Hassan Mohammed Hassan Elbahri¹, Osman Mohamed Mohamed Ahmed², Mohammed Mubarak Mohammed Ahmed³, Dafaalla Abdelmoneim Dafaalla Salih⁴ and Hozifa Mohammed Ali Abd-Elmaged^5*

¹Associated Professor of Orthopedic Oncology, Department of Orthopedic International University of Africa - Khartoum, Sudan
²MD Orthopedics and Trauma, Sudan
³MD Orthopedics and Trauma, Ibrahim Malik Teaching Hospital, Sudan
⁴Medical Student at Al-Zaiem Al-Azhari University, Khartoum, Sudan
⁵Assistant Professor of Orthopedic, Department of Orthopedic Al-Zaiem Al-Azhari University- Khartoum, Sudan

*Corresponding Author: Hassan Mohammed Hassan Elbahri, Associated Professor of Orthopedic Oncology, Department of Orthopedic International University of Africa - Khartoum, Sudan

Received: August 29, 2022; Published: December 06, 2022

Abstract

Background: A malignant bone tumour is a neoplastic growth of tissue in bone which can be benign or malignant. Amputation is the removal part or all of a limb. When used to treat cancer, amputation removes the limb part with the tumour, some healthy tissue above it, and everything below it. The prognosis depends on the type of tumour. The outcome is expected to be good for people with benign tumours, although some types of benign tumours may eventually become malignant.

Methods: Observational descriptive cross-sectional hospital-based study was conducted in Ibrahim Malik Teaching Hospital in Khartoum State in the period from January 2018 to September 2018. Data was collected using a datasheet. Data entered and analyzed using SPSS version 25.0.

Results: This study covered 50 study participants, most of them (96%) were less than 40 years of age. Our study found that only (16%) of the study participants were fully aware of their disease while (40%) were not aware at all. Furthermore, there was a delay between the presentation and starting the treatment among most of them (90%) while (82%) had tried other traditional or non-formal methods of treatment. Concerning the type of tumour, most of the study participants (84%) were diagnosed with osteosarcoma, while a small proportion of them was diagnosed with Chondrosarcoma (6%), Ewing sarcoma (6%), and Admantinoma among only (4%). The study found that the total number of patients with primary bone sarcoma were 65 patient from January to June 2018(hospital records) so the incidence of amputation at that time was 76%. Regarding the management applied, all study participants were amputated, of which (56%) had chemotherapy and (12%) had radiotherapy. The analysis found that there is a significant association between the level of education and the delayed presentation (pvalue < 0/001).

Conclusion and Recommendation:A high awareness of malignant bone tumours are essential to avoid diagnostic delays. Some might even be dangerous.

Keywords: Malignant Bone; Amputation; Chondrosarcoma; Ewing sarcom; Admantinoma

References

1. Durfee RA., et al. “Review of Osteosarcoma and Current Management”. Rheumatology and Therapy2 (2016): 221-243.
2. Garcia RA., et al. “Benign bone tumours-recent developments”. Seminars in Diagnostic Pathology 1 (2011): 73-85.
3. Rajani R and Gibbs CP. “Treatment of Bone Tumors”. Surgical Pathology Clinics 1 (2012): 301-318.
4. Moore TM and Harvey JP. “The Management of Benign Bone Lesions”. Western Journal of Medicine. Revised2 (2011): 92-98.
5. Eyre R., et al. “The epidemiology of bone cancer in 0 - 39-year-olds in northern England, 1981 - 2002”. BMC Cancer 10 (2010): 357.
6. Ajibade A., et al. “Indications and Complications of Major Limb Amputations in Kano, Nigeria”. Ghana Medical Journal4 (2013): 185-188.
7. Saeed IE., et al. “Cancer incidence in Khartoum, Sudan: first results from the Cancer Registry, 2009-2010”. Cancer Medicine 4 (2014): 1075-1084.
8. Bertoni F and Bacchini P. “Classification of bone tumours”. European Journal of Radiology 1 (1998): S74-76.
9. Zile Singh Kundu. “Classification, imaging, biopsy and staging of osteosarcoma”. Indian Journal of Orthopaedics 3 (2014): 238-246.
10. Clasper J and Ramasamy A. “Amputations”. British Journal of Pain 2 (2013): 67-73.
11. Puhaindran ME., et al. “Major upper-limb amputations for malignant tumours”. Journal of Hand Surgery American 6 (2012): 1235-1241.
12. Noor S., et al. “Limb versus life: the outcomes of osteosarcoma in Cambodia”. International Orthopaedics 3 (2013): 579-585.
13. Li X., et al. “A comparative study between limb salvage and amputation for treating osteosarcoma”. Journal of Bone Oncology 1 (2016): 15-21.
14. Postma A1., et al. “Quality of life in bone tumor patients comparing limb salvage and amputation of the lower extremity”. Journal of Surgical Oncology 1 (2016): 47-51.
15. Robert RS., et al. “Psychosocial and Functional Outcomes in Long-Term Survivors of Osteosarcoma: A Comparison of Limb-Salvage Surgery and Amputation”. Pediatric Blood and Cancer 7 (2010): 990-999.
16. Wafa H and Grimer RJ. “Surgical options and outcomes in bone sarcoma”. Expert Review of Anticancer Therapy2 (2006): 239-248.
17. Kamal AF., et al. “Clinical Outcome and Survival of Osteosarcoma Patients in Cipto Mangunkusumo Hospital: Limb Salvage Surgery versus Amputation”. Acta Medica Indonesiana 3 (2016): 175-183.
18. Van Egmond-van Dam JC., et al. “Functional outcome after surgery in patients with bone sarcoma around the knee; results from a long-term prospective study”. Journal of Surgical Oncology 8 (2017): 1028-1032.
19. Puhaindran ME., et al. “Major upper-limb amputations for malignant tumours”. Journal of Hand Surgery American 6 (2012): 1235.
20. Postma A., et al. “Quality of life in bone tumor patients comparing limb salvage and amputation of the lower extremity”. Journal of Surgical Oncology 1 (1992): 47-51.
21. Anract P. “[Surgical management of primary bone cancer]”. Bulletin de l'Académie Nationale de Médecine 1 (2009): 107-126.
22. Parsons CM., et al. “The role of radical amputations for extremity tumours: a single-institution experience and review of the literature”. Journal of Surgical Oncology 2 (2011): 149-155.

Citation

Citation: Hassan Mohammed Hassan Elbahri., et al. “Incidence of Malignant Bone Tumors and Short-Term Functional Outcome of Amputation”.Acta Scientific Orthopaedics 6.1 (2023): 52-58.

Copyright

Copyright: © 2023 Hassan Mohammed Hassan Elbahri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.