Acta Scientific Orthopaedics (ISSN: 2581-8635)

Research Article Volume 6 Issue 1

Efficacy of sCOMP in Diagnosing Knee Osteoarthritis

Sudhir Singh1*, Chetan Verma2 and Lal Shrikant Kaushik2

1Professor, Department of Orthopaedics, Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India
2Resident, Department of Orthopaedics, Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India

*Corresponding Author: Sudhir Singh, Professor, Department of Orthopaedics, Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India.

Received: November 03, 2022; Published: December 14, 2022

Abstract

Objective: The goal of this study was to establish the utility of serum Cartilage Oligomeric Matrix Protein (sCOMP) as a biomarker for differentiating between disease severity grades of knee osteoarthritis (KOA).

Material and Method: Patients of osteoarthritis of knee were included as Cases (100 subjects) and normal adults were taken as Controls (50 subjects). Clinical, radiological and biochemical assessment was done by WOMAC score, knee radiograph and blood sample for sCOMP respectively.

Results: Results show WOMAC Score was significantly higher in cases (49.97 ± 17.98) than in Controls (11.24 ± 06.07) (p < 0.001). Mean sCOMP level was significantly higher in Case group than in Control group (17.38 ± 4.99 U/L vs 1.16 ± 0.39 U/L; p = 0.001). sCOMP increases with increasing K-L grades except in grade III. In Case group sCOMP was 14.60 ± 6.47 U/L in K-L grade I; as 17.47 ± 4.99 U/L in K-L grade II; as 17.25 ± 4.63 U/L in K-L grade III and as 19.77 ± 4.65 U/L in K-L grade IV. One-way ANOVA of K-L Grade with sCOMP (F = 1.55, p = 0.02) and with WOMAC score (F = 20.18, p = 0.001) show significant association. Pearson Correlation and coefficient (r) value show that Age has moderate positive and significant co-relation with WOMAC Score (r = 0.43, p = 0.001), with KL grade (r = 0.40, p = 0.001) and weak positive and significant co-relation with sCOMP level (r = 0.24, p = 0.01).

Interpretation and Conclusion: The receiver operative curve (ROC) analysis suggested a “Cut-off” value of sCOMP as 9.06 U/L (Sensitivity 99%; Specificity100%; Accuracy100%) between Control group and Case group with excellent discriminatory power (p = 0.001) but not for various subgroups of disease severity of KOA.

Keywords: Biomarker; Cartilage Oligomeric Matrix Protein (COMP); Cut-Off Value; Osteoarthritis; Knee

