Acta Scientific Orthopaedics (ISSN: 2581-8635)

Review Article Volume 6 Issue 5

Association Of ABO Blood Groups with Malocclusion: A Narrative Review

Anup Kanase*, Shruti Mathur, Tulika Tripathi and Priyank Rai

Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Science, New Delhi, India

*Corresponding Author: Anup Kanase, Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Science, New Delhi, India.

Received: March 10, 2023; Published: April 23, 2023


Malocclusion has a multifactorial aetiology and can be attributed to local as well as general factors. Genetics plays a significant role in aetiology of malocclusion. Malocclusion is considered as a quantitative genetic trait with continuous graded distribution in the population. Association between various oral diseases with ABO blood groups have been established in the past. ABO blood groups are one of the most important human genetic traits that follows Mendalian inheritance. Since both the ABO blood groups and malocclusion are genetic traits, authors have carried out studies to assess if association between the two exists. The purpose of this narrative review is to enumerate studies that have assessed the association between dental, skeletal malocclusions with the ABO blood groups.

Keywords: Skeletal Malocclusion; Dental Malocclusion; ABO Blood Groups


  1. Alhammadi MS., et al. “Global distribution of malocclusion traits: A systematic review”. Dental Press Journal of Orthodontics (2018): 40-e41.
  2. Houston WJ., et al. “A textbook of orthodontics”. Wright (1992).
  3. Kharbanda OP. “Orthodontics: Diagnosis and Management of Malocclusion and Dentofacial Deformities, E-Book”. Elsevier Health Sciences (2019).
  4. Agarwal SS., et al. “An overview of malocclusion in India”. Journal of Dental Health, Oral Disorders and Therapy 3 (2015): 00092.
  5. Mossey PA. “The heritability of malocclusion: Part 1-Genetics, principles and terminology”. British Journal of Orthodontics2 (1999): 103-113.
  6. Mossey PA. “The heritability of malocclusion: part 2. The influence of genetics in malocclusion”. British Journal of Orthodontics3 (1999): 195-203.
  7. Daniel G. “Human blood groups. 2nd edition”. Oxford: Blackwell (2002): 3-8.
  8. Schwarz HP and Dorner F. “Karl Landsteiner and his major contributions to haematology”. British Journal of Haematology4 (2003): 556-565.
  9. Lewis M., et al. “Genetic linkage analyses of chromosome 9 loci ABO and AK1”. Cytogenetic and Genome Research1-6 (1978): 452-455.
  10. Sharma R., et al. “Association of ABO Blood Groups with Malocclusion in Population of Jaipur, India: a prospective study”. International Journal of Scientific Study11 (2015): 45-51.
  11. Gupta P., et al. “Correlation of ABO and Rh Blood Group with Dental Malocclusion in Population of Mysuru”. Dental Hypotheses2 (2020): 47.
  12. Rashid A and El Feky H. “Correlation between ABO Blood Groups and Malocclusion in a sample of Egyptian Populations: A cross sectional study”. Egyptian Dental Journal 65 (2019): 875-880.
  13. Tariq B., et al. “Gender wise association between dental malocclusion classes and ABO blood group system”. Dentistry532 (2019): 2161-1122.
  14. Al-Khatieeb MM., et al. “Association of ABO blood group and rhesus factor with dental malocclusion in a population of Baghdad, Iraq”. International Journal of Medical Research and Health Sciences 7 (2018): 165-169.
  15. Gupta SP. “Association of ABO blood groups with occlusal pattern among Orthodontic patients of Kathmandu district”. Journal of Institute of Medicine Nepal12 (2018): 2119-2129.
  16. Gheisari R., et al. “The association between blood groups and maxillofacial deformities”. Indian Journal of Plastic Surgery02 (2008): 138-140.
  17. Schnibben Charles Louis. "A Study of the Relationships of the ABO Human Blood Groups, the Rh Factor and Hereditary Malocclusions of the Skeletal Type, Class II, Division 1" (1968). Master's Theses. Paper (1969):
  18. Flannery Patrick Michael. "The Abo Human Blood Groups and Skeletal Class IIi Malocclusions". Master's Theses (1969):
  19. Shokor FF., et al. “Craniofacial morphology with genetic influence of ABO blood Group in malaysian orthodontic patients”. International Journal of Pharma and Bio Sciences4 (2015): 412-418.
  20. Datana SS and Bhandari S. “Correlating Vertical Skeletal Patterns with ABO Blood Grouping System: A Cross-Sectional Study”. Journal of Contemporary Orthodontics3 (2019): 33-37.
  21. Rathi A., et al. “Association of ABO blood group with crowding among patients with different malocclusions”. Journal of Dentistry Defence Section1 (2020): 4.
  22. Johns G. “Association of blood groups with malocclusion”. International Dental Journal of Student's Research 3 (2021): 133-139.
  23. Koregol AC., et al. “ABO blood groups and Rhesus factor: An exploring link to periodontal diseases”. Indian Journal of Dental Research3 (2010): 364.
  24. Vivek S., et al. “Association of ABO Blood Group and Rh factor with periodontal disease in a population of Virajpet, Karnataka: A cross-sectional study”. Journal of International Oral Health: JIOH4 (2013): 30.
  25. Mortazavi H., et al. “ABO blood groups in oral cancer: a first case-control study in a defined group of Iranian patients”. Asian Pacific Journal of Cancer Prevention3 (2014): 1415-1418.
  26. Cunha A., et al. “Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns”. Archives of Oral Biology 97 (2019): 85-90.
  27. Da Fontoura CG., et al. “Candidate gene analyses of skeletal variation in malocclusion”. Journal of Dental Research7 (2015): 913-920.
  28. Huh A., et al. “Epigenetic influence of KAT6B and HDAC4 in the development of skeletal malocclusion”. American Journal of Orthodontics and Dentofacial Orthopedics4 (2013): 568-576.


Citation: Anup Kanase., et al. “Association Of ABO Blood Groups with Malocclusion: A Narrative Review”.Acta Scientific Orthopaedics 6.5 (2023): 92-96.


Copyright: © 2023 Anup Kanase., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate33%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US