The gut microbiome

  All the microorganisms and their genomes that reside in human intestinal tract are referred to as the gut microbiome. Research reveals that they regulate various physiological processes such as immunomodulation, adiposity, energy balance. They also play a significant role in regulating the electrophysiological activity of enteric nervous system(ENS) [1].

The bidirectional brain-gut axis

  The complex two way signalling that happens between the brain and the gastrointestinal tract is delimited at hormonal, neural, and immunological levels. This paradigm is acknowledged as the brain-gut axis. The signals from central nervous system (CNS) affects the sensory, motor, and secretory functions of the GIT and visceral signals from intestinal tract has affects the neurological functions. The brain–gut axis is essential for sustaining the homeostasis [2].

References

1. Sarkar A., et al. “Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals”. Trends in Neuroscience11 (2016): 763-781.
2. Grenham S., et al. “Brain-gut-microbe communication in health and disease”. Frontiers in Physiology 2 (2011): 94.
3. Mayer EA. “Gut feelings: the emerging biology of gut-brain communication”. Nature Reviews in Neuroscience8 (2011): 453-466.
4. Sansonetti PJ and Medzhitov R. “Learning tolerance while fighting ignorance”. Cell 138 (2009): 416-420.
5. Petra AI., et al. “Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders with Suspected Immune Dysregulation”. Clinical Therapy5 (2015): 984-995.
6. De Lorenzo A., et al. “Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial”. Journal of Translational Medicine 1 (2017): 135.
7. Patra S. “Psychobiotics: A paradigm shift in psychopharmacology”. Indian Journal of Pharmacology4 (2016): 469-470.

Citation

Citation: Divya R and Ashok V. "Eat Bacteria to Cure Mental Illness; The New Era “Psychobiotics” vs the Current Era Psychotropics".Acta Scientific Pharmacology 1.1 (2020): 01-02.

Copyright

Copyright: © 2020 Divya R and Ashok V. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.