Acta Scientific Paediatrics (ISSN: 2581-883X)

Research Article Volume 3 Issue 6

HIV Mother to Child Transmission-An Empirical and Cross Sectional Study

Gopalakrishna Mitra1, Asha Benakappa1and Basavarajaiah DM2*

1Department of Pediatrics, Bangalore Medical College and Research Institute, Bangalore, India
2Department of Pediatrics, Bangalore Medical College and Research Institute, Bangalore, India

*Corresponding Author: Basavarajaiah DM, Department of Stat and CS, KVAFSU, India.

Received: March 09, 2020; Published: May 31, 2020



Mother-to-child-transmission of HIV (HIV MTCT) is a major route of HIV infection in children. The literature cited that, the mother to Child transmission of HIV spread from a women living with HIV to her child during pregnancy, childbirth (also called labor and delivery) or of breast feeding (through breast milk). However, more number of study would be necessary for the implement the policy at worldwide. In this paradigm the present study to estimate the HIV transmission rate (HIV mother to child) in association with PMTCT and WHO guidelines on prospective and retrospective basis. A prospective and cross sectional study was conducted in the Department of Paediatrics, Bangalore Medical College and Research Institute during the period of (2013-14). A total 147 ANC’s were recruited with written consent and Institutional ethical clearance was obtained in accordance with stipulated WHO and NACO guidelines. The correlation between the HIV MTCT with or without ARV drug before and after delivery was analysed unpaired t-test, the research was prospectively studied with mean duration 2.5 - 3.0 years. The intervention of MTCT rate was recorded at regular follow up HAART therapy. As per the findings, the MTCT rate was found to be fewer percentage expression who received ARV drug before after pregnancy and results was found to be statistically significant differ (p < 0.01, chi-square 13.52; odd ratio 1.5 - 2.21) when compare to without ARV drugs. The mean CD4 count with ARV drug was 308 micro/dl and in case of without ARV mean CD4 count was 385.52 micro/dl. The infection rate was estimated with and without ARV it was found to be (5.74%) and (23.33%) respectively besides with WHO clinical stage III and IVth respectively. The present study concludes that, the strengthen the PMTCT guidlines to reduce the transmission risk of HIV MTCT. Abensece of ARV drug increase the transmssion rate at five fold more likely to transmit the disease.




  1. Basavarajaiah DM and Narasimha Murthy B. “Predictive Model Approach to HIV TB Co-infection in Vertical Transmission”. In: HIV Transmission. Springer, Singapore (2020).
  2. Basavarajaiah DM and Murthy Bhamidipati. “HIV Vertical Transmission DTSM Simulation Models: Global and National Perspective” (2020). 
  3. Misrahi M., et al. “CCR5 chemokine receptor variant in HIV-1 mother to child transmission and disease progression in children. French Pediatric HIV Infection Study Group”. The Journal of the American Medical Association 279.4 (1998): 277-280.
  4. Tresoldi E., et al. “Prognostic value of the stomal cell derived factor 1 3’A mutation in pediatric human immunodeficiency virus type 1 infection”. The Journal of Infectious Diseases 185.5 (2002): 696-700.
  5.  Department of AIDS control. “Ministry of Health and Family Welfare”. Annual Report 2018-19.
  6. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: recommendations for a public health approach. - 2010 version”. WHO (2010).
  7. Technical Report India. “HIV Estimates 2012”. National AIDS control Organisation (2012).
  8. Gottlieb MS. “Pneumocystis Pneumonia in Los Angeles”. Morbidity and Mortality Weekly Report 30.25 (1981): 250-252.
  9. Barre-Sinoussi F. “Isolation of a T-lymphotropic retrovirus from a patient at risk of acquired immune deficiency syndrome (AIDS)”. Science 220.4599 (1983): 865-867.
  10. Thomson MM and Najera R. “Molecular epidemiology of HIV-1 genetic forms and its significance for vaccine development and therapy”. The Lancet Infectious Diseases 2.8 (2002): 461-471.
  11. Liv R., et al. “Homozygous defect in HIV-1 co receptor accounts for resistance of some multiple-exposed individual to HIV-1 infection”. Cell 86 (1996): 367-377.
  12. Luzuriaga K., et al. “Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants”. Journal of Virology 73.1 (1999): 362-367.
  13. McIntosh K., et al. “Age and time related changes in extracellular viral load in children vertically infected by human immunodeficiency virus”. The Pediatric Infectious Disease Journal 15.12 (1996): 1087-1091.
  14. Palumbo PE., et al. “Predictive value of quantitative plasma HIV RNA and CD4+ lymphocyte count in HIV-infected infants and children”. The Journal of the American Medical Association 279.10 (1998): 756-761.
  15. Buseyne F., et al. “Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age”. The Journal of Infectious Diseases 178.4 (1998): 1019-1023.
  16. Singh KK., et al. “Genetic influence of CCR5, CCR2, and SDF-1 variants on human immunodeficiency virus-1 related disease progression and neurological impairment, in children with symptomatic HIV-1 infection”. The Journal of Infectious Diseases 188.10 (2003): 1461-1472.
  17. Cooper ER., et al. “Combination antiretroviral strategies for treatment of pregnant HIV infected women and prevention of perinatal HIV-1 transmission”. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 29 (2002): 484-494.
  18. The European Collaborative Study. “Maternal viral load and vertical transmission of HIV: an important factor but not the only one”. AIDS 13 (1999): 1377-1385.
  19. Leroy V., et al. “Twenty four month efficacy of a maternal short course zidovudine regimen to prevent mother-to-child transmission of HIV-1 in West Africa”. AIDS 16 (2002): 631-641.
  20. Rollins NC., et al. “Infant feeding, HIV transmission and mortality at 18 months: the need for appropriate choices by mothers and prioritization within programmes”. AIDS 22.17 (2008): 2349-2357.


Citation: Basavarajaiah DM., et al. “HIV Mother to Child Transmission-An Empirical and Cross Sectional Study”. Acta Scientific Paediatrics 3.6 (2020): 40-44.


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