*Corresponding Author: Sharadendu Bali, MS (General Surgery), PhD (Biochemistry); Professor, General Surgery, TMMC, TMU, Moradabad, UP, India.

Received: March 26, 2025; Published: March 31, 2025

Abstract

Citrus limon (C. Limon), commonly known as lemon, represents one of the most significant crops in fruit production. Its unique tangy flavor lends itself to diverse culinary and beverage applications, including use in desserts, ice creams, beverages, and as a quintessential cooking ingredient. This review aims to synthesize the existing literature on the neuroprotective effects of phytochemicals present in lemon pickle, a traditional condiment made from Citrus limon. We extracted data from published studies that examine a wide array of phytochemicals found in lemon, including nobiletin, hesperidin, hesperetin, naringin, naringenin, rutin, heptamethoxyflavone (HMF), tangeretin (TGN), quercetin, limonene, eriodictyol, isoimperatorin (IMP), apigenin, luteolin, and vitamin C. This review focuses on in-vitro, animal, and human clinical studies exploring the impact of these phytochemicals on neurodegenerative diseases. Our findings showed that Phytochemicals found in lemon pickle demonstrate multi-targeted mechanisms that have the potential to ameliorate various aspects of neurodegenerative diseases. These include decreasing oxidative stress, anti-neuroinflammatory effects, modulation of multiple signaling pathways, and protection against neurotoxicity. In human clinical trials, consumption of citrus phytochemicals was associated with improvements in cognitive performance and other biomarkers, although the underlying mechanisms were not consistently specified. In conclusion, lemon pickle emerges as a promising dietary inclusion that offers a plethora of neuroprotective phytochemicals. Their collective intake through lemon pickle consumption could offer a simple strategy for reducing the risk of neurodegenerative diseases and improving brain health.

Keywords: Neuroprotective; Lemon Pickle; Citrus limon; Citrus Phytochemicals; Neurodegenerative Diseases; Cognitive Function; Nimbu Achar; Neurotherapeutic Spices

References

1. Faaiz Ali Shah and Ashok Shyam. “Non-metallic Fixation of Patella Fractures: A Paradigm Shift”. Journal of Orthopaedic Case Reports 8 (2023): 1-3.
2. Lawrence Camarda., et al. “Non-metallic implant for patellar fracture fixation: A systematic review”. Injury 8 (2016): 1613-1617.
3. Rovere Giuseppe., et al. “Nonmetallic tension band fixation is a viable and low complication surgical technique in patellar fractures: a five year retrospective”. European Journal of Orthopaedic Surgery and Traumatology 4 (2024): 2065-2071.
4. Daran Huang., et al. “Metal vs non-metal fixation methods for patellar fractures: A systematic review and meta-analysis of clinical and radiographic outcome”. Journal of Clinical Orthopaedics and Trauma 47 (2023): 102314.

Citation

Citation: BA Gopala Krishna. “Non-Metallic Stabilization of Orthopaedic Injuries-A Case Study".Acta Scientific Orthopaedics 8.4 (2025): 07-11.

Copyright

Copyright: © 2025 BA Gopala Krishna. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.