Acta Scientific Paediatrics (ISSN: 2581-883X)

Case Report Volume 4 Issue 10

Giant Cell Hepatitis with Autoimmune Hemolytic Anemia- Case Report

Barreto Julie1*, Ribeiro Hildenia1, Coelho Fabiana1, Lustosa Amalia1 and Moraes Carlos2

1Pediatric Gastroenterology Department, Hospital Infantil Albert Sabin, Brazil
2Pediatric Hematology Department, Hospital Infantil Albert Sabin, Brazil

*Corresponding Author: Barreto Julie, Pediatric Gastroenterology Department, Hospital Infantil Albert Sabin, Fortaleza, Ceara, Brazil.

Received: April 21, 2021; Published: September 06, 2021

Abstract

  Giant cells hepatitis associated with autoimmune hemolytic anemia is a rare pathology. An autoimmune disease characterized as a serious liver disease associated with hemolytic anemia. It is still little described in the literature, it has a restrict number of case reports and its pathophysiology is unclear. This study presents a report of two cases of patients diagnosed with giant cells hepatitis associated with autoimmune hemolytic anemia in their first year of age. They show different evolutions of the same pathology displaying the possibilities of manifestation regarding the hepatic and pathological involvement. The patients had severe evolutions, without any response to the first therapeutical measures, had a surprising improvement with the use of anti-b-cell monoclonal antibody treatment, rituximab. The cases of liver disease associated with autoimmune hemolytic must undergo a liver biopsy as early as possible in order to reach a definitive diagnosis. The use of rituximab associated with immunoglobulin infusion has been shown to be an effective treatment and may be considered a first-line therapy, along with a short period of corticotherapy.

Keywords: Giant Cell Hepatitis; Anemia; Rituximab; Rare Disease

References

  1. Paganelli M., et al. “Anti-CD20 Treatment of Giant Cell Hepatitis with Autoimmune Hemolytic Anemia”. Pediatrics 134 (2014): 1206-1210.
  2. Nastasio S., et al. “Should Giant Cell Hepatitis with Autoimmune Hemolytic Anemia be considered a Pediatric autoimmune liver disease?” Journal of Pediatric gastroenterology and Nutrition5 (2018): e137.
  3. Bakula A., et al. “Giant Cell Hepatitis with Autoimmune Hemolytic Anemia in Children: Proposal for Therapeutic Approach”. Hepatology and Nutrition 5 (2014): 669-673.
  4. Bouguila J., et al. “Giant Cell Hepatitis with Autoimmune Hemolytic Anemia in a nine month old infant”. World Journal of Hepatology 5 (2013): 226-229.
  5. Annibali R., et al. “Giant Cell Hepatitis and Autoimmune Hemolytic Anemia: A 19 months follow-up”. Digestive and Liver Disease 45 (2013): e306.
  6. Whittington PF., et al. “Humoral Immune Mechanism of Liver Injury in Giant Cell Hepatitis with Autoimmune Hemolytic Anemia”. Hepatology and Nutrition1 (2014): 74-80.
  7. Marsalli G., et al. “Efficacy of intravenous immunoglobulin therapy in Giant Cell Hepatitis with Autoimmune Hemolytic Anemia: a multicenter study”. Clinics and Research in Hepatology and Gastroenterology1 (2015): 83-89.
  8. Isa HM., et al. “Giant Cell Hepatitis and Coombs positive Autoimmune Hemolytic Anemia: a case report and literature review”. Journal of the Bahrain Medical Society1 (2014): 42-46.
  9. Gomez J and Valverde K. “Anemia Hemolítica Autoimune em um nino com hepatitis de células gigantes”. Acta Medica Constarricense4 (2012): 269-271.
  10. Kim Y., et al. “Successful Treatment of a Korean Infant whith Giant Cell Hepatitis with Aoutoimmune Hemolytic Anemia using Rituximab”. Pediatric Gastroenterology Hepatologys e Nutrition2 (2020): 180-187.
  11. Marsalli G., et al. “Efficacy of intravenous immunoglobulin therapy in Giant Cell Hepatitis with Autoimmune Hemolytic Anemia: a multicenter study”. Clinics and Research in Hepatology and Gastroenterology1 (2015): 83-89.
  12. Matarazzo L., et al. “B-cell depletion induces prolonged remission in patients with Giant Hepatitis and Autoimmune hemolytic Anemia”. Clinics and research in Hepatology and Gastroenterology1 (2020): 66-72.
  13. Vergani M., et al. “Diagnosis and management of pediatric autoimmune liver disease: ESPGHAN Hepatology Committee Statement”. Journal Pediatric Gastroenterology and Nutrition 66 (2018): 345-360.

Citation

Citation: Barreto Julie., et al. “ Giant Cell Hepatitis with Autoimmune Hemolytic Anemia- Case Report”. Acta Scientific Paediatrics 4.10 (2021): 09-12.

Copyright

Copyright: © 2021 Barreto Julie., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor1.197

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US