Abstract

  We carried out a single centre, prospective, non-interventional observational study of consecutive neonates admitted in neonatal intensive care unit. We evaluated 150 neonates with seizures admitted to NICU in our centre from October 2015 to September 2017 over duration of two years. All subjects were evaluated on clinical basis; physical examination was done to look for vitals, blood pressure, and cyanosis. Historical evaluation included demographic details and antenatal history to know the risk factors associated with occurrence of seizures in newborn. Special emphasis was given on risk factors like maternal age, gestation, birth order, prolonged or difficult labour, birth asphyxia, sepsis, maternal diabetes mellitus, and drug consumption during pregnancy. Appropriate laboratory investigations were sent including haemogram, blood sugar, serum calcium, serum magnesium, other blood biochemistries, blood culture and neuroimaging work up was done, if required. All data was then entered into a prestructured proforma/case history forms and statistical analysis was done. Our study revealed that the most common etiology of seizures in our series was birth asphyxia. Metabolic disturbances were 2nd most common etiology in which hypocalcemia was the most common type. Males outnumbered females, and seizures occurred most commonly in full term neonates as compared to preterm. The most common type of seizure was the subtle type followed by tonic and then clonic and myoclonic. Birth asphyxia which was most common occurred on day of life 1. Metabolic seizures were most commonly occurred on day of life 4 to 7. Birth asphyxia was the most common etiology in both term and preterm babies. Phenobarbitone was the most common antiepileptic drug used in our study. All cases were also additionally managed for their underlying condition according to standard N.I.C.U protocols with special emphasis on hemodynamic stability.

Keywords: Neonates; Seziures; Asphyxia; Metabolic; Critical Care; Epilepsy

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Citation

Citation: Mitesh Chawda., et al. “The Clinicoetiological Profile of Neonatal Seizure at Level-II NICU in a Territory Care Hospital, Chhattisgarh". Acta Scientific Paediatrics 3.11 (2020): 20-29.

Copyright

Copyright: © 2020 Mitesh Chawda., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.