Efficacy of sCOMP in Diagnosing Knee Osteoarthritis

Sudhir Singh¹*, Chetan Verma² and Lal Shrikant Kaushik²

¹Professor, Department of Orthopaedics, Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India
²Resident, Department of Orthopaedics, Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India

*Corresponding Author: Sudhir Singh, Professor, Department of Orthopaedics, Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India.

Received: November 03, 2022; Published: December 14, 2022

Abstract

Objective: The goal of this study was to establish the utility of serum Cartilage Oligomeric Matrix Protein (sCOMP) as a biomarker for differentiating between disease severity grades of knee osteoarthritis (KOA).

Material and Method: Patients of osteoarthritis of knee were included as Cases (100 subjects) and normal adults were taken as Controls (50 subjects). Clinical, radiological and biochemical assessment was done by WOMAC score, knee radiograph and blood sample for sCOMP respectively.

Results: Results show WOMAC Score was significantly higher in cases (49.97 ± 17.98) than in Controls (11.24 ± 06.07) (p < 0.001). Mean sCOMP level was significantly higher in Case group than in Control group (17.38 ± 4.99 U/L vs 1.16 ± 0.39 U/L; p = 0.001). sCOMP increases with increasing K-L grades except in grade III. In Case group sCOMP was 14.60 ± 6.47 U/L in K-L grade I; as 17.47 ± 4.99 U/L in K-L grade II; as 17.25 ± 4.63 U/L in K-L grade III and as 19.77 ± 4.65 U/L in K-L grade IV. One-way ANOVA of K-L Grade with sCOMP (F = 1.55, p = 0.02) and with WOMAC score (F = 20.18, p = 0.001) show significant association. Pearson Correlation and coefficient (r) value show that Age has moderate positive and significant co-relation with WOMAC Score (r = 0.43, p = 0.001), with KL grade (r = 0.40, p = 0.001) and weak positive and significant co-relation with sCOMP level (r = 0.24, p = 0.01).

Interpretation and Conclusion: The receiver operative curve (ROC) analysis suggested a “Cut-off” value of sCOMP as 9.06 U/L (Sensitivity 99%; Specificity100%; Accuracy100%) between Control group and Case group with excellent discriminatory power (p = 0.001) but not for various subgroups of disease severity of KOA.

Keywords: Biomarker; Cartilage Oligomeric Matrix Protein (COMP); Cut-Off Value; Osteoarthritis; Knee

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Citation

Citation: Sudhir Singh., et al. “Efficacy of sCOMP in Diagnosing Knee Osteoarthritis”.Acta Scientific Orthopaedics 6.1 (2023): 130-135.

Copyright

Copyright: © 2023 Sudhir Singh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.