Enas Elnagar¹*, Amal Abdel-Hameed², Hanan Omar³, Mohamed El-Kalioby⁴ and Abdelmoneim Khashana⁵

¹Lecturer of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt
²Faculty of Medicine, Suez Canal University, Egypt
³Associate Professor of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt
⁴Professor of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt
⁵Associate Professor, Faculty of Medicine, Suez Canal University, Egypt

*Corresponding Author: Enas Elnagar, Lecturer of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt.

Received: May 24, 2021; Published: July 14, 2021

Abstract

Neonatal sepsis represents an important cause of morbidity and mortality especially in low-resource settings. Early diagnosis and prompt treatment of neonatal sepsis improves outcome. The aim of this study is determine the role of platelet indices and serum uric acid level in the early diagnosis of neonatal sepsis and early detection of neonatal sepsis with easily accessible, inexpensive, and widely used laboratory tests. Retrospective case-control study the target population of this study consisted of 120 neonates who were divided into two groups, cases: 60 neonates who had clinical picture of sepsis with or without positive blood culture, and controls 60 healthy non-septic neonates of the same age and maturity. Platelet parameters followed in complete blood picture (CBC), and serum uric acid of all neonates. Our results showed decrease platelet parameters and serum uric acid in cases of neonatal sepsis so we can use these tools as predictors of neonatal sepsis. There was significant difference of platelet parameters and serum uric acid between cases and controls, significantly lower in neonates with sepsis compared to healthy controls. Decreased platelet parameters including (platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and platelet crit (PCT) values suggest possibility of sepsis and should alert clinicians to the possibility of sepsis and to initiate or change antibiotic treatment. There was statistically significant difference between cases and controls regarding to uric acid.

Keywords: Neonatal Sepsis; Platelet Indices; Serum Uric Acid

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Citation

Citation: Enas Elnagar., et al. “ Decreased Platelet Parameters and Serum Uric Acid Levels Suggest Possibility of Acute Phase Reaction of Neonatal Sepsis”. Acta Scientific Paediatrics 4.8 (2021): 35-40.

Copyright

Copyright: © 2021 Enas Elnagar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.