Acta Scientific Paediatrics (ISSN: 2581-883X)

Case Report Volume 4 Issue 10

Giant Cell Hepatitis with Autoimmune Hemolytic Anemia- Case Report

Barreto Julie1*, Ribeiro Hildenia1, Coelho Fabiana1, Lustosa Amalia1 and Moraes Carlos2

1Pediatric Gastroenterology Department, Hospital Infantil Albert Sabin, Brazil
2Pediatric Hematology Department, Hospital Infantil Albert Sabin, Brazil

*Corresponding Author: Barreto Julie, Pediatric Gastroenterology Department, Hospital Infantil Albert Sabin, Fortaleza, Ceara, Brazil.

Received: April 21, 2021; Published: September 06, 2021

Abstract

  Giant cells hepatitis associated with autoimmune hemolytic anemia is a rare pathology. An autoimmune disease characterized as a serious liver disease associated with hemolytic anemia. It is still little described in the literature, it has a restrict number of case reports and its pathophysiology is unclear. This study presents a report of two cases of patients diagnosed with giant cells hepatitis associated with autoimmune hemolytic anemia in their first year of age. They show different evolutions of the same pathology displaying the possibilities of manifestation regarding the hepatic and pathological involvement. The patients had severe evolutions, without any response to the first therapeutical measures, had a surprising improvement with the use of anti-b-cell monoclonal antibody treatment, rituximab. The cases of liver disease associated with autoimmune hemolytic must undergo a liver biopsy as early as possible in order to reach a definitive diagnosis. The use of rituximab associated with immunoglobulin infusion has been shown to be an effective treatment and may be considered a first-line therapy, along with a short period of corticotherapy.

Keywords: Giant Cell Hepatitis; Anemia; Rituximab; Rare Disease

References

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Citation

Citation: Barreto Julie., et al. “ Giant Cell Hepatitis with Autoimmune Hemolytic Anemia- Case Report”. Acta Scientific Paediatrics 4.10 (2021): 09-12.

Copyright

Copyright: © 2021 Barreto Julie., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Impact Factor1.197

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