Acta Scientific Paediatrics (ISSN: 2581-883X)

Review Article Volume 3 Issue 10

Free Radical Related Diseases of Prematurity - A Morbid Concern of Neonatal Life

Mir Mohammad Yusuf1*, Manzoor Hussain2 and MAK Azad Chowdury3

1Assistant Professor, Critical Care Department, Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Bangladesh
2Professor and Head, Department of Pediatric Medicine and Cardiology, Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Bangladesh
3Professor and Head, Department of Neonatology, Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Bangladesh

*Corresponding Author: Mir Mohammad Yusuf, Assistant Professor, Critical Care Department, Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Bangladesh.

Received: July 13, 2020; Published: September 16, 2020



  Globally one out of every ten babies is born premature (before 37 completed weeks of pregnancy). Infact, it is an universal problem. As problems with prematurity are multifocal from functional immaturity of the organs to vulnerable low temperature as well as exposure to notorious free radical injury. Free radicals generation is an unavoidable consequence of life. During the perinatal period, overproduction of free radicals and insufficiency of antioxidant leading to oxidative stress, a deleterious process. This imbalance with predisposing conditions as hypoxia, ischemia, hypoxia-ischemia-reperfusion injury or inflammation and high levels of non-protein bound iron have been thought to be factor of the so-called “free radical related diseases of prematurity” including Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD), Necrotizing Enterocolitis (NEC), Intraventricular Hemorrahge (IVH), Renal damage, Oxidative hemolysis. The effects of antioxidant therapy remains controversial. So, very much careful individualized control of oxygenation, blood flow perfusion with adequate intake of nutrients that have antioxidant function and rational steps to management of infection seems to be the best attempt to prevent free radical aggression of prematurity. In this review, we provide an update focused on the factors influencing these diseases.

Keywords: Prematurity; Free Radicals; Oxidative Stress



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Citation: Mir Mohammad Yusuf.,et al. “Free Radical Related Diseases of Prematurity - A Morbid Concern of Neonatal Life". Acta Scientific Paediatrics 3.10 (2020): 28-34.


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