Sumant Patil¹*, Gayatri Bhide², Rajan Joshi³ and Pratibha Phasale⁴

¹Consultant Paediatric Intensivist, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India
²Consultant Paediatrician, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India
³Consultant Paediatrician, Head of the Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India
⁴DNB Resident, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India

*Corresponding Author: Sumant Patil, Consultant Paediatric Intensivist, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India.

Received: September 24, 2021; Published: November 17, 2021

Abstract

Background: Limited data have emerged describing the presentation and clinical characteristics of the paediatric patients with SARS CoV-2 infection. Majority of this data was from the initial part of the pandemic and mainly from China, some from Europe and USA, although none significant from the Indian sub-continent.

Aim : To describe clinical profile of paediatric SARS CoV-2 infection from a tertiary centre in western India covering the first active duration of COVID -19 pandemic.

Material and Methods: Retrospective observational cohort study over 6 months from 1^st April 2020 to 30^th September 2020.

Participants

• Children aged 0 to <18 years, admitted in hospital with COVID-19 infection.
• Positive for SARS-CoV-2 infection using RT-PCR or rapid antigen test from oropharyngeal and nasopharyngeal swabs.

Results: 148 children hospitalised with confirmed SARS CoV-2 infection were included with median age of 8.07 years (IQR 3.07 to 13.11 years) and sex ratio of 1.42 males per female. Of these 57(38.5%) were asymptomatic and 91(61.5%) were symptomatic. Fever was the commonest presenting feature in 65(43.9%), followed by cough 34(23%) and runny nose in 25(16.9%). Pediatric intensive care unit admission was needed in 9(6.1%) patients and there was one neonatal death.

Conclusion: This study confirms that the pattern of disease presentation is mild in pediatric population with a high number of asymptomatic patients and exceedingly rare mortality due to SARS-CoV-2 infection.

Keywords: COVID-19; SARS-CoV-2; RT-PCR; Rapid Antigen Test; Clinical Profile in Children

References

1. Wang C., et al. “A novel coronavirus outbreak of global health concern”. Lancet 10223 (2020): 470-473.
2. Adhikari SP., et al. “Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review”. Infectious Diseases of Poverty 1 (2020): 29.
3. Shekerdemian LS., et al. “Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units”. JAMA Pediatrics9 (2020): 868-873.
4. Zimmermann P and Curtis N. “Coronavirus infections in children including COVID-19: An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children”. Pediatric Infectious Disease Journal 39 (2020): 355.
5. A Hoang., et al. “COVID-19 in 7780 pediatric patients: a systematic review”. EClinicalMedicine 24 (2020).
6. Bailey LCRH., et al. “Assessment of 135794 pediatric patients tested for Severe Acute Respiratory Syndrome Coronavirus 2 across the united states”. JAMA Pediatrics2 (2020): e205052.
7. Gotzinger Florian., et al. “COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study”. The Lancet Child and Adolescent Health9 (2020): 653-661.
8. Song W., et al. “Clinical features of pediatric patients with coronavirus disease (COVID-19)”. Journal of Clinical Virology (2020): 104377.
9. Sisk B., et al. “National Trends of Cases of COVID-19 in Children Based on US State Health Department Data”. Pediatrics 6 (2020): e2020027425.
10. Ding Y., et al. “Clinical characteristic of children with COVID-19; a meta-analysis”. Frontiers in Paediatrics 8 (2020): 431.
11. Badal S., et al. “Prevalence, clinical characteristics and outcome of pediatric COVID-19 : a systematic review and meta-analysis”. Journal of Clinical Virology 135 (2020): 104715.
12. https://covid19.who.int WHO Coronavirus Disease (COVID-19) dashboard (2021).
13. https://www.covid19maharashtragov.in/mh-covid/dashboard COVID-19 dashboard by Government of Maharashtra, India (2021).
14. Hasell J., et al. “A cross-country database of COVID-19 testing”. Scientific Data 7 (2020): 345.
15. Leidman E., et al. “COVID-19 trends among persons aged 0-14 years - United states, March 1-December 12,2020”. Morbidity and Mortality Weekly Report 70 (2021): 88-94.
16. Swann OV., et al. “Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study”. BMJ 370 (2020): m3249.
17. Dong Y., et al. “Epidemiology of COVID-19 Among Children in China”. Pediatrics 145 (2020): e20200702.
18. Lu X., et al. “SARS-CoV-2 infection in children”. The New England Journal of Medicine 382 (2020): 1663-1665.
19. N Kumar., et al. “Descriptive epidemiology of SARS-COV-2 infection in Karnataka state South India: Transmission dynamics of symptomatic vs. asymptomatic infections”. EClinicalMedicine-The Lancet100717 (2021).
20. Soni SL., et al. “Demographic and clinical profile of patients with COVID-19 at a tertiary care hospital in north India”. Indian Journal of Medical Research (2020).
21. Bhandari ., et al. “Clinical Profile of Covid-19 Infected Patients Admitted in a Tertiary Care Hospital in North India”. Journal of the Association of Physicians of India 5 (2020): 13-17.
22. DeBiasi RL., et al. “Severe COVID-19 in children and young adults in the Washington, DC metropolitan region”. Journal of Pediatrics 223 (2020): 199-203.
23. Liu WJ., et al. “T-cell immunity of SARSCoV: Implications for vaccine development against MERS-CoV. Antiviral Research 137 (2017): 82-92.
24. Henry BM., et al. “Laboratory abnormalities in children with novel coronavirus disease 2019”. Clinical Chemistry and Laboratory Medicine 58 (2020): 1135-1138.
25. BK Tsankov., et al. “Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis”. International Journal of Infectious Diseases 103 (2021): 246-256.

Citation

Citation: Sumant Patil., et al. “ Clinical Profile of Children with SARS-CoV-2 Infection from a Tertiary Centre in Western India During the First Wave of COVID-19 Pandemic”. Acta Scientific Paediatrics 4.12 (2021): 18-25.

Copyright

Copyright: © 2021 Sumant Patil., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.