Michael Fitzmaurice M.D*

Fitzmaurice Hand Institute and BioMed Rejuvenation Anti-Aging Clinic, United States

*Corresponding Author: Michael Fitzmaurice M.D, Fitzmaurice Hand Institute and BioMed Rejuvenation Anti-Aging Clinic, United States.

Received: September 20, 2023; Published: September 29, 2023

Abstract

Peripheral neuropathy effects 100’s of millions of individuals and causes significant pain. Treatment option have been limited and medications often cause significant side effects limiting their use. Certain supplements have been demonstrated some benefit to patients with neuropathic pain with decreased pain and improved nerve function. Bromelain is one of these supplements and we review the benefits of using bromelain to patients with neuropathic pain.

Keywords: Bromelain; Nerve; Neuropathy; Neuropathic Pain; Supplement

References

1. Wiffen PJ., et al. “Gabapentin for chronic neuropathic pain in adults”. Cochrane Database of Systematic Reviews6 (2017).
2. Bakare AO and Owoyele BV. “Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats”. The Korean Journal of Pain 1 (2020): 13-22.
3. Durrenberger PF., et al. “Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study”. BMC Neurology1 (2006): 1.
4. Takahashi M., et al. “Cyclooxygenase-2 expression in Schwann cells and macrophages in the sciatic nerve after single spinal nerve injury in rats”. Neuroscience Letters 3 (2004): 203-206.
5. Muja N and DeVries GH. “Prostaglandin E (2) and 6-keto-prostaglandin F (1alpha) production is elevated following traumatic injury to sciatic nerve”. Glia 2 (2004): 116-129.
6. Kaltschmidt B., et al. “Cyclooxygenase-2 is a neuronal target gene of NF-κB”. Bmc Mol Biol 1 (2002): 16.
7. Bhui K., et al. “Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway”. Cancer Letters 2 (2008): 167-176.
8. Bakare AO and Owoyele BV. “Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in sciatic nerve ligated Wistar rats”. Scientific Reports (SCI REP-UK) 1 (2021): 289.
9. Bakare A and Owoyele B. “Bromelain Reduced Nitrite and Nfк-B Level as a Mechanistic Underpin of its Antinociceptive Effect on Sciatic Nerve Ligation Model of Neuropathic Pain in Wistar Rats”. Ibro Reports 7 (2019): 7.
10. Bakare AO and Owoyele BV. “Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats”. Naunyn-Schmiedeberg’s Archives of Pharmacology 1 (2019): 147.
11. Marvulli R., et al. “Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome”. Endocrine, Metabolic and Immune Disorders - Drug Targets (2020): 20.
12. Fitzmaurice MJ. “The Effect of NeuroGen^® Nerve Support Supplement on Pillar Pain after Endoscopic Carpal Tunnel Release”. Modern Plastic Surgery 04 (2013): 1-6.

Citation

Citation: Michael Fitzmaurice M.D. “Bromelain as a Therapeutic Option for Treatment of Neuropathic Pain".Acta Scientific Orthopaedics 6.10 (2023): 83-85.

Copyright

Copyright: © 2023 Michael Fitzmaurice M.D. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.