Seyed Amirhossein Dormiani Tabatabaei*

Isfahan University of Medical Sciences isfahan, Iran

*Corresponding Author: Seyed Amirhossein Dormiani Tabatabaei, Isfahan University of Medical Sciences isfahan, Iran.

Received: September 05, 2023; Published: October 23, 2023

Abstract

Objective: In this essay, the manifestations, possible etiologies, diagnostic approachs, treatment methods and complications of lipomas are reviewed.

Methods: A thorough review of the literature is conducted, a series of 12 patients are outlined and briefly examined.

Results: Lipomas may present as asymptomatic tumors or produce distressing signs and symptoms such as pain, swelling and overgrowth. Some lipomas may be identified by physical examination alone. However. magnetic resonance imaging (MRI) is the conclusive method of evaluation especially in deeper lesions.

Conclusions: In the absence of indications or cosmetic concerns, observation stays the standard of care. When pain, itching, compression symptoms or disfigurement impress the patient, surgical removal and pathology assessment are typically recommended. Malignant transformation rarely occurs.

Keywords: Neoplasms; Lipoma; Pathology

References

1. Kosztyuova T and Shim TN. “Rapidly enlarging lipoma”. BMJ Case Reports (2017).
2. Johnson CN., et al. “Lipomatous Soft-tissue Tumors”. Journal of the American Academy of Orthopaedic Surgeons 22 (2018): 779-788.
3. McFarland GB and Hoffer MM. “Paralysis of the intrinsic muscles of the hand secondary to lipoma in Guyon’s tunnel”. Journal of Bone and Joint Surgery-American Volume 2 (1971): 375-376.
4. Brodovsky S., et al. “Adiposis dolorosa (Dercum’s disease): 10-year follow-up”. Annals of Plastic Surgery 6 (1994): 664-668.
5. Vásquez Elera L., et al. “[Familiar adenomatous polyposis: report of 2 cases]”. Revista de Gastroenterología del Perú 1 (2018): 78-81.
6. Baldino ME., et al. “Gardner syndrome with maxillofacial manifestation: A case report”. Special Care in Dentistry 1 (2019): 65-71.
7. Creytens D. “A contemporary review of myxoid adipocytic tumors”. Seminars in Diagnostic Pathology 2 (2019): 129-141.
8. Charifa A., et al. “Lipoma Pathology”. In: StatPearls. Treasure Island (FL): StatPearls Publishing (2022).
9. Weiss SW and Goldblum JR. “Benign Lipomatous Tumors”. In: Enzinger FM, Weiss SW, eds. Soft Tissue Tumors. 3^rd St Louis, Mo: Mosby (1995): 381-430.
10. Phalen GS., et al. “Lipomas of the upper extremity: a series of fifteen tumors in the hand and wrist and six tumors causing nerve compression”. The American Journal of Surgery 3 (1971): 298-306.
11. Rydholm A and Berg NO. "Size, site and clinical incidence of lipoma. Factors in the differential diagnosis of lipoma and sarcoma". Acta Orthopaedica Scandinavica 6 (1983): 929-934. 
12. Salam GA. "Lipoma excision". American Family Physician 5 (2018): 901-904. 
13. Panagopoulos I., et al. “Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12) (p22;q14)”. Diagnostic Pathology 11 (2016): 22.
14. Ameloot E., et al. “Update of Pediatric Lipomatous Lesions: A Clinicopathological, Immunohistochemical and Molecular Overview”. Journal of Clinical Medicine 7 (2022): 1938.
15. Chrisinger JSA. “Update on Lipomatous Tumors with Emphasis on Emerging Entities, Unusual Anatomic Sites, and Variant Histologic Patterns”. Surgical Pathology Clinics 1 (2019): 21-33.
16. Berkovic SF., et al. “Mitochondrial dysfunction in multiple symmetrical lipomatosis”. Annals of Neurology5 (1991): 566-569.
17. Leiva SF., et al. “Lipoma in the thyroid?” Journal of Pediatric Endocrinology and Metabolism 7 (2004): 1013-1015.
18. Weinberg T and Feldman M. “Lipomas of the gastrointestinal tract”. American Journal of Clinical Pathology3 (1955): 272-281.
19. Miyake O., et al. “[Adrenal myelolipoma associated with Cushing’s syndrome: a case report]”. Hinyokika Kiyo6 (1992): 4-681.
