Khaled Kamoun¹*, Imed Mdhafer¹, Khaled Khelil¹, Faten Farah² and Mourad Jenzri¹

¹Pediatric Orthopedics Department, KASSAB Institute, El Manar University Tunis
²Pathology Department, KASSAB Institute, El Manar University Tunis

*Corresponding Author: Khaled Kamoun, Pediatric Orthopedics Department, KASSAB Institute, El Manar University Tunis.

Received: December 06, 2022; Published: January 13, 2023

Abstract

Giant cell tumors (GCTs) are rare tumors and represent 5 to 10% of all primary bone tumors. Those tumors are rare before skeletal maturity (1.7-2.5%). They appear as an expansile lytic lesions involving the metaphyso-epiphyseal area of long bones. We report a metaphyso-epiphyseal upper tibia location in a 13-year-old boy treated by curettage followed by calcitonin protocol injections with 13 years follow-up.
Skeleton GCTs are highly uncommon in pediatric age group. Calcitonin therapy for GCTs in children has not been reported in the literature. This protocol can be an interesting alternative treatment for these tumor locations.

Keywords: Giant Cell Tumors; Pediatrics; Calcitonin; Tumor

References

1. Blackley HR., et al. “Treatment of giantcelltumors of long bones with curettage and bone-grafting”. Journal of Bone and Joint Surgery 81 (1999): 811-820.
2. Turcotte RE., et al. “Giant cell tumor of long bone: a Canadian Sarcoma Group study”. Clinical Orthopaedics 397 (2002): 248-258.
3. Puri A., et al. “Management of Giant Cell Tumour Radius in a Three-Year-old Child with an Improvised Technique”. JCDR12 (2014): QD04-6.
4. PICCI P., et al. “Giant-cell tumor of bone in skeletally immature patients”. The Journal of Bone and Joint Surgery. American 65 (1983): 486-490.
5. J MINGUELLA. “Giant cell tumour of metacarpal in a child of unusual site and age”. The Hand 1 (1982): 93-96.
6. Sait SA., et al. “Giant cell tumour of the distal humerustreated with elbow arthroplasty: a case report”. International Journal of Case Reports and Images 3 (2012): 37-40.
7. Jundt G. “Pathologic - anatomic characteristics of benign bone tumors”. Orthopade 1 (1995): 2-14.
8. DAHLIN DC. “Case Report 9”. Skeletal Radiology 1 (1976): 117-118.
9. Prosser GH., et al. “Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone?” Clinical Orthopaedics and Related Research 435 (2005): 211-218.
10. Kivioja AH., et al. “Cement is recommendedin intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years”. Acta Orthopaedica 1 (2008): 86-93.
11. Wang HC., et al. “Management of grade III giant cell tumors of bones”. Journal of Surgical Oncology 1 (2005): 46-51.
12. Prosser GH., et al. “Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone?” Clinical Orthopaedics and Related Research 435 (2005): 211-218.
13. Harris M. “Central giant cell granulomas of the jaws regress with calcitonin therapy”. British Journal of Oral and Maxillofacial Surgery 31 (1993): 89-94.
14. De Lange J., et al. “Calcitonin therapy in central giant cell granuloma of the jaw: a randomized doubleblind placebo-controlled study”. International Journal of Oral and Maxillofacial Surgery 35 (2006): 791-795.
15. Nouri H., et al. “Calcitonin use in giant cell bone tumors (2011).
16. Kivioja AH., et al. “Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years”. Acta Orthopaedica 79 (2008): 86-93.
17. Chang SS., et al. “Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis”.Clinical Orthopaedics and Related Research 426 (2004): 103-109.
18. Saiz P., et al. “Results of giant cell tumor of bone treated with intralesional excision”. Clinical Orthopaedics and Related Research 424 (2004): 221-226.
19. Dridi M., et al. “Metatarsal Giant cell tumour in a 7-yearold child: A case report”. Acta Orthopaedica Belgica6 (2017): 843-846.

Citation

Citation: Khaled Kamoun., et al. “Calcitonin Protocol Therapy for a Treatment of a Bone Giant Cell Tumor in Childhood: A Case Report”.Acta Scientific Orthopaedics 6.2 (2023): 37-40.

Copyright

Copyright: © 2023 Khaled Kamoun., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.