Acta Scientific Paediatrics (ISSN: 2581-883X)

Research Article Volume 4 Issue 7

Follow Up the Children with Ocular Lesion Induced by Two Common Intrauterine Infections (Cytomegalovirus, Toxoplasmosis): A Cohort Study in Tehran, Iran

Mohammad Vafaee-Shahi1, Samileh Noorbakhsh2*, Leila Tahernia3 and Sarvenaz Ashouri4

1Assistant Professor of Pediatric Neurology, Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran, Iran
2Professor of Pediatric Infectious Disease, Pediatric Infectious Diseases Department and Research center, Iran University of Medical Sciences, Tehran, Iran
3Fellowship of Pediatric ICU, Tehran University of Medical Sciences, Tehran, Iran
44ENT and Head and Neck Research Center and Department, Iran University of Medical Sciences, Tehran, Iran

*Corresponding Author: Samileh Noorbakhsh, Professor of Pediatric Infectious Disease, Pediatric Infectious Diseases Department and Research center, Iran University of Medical Sciences, Tehran, Iran.

Received: April 24, 2021; Published: June 23, 2021

Abstract

Background: Intrauterine infections lead to involvement of various organs in fetus, including the eye. The aim of this study was to determine the frequency and clinical response of ocular lesions to specific drugs in infants with congenital Toxoplasma and cytomegalovirus infections.

Methods: This historical cohort study was performed in the pediatric and ophthalmology department of Hazrat Rasool Akram Hospital in Tehran from October 2011 to November 2017. Patients included 78 infants with intrauterine infection (proven) and ocular involvement (cataracts, glaucoma, and retinitis). Infants who did not undergo additional and diagnostic tests, eye examinations, follow-up and did not receive effective treatment were excluded from the study. Three patients expired during the study. Finally, 37 patients (including 25 patients with cytomegalovirus and 12 patients with toxoplasma) were included to assess and the clinical response to ocular lesions was evaluated for one year.

Results: Of 12 cases with toxoplasmosis, 5 patients received complete treatment and 4 patients had appropriate clinical responses. Of 25 patients with CMV, 18 patients received complete treatment and 9 patients had appropriate clinical responses.

Conclusion: Successful treatment will be obtained in near 80% of ocular toxoplasmosis, so anti toxoplasma treatment is recommended in all confirmed cases. About 50% of CMV infected cases (with hearing loss, ocular involvement) might respond well to antiviral therapy, We recommend anti CMV treatment in any age (< 2 years old) but it is not indicated in CMV infected cases with severe brain involvement.

Keywords: Cytomegalovirus; Ocular Disorders; T. gondii; Intrauterine Infections; Infants

References

  1. Kenneson A and Cannon MJ. “Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection”. Reviews in Medical Virology4 (2007): 253-276.
  2. Dollard SC., et al. “New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection”. Reviews in Medical Virology5 (2007): 355-363.
  3. Yamamoto AY., et al. “Congenital cytomegalovirus infection as a cause of sensorineural hearing loss in a highly immune population”. The Pediatric Infectious Disease Journal12 (2011): 1043-1046.
  4. James SH and Kimberlin DW. “Advances in the prevention and treatment of congenital cytomegalovirus infection”. Current Opinion in Pediatrics1 (2016): 81-85.
  5. Barbi M., et al. “A wider role for congenital cytomegalovirus infection in sensorineural hearing loss”. The Pediatric Infectious Disease Journal1 (2003): 39-42.
  6. Thalib L., et al. “Prediction of congenital toxoplasmosis by polymerase chain reaction analysis of amniotic fluid”. BJOG: An International Journal of Obstetrics and Gynaecology5 (2005): 567-574.
  7. Naing ZW., et al. “Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention”. The Australian and New Zealand Journal of Obstetrics and Gynaecology1 (2016): 9-18.
  8. Rossi P. “Diagnostic kits in parasitology: which controls?” Parasitologia 1-2 (2004): 145-149.
  9. Sotoodeh A., et al. “Cytomegalovirus immunity in South of Iran”. American Journal of Infectious Diseases 6 (2010): 8-12.
  10. Bagheri L., et al. “Seroprevalence of cytomegalovirus infection among pregnant women in Eastern Iran”. The Brazilian Journal of Infectious Diseases 16 (2012): 402-403.
  11. Rhead WJ and Irons M. “The call from the newborn screening laboratory: frustration in the afternoon”. Pediatric Clinics of North America 3 (2004): 803-818.
  12. Ghaemian M., et al. “Determination of antibodies (IgG, IgM) against toxoplasma gondii in patients with cancer”. Iranian Journal of Parasitology 2 (2007): 1-6.
  13. Foroutan-Rad M., et al. “Seroprevalence of Toxoplasma gondii in the Iranian pregnant women: A systematic review and meta-analysis”. Acta Tropica 158 (2016): 160-169.

Citation

Citation: Samileh Noorbakhsh., et al. “Follow Up the Children with Ocular Lesion Induced by Two Common Intrauterine Infections (Cytomegalovirus, Toxoplasmosis): A Cohort Study in Tehran, Iran”. Acta Scientific Paediatrics 4.7 (2021): 36-40.

Copyright

Copyright: © 2021 Samileh Noorbakhsh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor1.197

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2022.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US