Acta Scientific Paediatrics (ISSN: 2581-883X)

Review ArticleVolume 4 Issue 5

Recent Approaches in the Management of Difficult to Treat Asthma in Pediatric Population - A Brief Review

Edwin Dias1,2* and Shwetha N3

1Professor and Head, Department of Pediatrics, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, Karnataka State, India
2Adjunct Research Professor, College of Allied Health Sciences, Srinivas University, Mangalore, India
3Final Year Pharm D., Srinivas College of Pharmacy, Valachil, Mangalore, Karnataka State, India

*Corresponding Author: Edwin Dias, Professor and Head, Department of Pediatrics, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, Karnataka State, India.

Received: April 26, 2021; Published: May 16, 2021

Citation: Edwin Dias and Shwetha N. “Recent Approaches in the Management of Difficult to Treat Asthma in Pediatric Population - A Brief Review”. Acta Scientific Paediatrics 4.6 (2021): 24-35.


Introduction: Pediatric patients with difficult-to-treat asthma experience a heavy burden of exacerbations, symptoms, therapeutic failure, adverse drug reactions, and increased health care costs. Frequent cough, dyspnoea, chest tightness, and wheeze interfere with normal daily activities, sleeping, overall quality of life, and education of children. Difficult-to-treat asthma affects a small group of children with asthma but represents a challenging mix of misdiagnosis or incorrect diagnosis, multiple co-morbidities, severe airway pathophysiology, inadequate self-management, and treatment complications. Thus management of such cases requires beyond pharmacotherapy of asthma because patient-related and disease-related domains need to be considered first. Therefore, prevention of asthma exacerbations is an essential goal in difficult-to-treat asthma therapy and requires more focused individualized treatment that involves the elimination of risk factors, treatment of co-morbidities, treatment with anti-asthmatics, and improving medication adherence.

Methodology: A brief review of all the relevant standard articles was conducted.

Results: The study involved a brief review on assessment of risk factors in the pediatric population with difficult-to-treat asthma and pharmacological management i.e. optimal use of long-acting muscarinic antagonist (tiotropium), and biological monoclonal antibody treatment (Omalizumab, Mepolizumab, Dupilumab, and Benralizumab) which were found to be safe and effective in the pediatric population.

Conclusion: Management of difficult-to-treat asthma in the pediatric population requires the elimination of modifiable risk factors, treatment of co-morbidities, and treatment of exacerbations with newer agents which were found to be effective in reducing hospitalizations and frequent Emergency Department visits. Thus individualized treatment must be preferred in these patients.

Keywords: Difficult-to-Treat Asthma; Pediatrics; Risk Factors; Recent Approaches; Management


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Copyright: © 2021 Edwin Dias and Shwetha N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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