Acta Scientific Orthopaedics (ISSN: 2581-8635)

Review Article Volume 5 Issue 12

How Common are Fungal Fracture Related Infections? A Literature Review of Fungal Fracture Related Infections

Dhanasekaraprabu Balasubramanian*, Alexis-Dimitris Iliadis, Alexandros Vris and Nima Heidari

Bone Infection and Limb reconstruction Service, Royal London Hospital, Barts Health NHS, UK

*Corresponding Author: Dhanasekaraprabu Balasubramanian, Bone Infection and Limb reconstruction Service, Royal London Hospital, Barts Health NHS, UK.

Received: August 22, 2022; Published: November 08, 2022

Abstract

Infections following Fracture fixation is one of the dreaded complications in the setting of polytrauma. While bacteria seem to be the predominant pathogen in most of the Fractures related infections (FRI), Fracture related infections caused by fungus are quite severe and sometimes missed as they are not common. Also, the published literature on Fungal FRI’s is few when compared to published reports of fungal prosthetic joint infection. Fracture related infections in the setting of polytrauma can be bacterial, fungal, or mixed. They pose several diagnostic and surgical challenges, but the principles of treatment and reconstruction include thorough debridement and appropriate antimicrobial therapy.

Keywords: Fractures related infections, Polytrauma

References

  1. Galvain T., et al. “The economic burden of infections following intramedullary nailing for a tibial shaft fracture in England”. BMJ Open8 (2020): 1-11.
  2. Metsemakers WJ., et al. “Prevention of fracture-related infection: a multidisciplinary care package”. International Orthopaedics12 (2017): 2457-2469.
  3. Trampuz A and Zimmerli W. “Diagnosis and treatment of infections associated with fracture-fixation devices”. Injury2 (2006): 59-66.
  4. Govaert GAM., et al. “Diagnosing Fracture-Related Infection: Current Concepts and Recommendations”. Journal of Orthopaedic Trauma1 (2020): 8-17.
  5. Metsemakers WJ., et al. “Definition of infection after fracture fixation: A systematic review of randomized controlled trials to evaluate current practice”. Injury3 (2018): 497-504.
  6. Parvizi J., et al. “The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria”. Journal of Arthroplasty5 (2018): 1309-1314.e2.
  7. Metsemakers WJ., et al. “Fracture-related infection: A consensus on definition from an international expert group”. Injury 3 (2018): 505-510.
  8. Gross CE., et al. “Fungal Periprosthetic Joint Infection: A Review of Demographics and Management”. The Journal of Arthroplasty5 (2021): 1758-1764.
  9. BH H., et al. “Fungal peri-prosthetic joint infection after primary total knee replacement”. The Journal of Bone and Joint Surgery British5 (2012): 656-659.
  10. JT B., et al. “Fungal osteomyelitis and septic arthritis. The Journal of the American Academy of Orthopaedic Surgeons 22.6 (2014): 390-401.
  11. AC W., et al. “Combat trauma-associated invasive fungal wound infections: epidemiology and clinical classification”. Epidemiology and Infection1 (2015): 214-224.
  12. Kronen R., et al. “Invasive Fungal Infections Secondary to Traumatic Injury”. International Journal of Infectious Diseases 62 (2017): 102-111.
  13. J Van Den K., et al. “Diagnostic accuracy of serum inflammatory markers in late fracture-related infection: a systematic review and meta-analysis”. The Bone and Joint Journal 100-B.12 (2018): 1542-1550.
  14. K A., et al. “Microbiological, clinical, and surgical features of fungal prosthetic joint infections: a multi-institutional experience”. The Journal of Bone and Joint Surgery American6 (2009): 142-149.
  15. HK Y., et al. “A Review of the Literature on Culture-Negative Periprosthetic Joint Infection: Epidemiology, Diagnosis and Treatment”. Knee Surgery and Related Research3 (2017): 155-164.
  16. O J., et al. “Fungal periprosthetic joint infection in total knee arthroplasty: a systematic review”. Orthopedic Reviews1 (2015).
  17. M T., et al. “Can next generation sequencing play a role in detecting pathogens in synovial fluid?” The Bone and Joint Journal 100-B.2 (2018): 127-133.
  18. Pulcini C., et al. “Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach”. Clinical Microbiology and Infection1 (2019): 20-25.
  19. Ostermann PAW., et al. “Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases”. Journal of Bone and Joint Surgery - Series B1 (1995): 93-97.
  20. Lehner B., et al. “First experiences with negative pressure wound therapy and instillation in the treatment of infected orthopaedic implants: a clinical observational study”. International Orthopaedics 9 (2011): 1415.
  21. Morgenstern M., et al. “The effect of local antibiotic prophylaxis when treating open limb fractures: A systematic review and meta-analysis”. Bone and Joint Research7 (2018): 447-456.
  22. Anagnostakos K., et al. “Fungal Periprosthetic Hip and Knee Joint Infections: Clinical Experience With a 2-Stage Treatment Protocol”. The Journal of Arthroplasty2 (2012): 293-298.
  23. Ueng , et al. “What Is the Success of Treatment of Hip and Knee Candidal Periprosthetic Joint Infection?” Clinical Orthopaedics and Related Research 471.9 (2013): 3002.
  24. Cunningham B., et al. “Liposomal Formulation Increases Local Delivery of Amphotericin from Bone Cement: A Pilot Study”. Clinical Orthopaedics and Related Research 470 (10 (2012): 2671.
  25. Rouse MS., et al. “Are Anidulafungin or Voriconazole Released from Polymethylmethacrylate In Vitro?” Clinical Orthopaedics and Related Research5 (2018): 1466.
  26. Schoof B., et al. “Fungal Periprosthetic Joint Infection of the Hip: A Systematic Review”. Orthopedic Reviews1 (2015): 18-22.
  27. Cobo F., et al. “Candida Prosthetic Joint Infection. A Review of Treatment Methods”. Journal of Bone and Joint Infection2 (2017): 114.
  28. Kuiper JW., et al. “2-stage revision recommended for treatment of fungal hip and knee prosthetic joint infections: An analysis of 164 patients, 156 from the literature and 8 own cases”. Acta Orthopaedica 6 (2013): 517.

Citation

Citation: Jasrah Javed. “Identification of Individual Risk Factors for Development of Work-Related Non-Specific Neck Pain among Office Workers". Acta Scientific Orthopaedics 5.12 (2022): 46-49.

Copyright

Copyright: © 2022 Jasrah Javed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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