Acta Scientific Paediatrics (ISSN: 2581-883X)

Research Article Volume 3 Issue 11

Comparative Analysis of Candida albicans Versus Candida Non-albicans Infection among Pediatric Patients at King Abdulaziz University Hospital

Khouloud Abdulrhman Al-Sofyani1*, Mohammed Shahab Uddin2, Huda Saeed Alghamdi3 and Dalia El-Hossary4,5

1Department of Pediatric, Pediatric Intensive Critical Care Unit, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
2Department of Pediatric, Pediatric Intensive Critical Care Unit, National Guard Health Affairs, Dammam, Kingdom of Saudi Arabia
3Consultant Medical Microbiology, Clinical and Molecular Microbiological Laboratory, Faculty of Medicine and Medical Microbiology, King Abdulaziz Hospital, Jeddah, Kingdom of Saudi Arabia
4Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt
5Clinical and Molecular Microbiological Laboratory, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

*Corresponding Author: Khouloud Abdulrhman Al-Sofyani, Department of Pediatric, Pediatric Intensive Critical Care Unit, King Abdulaziz University, Jeddah, Saudi Arabia.

Received: September 25, 2020; Published: October 28, 2020

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Abstract

Background : Candidemia is one of the major causes of morbidity and mortality among critically ill pediatric patients. This study aimed to determine the prevalence of Candida infection, different strains, associated risk factors, and outcomes in critically ill patients with candidemia.

Method: Critically ill pediatric patients with invasive candidiasis were included in this retrospective study. Patients were 14 years or younger, admitted to King Abdulaziz University Hospital from March 2018 to February 2020.

Results: Out of 61 pediatric patients cases with candidemia, 23 (37.7%) patients were diagnosed with C. albicans and 38 (62.3%) with non-albicans. Species present in non-albicans Candida group included Candida parapsilosis 15 (24.6%), Candida topicalis 12 (19.7%) and Candida glabrata 4 (6.6%). Majority Candida strains were sensitive to antifungals. The main admitting diagnosis was sepsis 21 (34.4%) and the main isolation site of Candida species was blood. The main risk factors and predictors of candidemia were age younger than 5 months, presence of a central venous catheter, urinary catheter, using TPN, and blood products transfusion. Finally, the number of mortalities and length of ICU stay was higher among C. albicans patients, whereas the duration of hospitalization, broad-spectrum antimicrobial and antifungal treatment, were higher among C. non-albicans infected patients.

Conclusion: Although C. albicans infection cases are still dominant, however, the number of cases due to C. non-albicans infection is high. The study also highlighted some of the indicators that may help in early prophylactic intervention, which in turn can help improve the poor clinical prognostic outcome in Saudi Arabia.

Keywords: Candidemia; Candida albicans; Candida non-albicans; Risk Factors; Outcome

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Citation

Citation: Khouloud Abdulrhman Al-Sofyani., et al. "Comparative Analysis of Candida albicans Versus Candida Non-albicans Infection among Pediatric Patients at King Abdulaziz University Hospital". Acta Scientific Paediatrics 3.11 (2020): 37-47.




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