Abdelsalam Mohamed Ahmed¹, Mohamed Kharief², Ayoub Mustafa Omar Ali³, Musaab Mohamed Abdallah⁴* and Mohamed Alkhatem⁵

¹MBBS MD MSc FRCP, Associate Professor of Internal Medicine, Department of Internal Medicine, Faculty of Medicine and Health Sciences (OIU), Sudan
²Registrar of Internal Medicine, Sudan
³MBBS, MD Internal Medicine, Sudan
⁴MD Orthopaedics Associate department Karary University, Sudan
⁵MBBS, MD Orthopaedics, Department Karary University, Sudan

*Corresponding Author: MBBS, MD Orthopaedics, Associate Professor Karary University, Sudan.

Received: May 11, 2022; Published: July 15, 2022

One of the commonest modes of detection of hepatitis-B virus (HBV) infection is incidental detection. Incidentally detected asymptomatic HBsAg (IDAHS) positive patients represent a heterogeneous group with variable serological and clinical profile. The aim is to study the viral activity of IDAHS positive patients.

Keywords:Asymptomatic HBSAG; Positive Patients; Viral Activity

References

1. Abbas Z and Siddiqui AR. “Management of hepatitis B in developing countries”. World Journal of Hepatology 12 (2011): 292.
2. Lok ASF and McMahon BJ. “Chronic hepatitis B”. Hepatology 2 (2007): 507-539.
3. Mudawi H. “Epidemiology of viral hepatitis in Sudan”. Clinical and Experimental Gastroenterology 1 (2008): 9.
4. Shiha G., et al. “Characterization of incidentally detected asymptomatic hepatitis B positive subjects in Egypt”. Bangladesh Liver Journal1 (2009): 20-27.
5. Dixit VK and Jena SK. “Incidentally detected asymptomatic HBsAg positive subjects”. Hepatitis B - Annual 1 (2008): 95.
6. Hsu YS., et al. “Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B”. Hepatology6 (2002): 1522-1527.
7. Bortolotti F., et al. “Outcome of chronic hepatitis B in Caucasian children during a 20-year observation period”. Journal of Hepatology 2 (1998): 184-190.
8. Kreutz C. “Molecular, immunological and clinical properties of mutated hepatitis B viruses”. Journal of Cellular and Molecular Medicine 1 (2002): 113.
9. Ter Borg F., et al. “Relation between laboratory test results and histological hepatitis activity in individuals positive for hepatitis B surface antigen and antibodies to hepatitis B e antigen”. Lancet (London, England) 351 (9120): 1914-1918.
10. Liaw YF. “HBeAg seroconversion as an important end point in the treatment of chronic hepatitis B”. Hepatology International 3 (2009): 425.
11. Badawi MM., et al. “A Diagnostic Laboratory-Based Study on Frequency and Distribution of Viral Hepatitis B and C Among Sudanese”. The Open Virology Journal 1 (2017): 98.
12. Choudhuri G., et al. “Potential Implications of Detecting HBsAg in Asymptomatic People in an Endemic Community Through Medical Camps”. Journal of Clinical and Experimental Hepatology 1 (2019): 43-49.
13. Arora D., et al. “Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana”. Indian Journal of Pathology and Microbiology 2 (2010): 308-309.
14. Unnikrishnan B., et al. “Profile of blood donors and reasons for deferral in coastal South India”. Australasian Medical Journal 7 (2011): 379-385.
15. Chen C-J., et al. “Hepatocellular carcinoma occurred in a Hepatitis B carrier clinic cohort during a mean follow up of 10 years”. Hepatoma Research 5 (2019): 25.
16. Khokhar N and Gill ML. “Serological profile of incidentally detected asymptomatic HBsAg positive subjects (IDAHS)”. Journal of College of Physicians and Surgeons Pakistan 4 (2004): 208-210.
17. Kashif M., et al. “Serological markers of hepatitis B infection in incidentally Incidentally Detected HBsAg Positive Patients”. Proceedings of Shaikh Zayed Postgraduate Medical Institute 0 (2006): 93-97.
18. Chu CM and Liaw YF. “HBsAg seroclearance in asymptomatic carriers of high endemic areas: Appreciably high rates during a long-term follow-up”. Hepatology 5 (2007): 1187-1192.
19. Chu CJ., et al. “Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C”. Gastroenterology 7 (2002): 1756-1762.
20. Chandra R., et al. “Profile of asymptomatic chronic HBV infection in India”. Indian Journal of Medical Research 6 (2002): 50-57.
21. Yousif M., et al. “Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan”. BMC Infectious Diseases 1 (2013): 1-11.
22. Girotra M and Arora A. “IDAHS (Incidentally Detected Asymptomatic HbsAg-positive Subjects): Clinical and Serological Overview”. The American Journal of Gastroenterology 5 (2010): S95.
23. Martín-Vílchez S., et al. “Effects of hepatitis B virus X protein on chronic hepatitis B pathophysiology”. Medicina Clínica (Barc)11 (2012): 508-513.
24.  

Citation

Citation: Musaab Mohamed Abdallah., et al. “Viral Activity Among Incidentally Detected Asymptomatic HBSAG Positive Patients in Khartoum State". Acta Scientific Orthopaedics 5.8 (2022): 71-77.

Copyright

Copyright: © 2022 Musaab Mohamed Abdallah., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.