Acta Scientific Paediatrics (ISSN: 2581-883X)

Research Article Volume 3 Issue 2

Pregnancy Outcome in Fresh and Frozen Embryo Transfer in Women with High Estradiol Levels

Archana S*, G Shiva Krishna, Vijalakshmi, Devika Gunasheela

Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, India

*Corresponding Author: Archana S, Research Scholar, Department of Human Genetics, Faculty of Biomedical Sciences, Technology and Research, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, India.

Received: December 13, 2019; Published: January 06, 2020


  Exogenous elevation of serum estradiol shortly after the time of ovulation is known to reduce the endometrial receptivity in natural cycle. High serumestradiol may affect the synthesis and secretion of glycogen by endometrial epithelial cells. Studies on endometrial morphology, biochemistry and endometrial genomic pattern at the time of implantation showed that high estradiol may negatively affect the endometrial receptivity during infertility treatment. Highestradiol is one of the contributing factors for OHSS.

  Controlled Ovarian Hyperstimulation (COH) creates a supraphysiologic environment which affects endometrial receptivity. Frozen embryo transfer avoids supraphysiological environment which alters the endometrial receptivity. Endometrial development can be controlled precisely in frozen embryo transfer cycle than in COH with gonadotropins.

Keywords:Pregnancy; Estradiol; Frozen Embryo Transfer



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Citation: Archana S., et al. “Pregnancy Outcome in Fresh and Frozen Embryo Transfer in Women with High Estradiol Levels”. Acta Scientific Paediatrics 3.2 (2020): 03-06.


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