20. Clayman E., et al. “Corticosteroid-Associated Angiolipomatosis”. Eplasty 17 (2017): ic9.
21. Garfinkel HA. “A massive lipoma in a patient receiving chlorpropamide therapy”. Postgraduate Medical Journal 544 (1971): 137-138.
22. Brooke RI and MacGregor AJ. “Traumatic pseudolipoma of the buccal mucosa”. Oral Surgery, Oral Medicine, Oral Pathology2 (1969): 223-225. 
23. Meggitt BF and Wilson JN. “The battered buttock syndrome: fat fractures: a report on a group of traumatic lipomata”. British Journal of Surgery 59 (1972): 165-169.
24. Herbert DC and DeGeus J. “Post-traumatic lipomas of the abdominal wall”. British Journal of Plastic Surgery 28 (1975): 303-306.
25. Copcu E. “Can intramuscular lipoma have a post‐traumatic origin”. British Journal of Dermatology 5 (2003): 1084-1085.
26. Tiao WM., et al. “Lipoma arborescens of the knee: a case report”. Journal of the Formosan Medical Association 100 (2001): 412-415.
27. Cohen S., et al. “Post-traumatic soft tissue tumors: case report and review of the literature a propos a post-traumatic paraspinal desmoid tumor”. World Journal of Surgical Oncology 6 (2008): 28.
28. Ewing J. “Buckley lecture: Modern attitude toward traumatic cancer”. Archives of Pathology 19 (1935): 690.
29. Posch JL. “Tumors of the hand”. Journal of Bone and Joint Surgery-American Volume 38-A.3 (1956): 517-539.
30. Leffert RD. “Lipomas of the upper extremity”. Journal of Bone and Joint Surgery-American Volume 6 (1972): 1262-1266.
31. James JJ., et al. “The Breast”. In: Adam A, Dixon AK, eds. Grainger and Allison’s Diagnostic Radiology. 5^th Philadelphia, Pa: Elsevier (2008).
32. Weekes RG., et al. “CT of soft-tissue neoplasms”. American Journal of Roentgenology2 (1985): 355-360.
33. Egund N., et al. “CT of soft-tissue tumors”. American Journal of Roentgenology4 (1981): 725-729.
34. Lee YH., et al. “Intramuscular lipoma in thenar or hypothenar muscles”. Hand Surgery 1 (2004): 49-54.
35. Lichon S and Khachemoune A. “Clinical presentation, diagnostic approach, and treatment of hand lipomas: a review”. Acta Dermatovenerol Alp Pannonica Adriat 3 (2018): 137-139.
36. Datir A., et al. “MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis”. Clinical Radiology 4 (2008): 373-378.
37. Bancroft LW., et al. “Benign fatty tumors: classification, clinical course, imaging appearance, and treatment”. Skeletal Radiology 10 (2006): 719-733.
38. Amber KT., et al. “Injection therapy for the management of superficial subcutaneous lipomas”. The Journal of Clinical and Aesthetic Dermatology 6 (2014): 46-48.
39. Redman LM., et al. “Association of β-2 adrenergic agonist and corticosteroid injection in the treatment of lipomas”. Diabetes, Obesity and Metabolism 6 (2011): 517-522.
40. Kopera D., et al. “Intralesional lipolysis with phosphatidylcholine for the treatment of lipomas: pilot study”. Archives of Dermatological 3 (2006): 395-396.
41. Sawhney KK., et al. “Liposarcoma of the hand”. American Surgeon 2 (1957): 117-120.
42. Sampson CC., et al. “Liposarcoma developing in a lipoma”. Archives of Pathology 69 (1960): 506-510.
43. MJ, Naqvi AH., et al. “Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors”. Skeletal Radiology 5 (2005): 272-278.
44. Mack LA., et al. “Preoperative chemoradiotherapy (modified Eilber protocol) provides maximum local control and minimal morbidity in patients with soft tissue sarcoma”. Annals of Surgical Oncology 8 (2005): 646-653.
45. Loubignac F., et al. “Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance”. World Journal of Surgical Oncology 7 (2009): 42.

Citation

Citation: Seyed Amirhossein Dormiani Tabatabaei. “Lipoma; A Common Benign Neoplasm"Acta Scientific Orthopaedics 6.11 (2023): 52-59.

Copyright

Copyright: © 2023 Seyed Amirhossein Dormiani Tabatabaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.