Muscle and Knee Osteoarthritis: “What’s New” in 2023
Osteoarthritis Research Center, Canada
*Corresponding Author: Ray Marks, Osteoarthritis Research Center, Canada.
August 11, 2023; Published: August 25, 2023
Osteoarthritis, the most common joint disease experienced by many older adults and one that is increasing as societies age remains largely incurable and highly disabling. As such, and in light of the failure of most palliative pharmacologic strategies to date to reverse or mitigate this painful condition, it appears all avenues of potential progress added to those already being explored may yet prove fruitful. Based on emerging and quite promising data outlining a possible link between aspects of osteoarthritis joint damage and muscle deficits, this mini-review elected to examine the most current data in regard to discern whether: 1) Muscle dysfunction continues to be an important potentially modifiable health determinant whose presence might influence the onset and progression of osteoarthritis through direct as well as indirect pathways, and 2) any evidence pointing to its possible detection, categorization, and remediation as being desirable in this regard if indicated. Based on the bulk of available data housed in PUBMED, GOOGLE SCHOLAR, Science Direct, and PubMed Central as of August 15, 2023, it is concluded that a causative, mediating or moderating role for muscle dysfunction in the realm of osteoarthritis cannot be ignored as per data related to its most common form, knee osteoarthritis. Future efforts to advance this line of inquiry that proceed from a multi component muscle specific and whole joint perspective of osteoarthritis disability may prove of immense personal and societal impact and benefit.
Keywords: Aging; Muscle; Knee Osteoarthritis; Pathology; Prevention; Treatment
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