation

Citation: Gurkan Atay and Seher Erdoğan. “Serum Albumin Level in Critically Ill Pediatric Patients". Acta Scientific Paediatrics 5.2 (2022): 03-07.

Copyright

Copyright: © 2022 Gurkan Atay and Seher Erdoğan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor1.197

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US