Acta Scientific Paediatrics (ISSN: 2581-883X)

Research Article Volume 3 Issue 2

The Efficacy and Safety of Single Daily Dosing Ceftriaxone and Metronidazole vs the Triple Antibiotic Regimen for Complicated Appendicitis in Children

D Yardeni1*, R Billik4, L Siplovich1, B Kawar1, SE Golladay1, I Rosine1, M Zebidat1, H Polla1, Z Gwetta1, Y Ochayon1, A Pressman1, V Sacran2 and D Miron3

1Pediatric Surgery Department Ha’emek Medical Center, Afula, Israel
2Pediatric Department A, Ha’emek Medical Center, Afula, Israel
3Pediatric Department B, Ha’emek Medical Center, Afula, Israel
4Pediatric Surgery Department, Safra Children Hospital, Sheba Medical Center, Israel

*Corresponding Author: D Yardeni, Pediatric Surgery Department Ha’emek Medical Center, Afula, Israel.

Received: December 16, 2019; Published: January 22, 2020

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  Triple antibiotic therapy using ampicillin, gentamicin, and metronidazole (AGM) providing broad-spectrum coverage of gram-positive, gram-negative, and anaerobic bacteria, has been the standard treatment of complicated appendicitis in children.

Keywords:Ceftriaxone and Metronidazole; Safety; AGM; Appendicitis

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References

  1. St Peter SD., et al. “A simple and more cost effective antibiotic regimen for perforated appendicitis”. Journal of Pediatric Surgery 41.5 (2006): 1020-1024. 
  2. Aziz O., et al. “Laparoscopic versus open appendectomy in children: a meta-analysis”. Annals of Surgery 243.1 (2006): 17-27.
  3. Clay PG., et al. “Clinical efficacy, tolerability, and cost savings associated with the use of open-label metronidazole plus ceftriaxone once daily compared with ticarcillin and clavulanate every 6 hours as empiric treatment for diabetic lower-extremity infections in older males”. The American Journal of Geriatric Pharmacotherapy 2 (2004): 181-189.
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  8. McBurney C. “The incision made in the abdominal wall in cases of appendicitis, with a description of a new method of operating”. Annals of Surgery 20 (1894): 38. 
  9. Oliak D., et al. “Nonoperative management of perforated appendicitis without periappendiceal mass”. American Journal of Surgery 179.3 (2000): 177-181.
  10. Samelson SL and Reyes HM. “Management of perforated appendicitis in children-revisited”. Archives of Surgery 122.6 (1987): 691-696.
  11. Sprandel KA., et al. “Pharmacokinetics and pharmacodynamics of intravenous levofloxacin at 750 milligrams and various doses of metronidazole in healthy adult subjects”. Antimicrobe Agents Chemotherapy 48.12 (2004): 4597-4605.
  12. Weiner DJ. “Interval appendectomy in perforated appendicitis”. Pediatric Surgery International 10 (1995): 82. 
  13. Yamini D., et al. “Perforated appendicitis: is it truly a surgical urgency?” American Surgeon 64.10 (1998): 970-975.
  14. Shawn D., et al. “Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial”. Journal of Pediatric Surgery 43 (2008): 981-985.
  15. Bufo AJ., et al. “Interval appendectomy for perforated appendicitis in children”. Journal of Laparoendoscopic and Advanced Surgical Technique 8.4 (1998): 209-214.
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Citation

Citation: D Yardeni., et al. “The Efficacy and Safety of Single Daily Dosing Ceftriaxone and Metronidazole vs the Triple Antibiotic Regimen for Complicated Appendicitis in Children”. Acta Scientific Paediatrics 3.2 (2020): 01-06.



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