Acta Scientific Orthopaedics (ISSN: 2581-8635)

Research Article Volume 6 Issue 2

Antibiotic Elution from Cement: An In Vitro Study

Christy Graff1*, Rebecca Tang2 and Bradley Crick3

1Department of Orthopaedics, The University of Adelaide, The Women’s and Children’s Hospital, North Adelaide, The Royal Adelaide Hospital, Adelaide, Australia
2Austin Hospital, Victoria, Australia
3Frankston Hospital, Victoria, Australia

*Corresponding Author: Christy Graff, Department of Orthopaedics, The University of Adelaide, The Women’s and Children’s Hospital, North Adelaide, The Royal Adelaide Hospital, Adelaide, Australia.

Received: November 29, 2022; Published: January 10, 2023

Abstract

Prosthetic joint infection is a serious complication of total hip replacement. Cement removal during two stage revisions can be associated with significant morbidity. Exposing new surface area of cement may achieve therapeutic antibiotic elution.
Five blocks containing polymethylmethacrylate (PMMA) and vancomycin were stored in normal saline at 37oC and allowed to reach steady state. Different interventions to expose new surface area were performed at six weeks.
Post intervention, blocks with the greatest increase in surface area showed the greatest increase in vancomycin levels, the highest increase being 641.77% compared with the control (5.88%).
This study confirms antibiotics remain trapped within PMMA after elution ceases. Further release of vancomycin from cement occurs after exposing new surface area. This seems proportional to the exposed surface area size.

Keywords: Cement; Antibiotic; Elution; Total Hip Replacement; Infection

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Citation

Citation: Christy Graff., et al. “Antibiotic Elution from Cement: An In Vitro Study”.Acta Scientific Orthopaedics 6.2 (2023): 24-30.

Copyright

Copyright: © 2023 Christy Graff., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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