Abstract

The concentration levels of As in the Chilean II Region of Antofagasta produces non cancer health outcomes such as cardiovascular diseases and in last term heart attack. On this study, the determination of total As content and main inorganic and organoarsenic species found in three heart tissues (auricle, mammary artery and fat) and the saphene vein of people living in the Chilean II Region, suffering coronary thrombosis has been carried out. Comparison with similar tissues of patients from other non-contaminated areas has been undertaken. The auricle and in less extend the saphene vein support the higher As concentration (mean values of 7.7 and 2.5 μg g^-1, respectively), being As(III) the predominant species. Methylation towards MMA and DMA is not a favoured mechanism. The presence of high total As and high As(III) species content in the auricle and saphene vein of more contaminated people, the damage found in the saphene vein tissue and the global characteristics of the people under study in which the As stigmas are present in all of them, suggests that As could be involved in the cardiovascular diseases.

Keywords:Arsenic Exposure; Cardiovascular Tissues; Arsenic Speciation; Total Arsenic Concentration: Medical Geology; Conditional Variables; Arsenic in Contaminated Cardiovascular Tissues

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Citation

Citation: Isabel Pizarro Veas., et al. “Arsenic Effects in Cardiovascular Diseases of People Living in Contaminated Areas of Chile".Acta Scientific Paediatrics 3.7 (2020): 39-45.

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Copyright: © 2020 Isabel Pizarro Veas., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.