Abstract

  Globally one out of every ten babies is born premature (before 37 completed weeks of pregnancy). Infact, it is an universal problem. As problems with prematurity are multifocal from functional immaturity of the organs to vulnerable low temperature as well as exposure to notorious free radical injury. Free radicals generation is an unavoidable consequence of life. During the perinatal period, overproduction of free radicals and insufficiency of antioxidant leading to oxidative stress, a deleterious process. This imbalance with predisposing conditions as hypoxia, ischemia, hypoxia-ischemia-reperfusion injury or inflammation and high levels of non-protein bound iron have been thought to be factor of the so-called “free radical related diseases of prematurity” including Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD), Necrotizing Enterocolitis (NEC), Intraventricular Hemorrahge (IVH), Renal damage, Oxidative hemolysis. The effects of antioxidant therapy remains controversial. So, very much careful individualized control of oxygenation, blood flow perfusion with adequate intake of nutrients that have antioxidant function and rational steps to management of infection seems to be the best attempt to prevent free radical aggression of prematurity. In this review, we provide an update focused on the factors influencing these diseases.

Keywords: Prematurity; Free Radicals; Oxidative Stress

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Citation

Citation: Mir Mohammad Yusuf.,et al. “Free Radical Related Diseases of Prematurity - A Morbid Concern of Neonatal Life". Acta Scientific Paediatrics 3.10 (2020): 28-34.

Copyright

Copyright: © 2020 Mir Mohammad Yusuf.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.