Acta Scientific Orthopaedics (ISSN: 2581-8635)

Editorial Volume 5 Issue 12

Vitamin D Supplementation: Still a Paradox!

Archisha Marya1 and Kirti Mohan Marya2*

1School of Medicine, Faculty of Health and Life Sciences, University of Liverpool, United Kingdom
2Group Medical Director and Chief Orthopaedic Surgeon, Life Healthcare Group, Dubai, United Arab Emirates

*Corresponding Author: Kirti Mohan Marya, Group Medical Director and Chief Orthopaedic Surgeon, Life Healthcare Group, Dubai, United Arab Emirates.

Received: October 20, 2022; Published: November 01, 2022


The classic work of Francis Glisson, a Cambridge physician, titled “De Rachitide” was published in Latin in 1650 and is still considered a treatise on rickets. Glisson was of the opinion that rickets was neither transmissible nor hereditary. His hypothesis regarding the association of age to the onset of rickets has remained time-tested [1].


  1. Dunn PM. “Francis Glisson (1597-1677) and the “discovery” of rickets”. Archives of Disease in Childhood. Fetal and Neonatal Edition 78 (1998): F154-F155.
  2. Chesney RW. “Theobald Palm and his remarkable observation: How the sunshine vitamin came to be recognized”. Nutrients 4 (2012): 42-51.
  3. DeLuca HF. “History of the discovery of vitamin D and its active metabolites”. BoneKEy Reports 3 (2014): 479-485.
  4. Heckmatt JZ., et al. “Plasma 25-hydroxyvitamin D in pregnant Asian women and their babies”. Lancet 2 (1979): 546-549.
  5. Cockburn F., et al. “Maternal vitamin D intake and mineral metabolism in mothers and their newborn infants”. The British Medical Journal 281 (1980): 11-14.
  6. Brooke OG., et al. “Vitamin D supplements in pregnant Asian women: effect on calcium status and fetal growth”. The British Medical Journal 280 (1980): 751-754.
  7. Goswami R., et al. “Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi”. The American Journal of Clinical Nutrition 72 (2000): 472-475.
  8. Aparna P., et al. “Vitamin D deficiency in India”. Journal of Family Medicine and Primary Care 7 (2018): 324-330.
  9. Riaz H., et al. “Prevalence of vitamin D deficiency in Pakistan and implications for the future”. Expert Review of Clinical Pharmacology 9 (2016): 329-338.
  10. Islam AK., et al. “Vitamin D status in Bangladeshi subjects: a laboratory-based study”. BIRDEM Medical Journal 9 (2019): 202-206.
  11. Nimri LF. “Vitamin D status of female UAE college students and associated risk factors”. Journal of Public Health. Oxford 40 (2018): e284-e290.
  12. Mogire RM., et al. “Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis”. The Lancet Global Health 8 (2019): E134-E142.
  13. Bassuk SS., et al. “VITAL Research Group (2020). The VITamin D and OmegA-3 TriaL (VITAL): Do Results Differ by Sex or Race/Ethnicity?” American Journal of Lifestyle Medicine 4 (2020): 372-391.
  14. Chiu KC., et al. “Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction”. The American Journal of Clinical Nutrition 79 (2004): 820-825.
  15. Luong K., et al. “The role of vitamin D in protecting type 1 diabetes mellitus”. Diabetes/Metabolism Research and Reviews 21 (2005): 338-346.
  16. Pittas AG., et al. “The role of vitamin D and calcium in type 2 diabetes: a systematic review and meta-analysis”. The Journal of Clinical Endocrinology and Metabolism 92 (2007): 2017-2029.
  17. Krause R., et al. “Ultraviolet B and blood pressure”. Lancet 352 (1998): 709-710.
  18. Kostoglou-Athanassiou F., et al. “Vitamin D and rheumatoid arthritis”. Therapeutic Advances in Endocrinology and Metabolism 3 (2012): 181-187.
  19. Munger KL., et al. “Vitamin D intake and incidence of multiple sclerosis”. Neurology 62 (2004): 60- 65.
  20. Youssef SA., et al. “Antimicrobial implications of vitamin D”. Dermato-Endocrinology 3 (2011): 220-229.
  21. MacLaughlin JA., et al. “Special character of sunlight modulates the photosynthesis of provitamin D3 and its photoisomers in human skin”. Science 216 (1982): 1001-1003.
  22. Holick MF., et al. “Factors that influence the cutaneous photosynthesis of previtamin D3”. Science 211 (1981): 590-593.
  23. Engelsen O. “The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status”. Nutrients 2 (2010): 482-495.
  24. Marya KM and Marya A. “Vitamin D deficiency: supplementation or test and treat?” International Journal of Clinical Rheumatology4 (2021): 127-128.
  25. Stewart BW. “Priorities for cancer prevention: lifestyle choices versus unavoidable exposures”. Lancet Oncology3 (2012): e126-133.


Citation: Archisha Marya and Kirti Mohan Marya. “Vitamin D Supplementation: Still a Paradox!". Acta Scientific Orthopaedics 5.12 (2022): 01-03.


Copyright: © 2022 Archisha Marya and Kirti Mohan Marya. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate33%
Acceptance to publication20-30 days

Indexed In

News and Events

Contact US