References

  1. Lawrence RC., et al. “Estimates of the prevalence of selected arthritic and musculoskeletal diseases in the United States”. The Journal of Rheumatology 16 (1989): 427-441.
  2. Pal CP., et al. “Epidemiology of knee osteoarthritis in India and related factors”. Indian Journal of Orthopaedics 50 (2016): 518-522.
  3. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). WOMAC®1 Index Knee and Hip Osteoarthritis Index (2014).
  4. Altman RD and Gold GE. “Atlas of individual radiographic features in osteoarthritis, (revised)”. Osteoarthritis and CartilageA (2007): A1-56.
  5. CR Davis., et al. “Can biochemical markers serve as surrogates for imaging in Knee osteoarthritis?” Arthritis and Rheumatism12 (2007): 4038-4047.
  6. Landewe R., et al. “Presentation and analysis of radiographic data in clinical trials and observational studies”. Annals of Rheumatic Diseases 4 (2005): iv48-51.
  7. Mazzuca SA., et al. “Development of radiographic changes of osteoarthritis in the “Chingford knee” reflects progression of disease or non-standardised positioning of the joint rather than incident disease”. Annals of Rheumatic Diseases 62 (2003): 1061-1065.
  8. Verma P and Dalal K. “Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: a novel diagnostic and prognostic biomarker”. Journal of Orthopaedic Research 7 (2013): 999-1006.
  9. Andersson ML., et al. “Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis”. BMC Musculoskeletal Disorders1 (2006): 1-8.
  10. Posey KL and Hecht JT. “The role of cartilage oligomeric matrix protein (COMP) in skeletal disease”. Current Drug Targets10 (2008): 869-877.
  11. Tseng S., et al. “Cartilage oligomeric matrix protein (COMP): a biomarker of arthritis”. Biomarker Insights 4 (2009): BMI-S645.
  12. A Awadallah., et al. “Serum level of cartilage oligomeric matrix protein as a screening modality for osteoarthritis among knee joint pain patients”. Minerva Biotecnologica2 (2011): 45-52.
  13. FA Fernandes., et al. “Serum cartilage oligomeric matrix protein (COMP) levels in knee osteoarthritis in a Brazilian population: Clinical and radiological correlation”. Scandinavian Journal of Rheumatology3 (2007): 211-215.
  14. Amy Clark., et al. “Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston County Osteoarthritis Project”. Arthritis and Rheumatology11 (1999): 2356-2364.
  15. Singh S., et al. “Serum Cartilage Oligomeric Matrix Protein: Tool for early diagnosis and grading of severity of primary knee osteoarthritis”. International Journal of Osteology and Orthopedics (IJOO) (2014): 1101.
  16. Singh S., et al. “Serum Cartilage Oligomeric Matrix Protein (COMP) Estimation: A Tool to Assess Efficacy of Treatment in Knee Osteoarthritis”. MOJ Orthopedics and Rheumatology 3 (2014): 1-4.
  17. Jordan JM., et al. “Prevalence of Knee Symptoms and Radiographic and Symptomatic Knee Osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project”. The Journal of Rheumatology1 (2007): 172-180.
  18. M Ishijima., et al. “Distinguishing patients with early stage of radiographic knee osteoarthritis and knee pain”. Osteoarthritis and Cartilage2 (2010): s45-s256.
  19. Tamez-Pena PC., et al. “Early detection of changes in articular cartilage morphology: data from the osteoarthritis initiative”. Osteoarthritis and Cartilage2 (2010): S45-S256.
  20. Mukundan Attur., et al. “Prognostic biomarkers in osteoarthritis”. Current Opinion in Rheumatology 1 (2013): 136-144.
  21. Arunrukthavon P., et al. “Can urinary CTX-II be a biomarker for knee osteoarthritis?” Arthroplasty6 (2020): 1-7.
  22. AD Dragomir., et al. “Osteoarthritis and Cartilage 10 (2002): 687-691.
  23. Hunt ER., et al. “Are serum cartilage degeneration biomarker concentrations accurate representations of the intra-articular environment of knee?” Osteoarthritis and Cartilage 26 (2018): S60-S474.
  24. Vilım V., et al. “Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis”. Osteoarthritis and cartilage9 (2002): 707-713.
  25. Wisłowska M and Jabłońska B. “Serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and knee osteoarthritis”. Clinical Rheumatology 24 (2005): 278-284.
  26. Georgiev T., et al. “Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum biomarkers in knee osteoarthritis: a cross-sectional study”. Rheumatology International 38 (2018): 821-830.
  27. DL Riddle and WA Jiranek. “Knee osteoarthritis radiographic progression and associations with pain and function prior to knee arthroplasty: a multicenter comparative cohort study”. Osteoarthritis and Cartilage 23 (2015): 391e396.
  28. Cubukcu D., et al. “Relationships between Pain, Function and Radiographic Findings in Osteoarthritis of the Knee: A Cross-Sectional Study”. Arthritis (2012): 1-5.
  29. Singh S., et al. “Cartilage oligomeric matrix protein (COMP) and hyaluronic acid (HA): Diagnostic biomarkers of knee osteoarthritis”. MOJ Orthopedics and Rheumatology 2 (2015): 44.
  30. U Shahi., et al. “Role of serum levels of cartilage oligomeric matrix protein in diagnosis and assessment of severity of knee osteoarthritis”. Osteoarthritis and Cartilage 20 (2012): S54-S296.

Citation

Citation: Sudhir Singh., et al. “Efficacy of sCOMP in Diagnosing Knee Osteoarthritis”.Acta Scientific Orthopaedics 6.1 (2023): 130-135.

Copyright

Copyright: © 2023 Sudhir Singh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days

Indexed In



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 20, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US