Acta Scientific Orthopaedics (ISSN: 2581-8635)

Case Report Volume 5 Issue 8

Case Report: Limb Salvage with the Use of an Absorbable Antibiotic Cement Spacer

Chandana Halaharvi*

Private Practice in Houston, TX, USA

*Corresponding Author: Chandana Halaharvi, Private Practice in Houston, TX, USA.

Received: June 10, 2022; Published: July 15, 2022

It is well established in the literature that systemic antibiotics are limited in treating diabetic foot infections. Seabrook studied the antibiotic level in a diabetic foot at the time of sepsis. He found that only 12/26 patients showed the presence of antibiotics in the surrounding muscle tissue of a septic diabetic patient when the antibiotic was administered an hour before surgery. Only six of the 26 patients were found to have therapeutic antibiotic levels within the foot. Due to the low level of systemic antibiotics found within the pedal bone and soft tissue, local antibiotics are a great addition to treating pedal osteomyelitis.

Polymethyl methacrylate (PMMA) antibiotic beads and cement have been widely used and accepted. However, there are a few issues with using non-absorbable antibiotic cement, including the need for antibiotic bead removal, inconsistent rate of drug elution and need for secondary operation for antibiotic bead/spacer removal, and high inflammatory reaction.

Keywords:Salvage; Cement Spacer; Absorbable Antibiotic

References

  1. Seabrook G., et al. “Comparison of serum and tissue antibiotic levels in diabetes-related foot infections”. Surgery4 (1991): 671-677.
  2. Delury C., et al. “Determining the Efficacy of Antibiotic-loaded Calcium Sulfate Beads against Pre-Formed Biofilms: An In Vitro Study, in ASM Microbe”. 2019: San Francisco, USA (2019).
  3. Somasundaram K., et al. “Proximal humeral fractures: the role of calcium sulphate augmentation and extended deltoid splitting approach in internal fixation using locking plates”. Injury4 (2013): 481-487.
  4. Lazarou SA., et al. “Correction of alveolar cleft with calcium-based bone substitutes”. Journal of Craniofacial Surgery 3 (2011): 854-857.
  5. Lei D., et al. “Treatment of Distal Radius Bone Defects with Injectable Calcium Sulphate Cement”. in Bone Grafting, A. Zorzi, Editor, InTech (2012): 125-134.
  6. Udomkusonsri P., et al. “Elution profiles of cefazolin from PMMA and calcium sulfate beads prepared from commercial cefazolin formulations”. The Journal of Veterinary Medical Science 74 (2012): 301-305.
  7. Ferguson JY., et al. “The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis: a series of 195 cases”. The Bone and Joint Journal 96-B (2014): 829-836.

Citation

Citation: Chandana Halaharvi. “Case Report: Limb Salvage with the Use of an Absorbable Antibiotic Cement Spacer". Acta Scientific Orthopaedics 5.8 (2022): 98-100.

Copyright

Copyright: © 2022 Chandana Halaharvi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days

Indexed In



News and Events


Contact US