Acta Scientific Paediatrics (ISSN: 2581-883X)

Case Report Volume 3 Issue 7

Risperidone Overdose with Acute Dystonia in Children - A Case Report

Rashmi Patil, Megha P, Chikkanarasa Reddy PS*, Kalpana, Niharika Shetty and Sarala Sabapathy

Department of Paediatrics, Bangalore Medical College and Research Institute, Bangalore, India

*Corresponding Author: Chikkanarasa Reddy PS, Assistant Professor in Paediatrics, Bangalore Medical College and Research Institute, Bangalore, India.

Received: June 01, 2020; Published: June 23, 2020

×

Abstract

Prescription of atypical antipsychotics has been on increasing trend in adults and adolescents. The prescription of atypical antipsychotics to children is very common in developed countries. However, increased trend of atypical antipsychotics in use has also been paralleled by geometric progression in the incidence of intentional and non-intentional overdose. Although, the incidence of extrapyramidal symptoms were associated with lower therapeutic risperidone. In this juxtapose we present a case report findings of risperidone overdose presenting with acute dystonia at lower dosage. Since an overdose is commonly leads to neurological and cardiovascular involvement in children and also serial electrocardial monitoring is warranted. The treatment of risperidone overdose is mainly consists of gastric lavage, supportive therapy etc. Extrapyramidal symptoms were associated secondary to risperidone overdose, readily responds to anticholinergics. In Indian context, a very few case fatalities were reported.

Keywords:Risperidone; Overdose; Children; Acute Dystonia

×

References

  1. Isbister GK., et al. “Antipsychotic poisoning in young children: a systemic review”. Drug Safety 28 (2005): 1029-1044.
  2. Glatstein M., et al. “Severe Extrapyramidal Symptoms After Nonintentional Risperidone Exposure in a Child: Case Report and Review of the Literature”. American Journal of Therapeutics 18 (2011): 271-273.
  3. Kleigman RM., et al. “Nelson Textbook of Pediatrics”. 20th edition 2 (2016): 2892-2894.
  4. Kaur D., et al. “Accidental Ingestion of Risperidone in a Toddler with Autism”. MGM Journal of Medical Sciences 4 (2016): 210-211.
  5. Catalano G., et al. “Atypical antipsychotic overdose in the pediatric population”. Journal of Child and Adolescent Psychopharmacology 4 (2001): 425-434.
  6. Moore N and Shukla P. “Risperidone overdose”. The American Journal of Psychiatry 154 (1997): 289-290.
  7. Brunton LL., et al. “Goodman and Gilman’s The Pharmacological Basis of Therapeutics”.13th (2018): 283-293.
  8. Springfield A and Bodiford E. “An overdose of risperidone”. Journal of Analytical Toxicology 20 (1996): 202-203.
  9. Cheslik TA and Erramouspe J. “Extrapyramidal symptoms following accidental ingestion of risperidone in a child”. Annals of Pharmacotherapy 30 (1996): 360-363.
  10. Oslon KR. “Poisoning and Drug Overdose” 7 (2018): 130-132.
  11. Bishara D and Taylor D. “Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability”. Drugs 68 (2008): 2269-2292.
  12. Nasrallah HA. “Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles”. Molecular Psychiatry 13 (2008): 27-35.
×

Citation

Citation: Chikkanarasa Reddy PS., et al. “Risperidone Overdose with Acute Dystonia in Children - A Case Report”. Acta Scientific Paediatrics 3.7 (2020): 61-63.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor1.197

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US