Acta Scientific Paediatrics (ISSN: 2581-883X)

Short Communication Volume 3 Issue 2

Neonatal Immunization

Richa Sharma*

Assistant Professor Paediatrics, Department of Paediatrics, SLBS GMC, Nerchowk Mandi, Himachal Pradesh, India

*Corresponding Author: Richa Sharma, Assistant Professor Paediatrics, Department of Paediatrics, SLBS GMC, Nerchowk Mandi, Himachal Pradesh, India.

Received: January 17, 2020; Published: January 31, 2020

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  Although vaccines have been quiet successful in reducing the large burden of serious infections. Neonates still remain quiet vulnerable to life-threatening infections. They take their greatest toll during the early stages of life. Hence various approaches are required to protect them. Here we review the rationale, current state, and research for such approach i.e neonatal immunization. There are many challenges to neonatal immunization. Few of them include concern regarding the safety of the vaccine and distinct neonatal immune system (vaccines which are effective in adults are not effective in new borns). Despite distinct neonatal immunity, there are several vaccines which have proven safe and effective at birth. However neonatal immunization at birth is quiet a reliable point of healthcare contact, so is an opportunity for early protection of neonates against diseases, including preterms which are deficient in passively transferred maternal antibodies. While some vaccines such as polysaccharide vaccines have little effectiveness at birth, hepatitis B vaccine can prime at birth and requires multiple doses to achieve protection, contrary to the BCG vaccine which, offers single shot protection.

Keywords: Neonatal; Vaccine; Protection; Immunity

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References

  1. Basha S., et al. “Immune responses in neonates”. Expert Review of Clinical Immunology 10 (2014): 1171-1184. 
  2. Plotkin Stanley A. “Vaccines: Correlates of vaccine-induced immunity”. Clinical Infectious Diseases 47 (2008): 401-409. 
  3. Permar SR., et al. “Role of CD8+ lymphocytes in control and clearance of measles virus infection of rhesus monkeys”. Journal of Virology 77 (2003): 4396-4400. 
  4. Permar SR., et al. “Increased thymic output during acute measles virus infection”. Journal of Virology 77 (2003): 7872-7879. 
  5. Slifka MK. “Immunological memory to viral infection”. Current Opinion in Immunology 16 (2004): 443-450. 
  6. Fletcher HA. “Correlates of immune protection from tuberculosis”. Current Molecular Medicine 7 (2007): 319-325. 
  7. Strikas RA., et al. “Advisory committee on immunization practices Advisory Committee on Immunization P, Group ACAIW. Advisory committee on immunization practices.
  8. Wood N and Siegrist CA. “Neonatal immunization: Where do we stand?” Current Opinion in Infectious Diseases 24 (2011): 190-195.
  9. Myers HI., et al. “A retrospective study of administration of vaccination for hepatitis b among newborn infants prior to hospital discharge at a Midwestern tertiary care center”. Vaccine 33 (2015): 2316-2321. 
  10. Cao LH., et al. “Efficacy of combined hepatitis B immunoglobulin and hepatitis B vaccine in blocking father-infant transmission of hepatitis B viral infection”. Genetics and Molecular Research 14 (2015): 4651-4657. 
  11. Fakharzadeh S., et al. “The new nano-complex, Hep-C, improves the immunogenicity of the hepatitis B vaccine”. Vaccine 31 (2013): 2591-2597. 
  12. Lambert L., et al. “Immunity to RSV in early-life”. Frontiers in Immunology 5 (2014): 466. 
  13. Zaghouani H., et al. “Neonatal immunity: Faulty T-helpers and the shortcomings of dendritic cells”. Trends in Immunology 30 (2009): 585-591. 
  14. Locht C and Mielcarek N. “New pertussis vaccination approaches: En route to protect newborns?” FEMS Immunology and Medical Microbiology 66 (2012):121-133. 
  15. Prevention CDC. “Guidelines for vaccinating pregnant women”. US Food and Drug Administration (2015). 
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Citation

Citation: Richa Sharma. “Neonatal Immunization”. Acta Scientific Paediatrics 3.2 (2020): 01-02.



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