Acta Scientific Paediatrics (ISSN: 2581-883X)

Case Report Volume 3 Issue 5

Pityriasis Rubra Pilar with Preceeding Herpes Infection in Childhood - Successful Treatment with Methotrexate

Priscilla Filippo Alvim de Minas Santos*

Hospital Municipal Jesus. Rio de Janeiro, RJ, Brazil

*Corresponding Author: Priscilla Filippo Alvim de Minas Santos, Hospital Municipal Jesus. Rio de Janeiro, RJ, Brazil.

Received: March 16, 2020; Published: May 04, 2020



 The Pityriasis rubra pilaris (PRP) is a rare, inflammatory, chronic disease of unknown etiology characterized by follicular papules, pinkish-yellow squamous plaques and palmoplantar keratoderma. The diagnosis clinical is most important and confirmed by biopsy of the skin. Many times, the same other clinical aspect could be confused such as psoriasis and atopic dermatitis. Currently, the first-line therapy is the systemic retinoid and other treatments, like methotrexate. The association with viral disease is uncommon. Our purpose was to report a case of PRP in a young boy associated with preceeding with primoinfection by herpes simplex with a favorable response to oral treatment with methotrexate and without recurrence after 10 months of follow-up.

Keywords: Methotrexate; Pityriasis Rubra Pilaris; Herpes Infection



  1. Polcari IC and Boyod AH. “Methotrexate treatment in a case of juvenile pityriasis rubra pilaris”. Pediatric Dermatology 1 (2017): e62-e63.
  2. Roenneberg S and Biedermann T. “Pityriasis rubra pilaris: algorithms for diagnosis and treatment”. Journal of the European Academy of Dermatology and Venereology 6 (2018): 889-898.
  3. Allison DS., et al. “Pityriasis rubra pilaris in children”. Journal of the American Academy of Dermatology 3 (2002): 386-389.
  4. Ross NA., et al. “Epidemiologic, Clinicopathologic, Diagnostic, and Management Challenges of Pityriasis Rubra Pilaris: A Case Series of 100 Patients”. JAMA Dermatology6 (2016): 670-675.
  5. Griffiths WAD. “Pityriasis rubra pilaris”. Clinical and Experimental Dermatology 1 (1980): 105-112.
  6. Miralles ES., et al. “Pityriasis rubra pilaris and human immunodeficiency virus infection”. British Journal of Dermatology 6 (1995): 990-993.
  7. Franzotti AM., et al. “Pitiríase Rubra Pilar e hipotireoidismo”. Anais Brasileiros de Dermatologia 3 (2014): 497-500.
  8. Ivanova K., et al. “Pityriasis rubra pilaris: treatment with biologics - a new promising therapy?” Dermatology2 (2012): 120-125.
  9. Alazemi A., et al. “Juvenile pityriasis rubra pilaris: successful treatment with methotrexate”. Clinical and Experimental Dermatology 1 (2017): 110-112.
  10. Genmmeke A., et al. “Pityriasis rubra pilaris - a retrospective single center analysis over eight years”. Journal der Deutschen Dermatologischen Gesellschaft 6 (2010): 439-444.


Citation: Priscilla Filippo Alvim de Minas Santos. “Pityriasis Rubra Pilar with Preceeding Herpes Infection in Childhood - Successful Treatment with Methotrexate”.Acta Scientific Paediatrics 3.5 (2020): 37-39.


Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor1.197

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