Vitamin K and Osteoarthritis Associated Observations: “What’s New” in 2022
Ray Marks*
Single Incision Department of Health and Behavior Studies, Teachers College, Columbia University, New York, United States
*Corresponding Author: Ray Marks, Department of Health and Behavior Studies, Teachers College, Columbia University, New York, United States.
Received:
June 30, 2022; Published: July 12, 2022
Osteoarthritis, the most common joint disease experienced by many older adults and one that is increasing as societies age remains largely incurable and highly disabling. As such, and in light of the failure of most palliative pharmacologic strategies to date to reverse or mitigate this painful condition, it appears all avenues of potential progress added to those already being explored may yet prove fruitful. Based on emerging and quite promising data outlining a possible link between aspects of osteoarthritis joint damage and vitamin K serum deficits, this mini-review elected to examine the most current data in regard to whether: 1) Vitamin K, an important dietary compound is being shown to be a potentially valuable health determinant whose presence might influence the onset and progression of osteoarthritis through direct as well as indirect pathways, and 2) any evidence pointing to its possible supplementation as being desirable in this regard if indicated. Based on the bulk of available data housed in PUBMED as of June 25, 2022, it is concluded that a mediating or moderating role for vitamin K in the realm of osteoarthritis cannot be ignored. Future efforts to advance this line of inquiry from multiple perspectives may hence prove highly fruitful in efforts to prevent or reduce osteoarthritis disability and its immense personal and socioeconomic costs.
Keywords: Aging; Bone; Cartilage; Osteoarthritis; Pathology; Prevention; Vitamin K
References
- Harshman Stephanie G and M Kyla Shea. “The role of vitamin K in chronic aging diseases: inflammation, cardiovascular disease, and osteoarthritis”. Current Nutrition Reports2 (2016): 90-98.
- Long Huibin., et al. "Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the Global Burden of Disease Study 2019." Arthritis and Rheumatology (2022).
- Zheng Xiao-Yan., et al. "Role of fat-soluble vitamins in osteoarthritis management”. Journal of Clinical Rheumatology3 (2018): 132-137.
- Loeser Richard F., et al. "Vitamin K and osteoarthritis: is there a link?”. Annals of the Rheumatic Diseases5 (2021): 547-549.
- Abd-El Wahab S., et al. "Potential role of vitamin K in radiological progression of early knee osteoarthritis patients”. The Egyptian Rheumatologist3 (2016): 217-223.
- Azuma Kotaro and Satoshi Inoue. “Multiple modes of vitamin k actions in aging-related musculoskeletal disorders”. International Journal of Molecular Sciences11 (2019): 2844.
- Hamidi Maryam S and Angela M Cheung. “Vitamin K and musculoskeletal health in postmenopausal women”. Molecular Nutrition and Food Research8 (2014): 1647-1657.
- Misra Devyani., et al. "Vitamin K deficiency is associated with incident knee osteoarthritis”. The American Journal of Medicine3 (2013): 243-248.
- Oka Hiroyuki., et al. "Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study”. Journal of Orthopaedic Science6 (2009): 687-692.
- Thomas Sally., et al. "What is the evidence for a role for diet and nutrition in osteoarthritis?” Rheumatology4 (2018): iv61-iv74.
- Bordoloi Jijnasa., et al. "Implication of a novel vitamin K dependent protein, GRP/Ucma in the pathophysiological conditions associated with vascular and soft tissue calcification, osteoarthritis, inflammation, and carcinoma”. International Journal of Biological Macromolecules 113 (2018): 309-316.
- Simes Dina C., et al. "Vitamin K as a diet supplement with Impact in Human Health: current evidence in age-related diseases”. Nutrients1 (2020): 138.
- Rafael Marta S., et al. "Insights into the association of GLA-rich protein and osteoarthritis, novel splice variants and γ-carboxylation status”. Molecular Nutrition and Food Research8 (2014): 1636-1646.
- Chin Kok-Yong., et al. "Relationship amongst Vitamin K status, vitamin K antagonist use and osteoarthritis: a review”. Drugs and Aging (2022).
- Bolzetta Francesco., et al. "The relationship between dietary vitamin K and depressive symptoms in late adulthood: a cross-sectional analysis from a large cohort study”. Nutrients4 (2019): 787.
- Shea MK., et al. "The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study”. Osteoarthritis and Cartilage3 (2015): 370-378.
- Van Ballegooijen Adriana J., et al. "Vitamin K status and physical decline in older adults-The Longitudinal Aging Study Amsterdam”. Maturitas 113 (2018): 73-79.
- Schwalfenberg and Gerry Kurt. “Vitamins K1 and K2: the emerging group of vitamins required for human health”. Journal of Nutrition and Metabolism 2017 (2017): 6254836.
- Naito Kiyohito., et al. "Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis”. International Journal of Molecular Medicine 29.5 (2012): 756-760.
- Shioi Atsushi., et al. "The inhibitory roles of vitamin K in progression of vascular calcification”. Nutrients2 (2020): 583.
- Hale JE., et al. "Carboxyl-terminal proteolytic processing of matrix GLA protein”. The Journal of Biological Chemistry31 (1991): 21145-21149.
- Ishii Yoshinori., et al. "Distribution of vitamin K2 in subchondral bone in osteoarthritic knee joints”. Knee Surgery, Sports Traumatology, Arthroscopy8 (2013): 1813-1818.
- Xiao Huiyu., et al. "Role of emerging vitamin K‑dependent proteins: growth arrest‑specific protein 6, GLA‑rich protein and periostin”. International Journal of Molecular Medicine3 (2021): 1-1.
- Neogi Tuhina., et al. "Low vitamin K status is associated with osteoarthritis in the hand and knee”. Arthritis and Rheumatism4 (2006): 1255-1261.
- Shea M Kyla., et al. "Vitamin K status and mobility limitation and disability in older adults: The Health, Aging, and Body Composition Study”. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences4 (2020): 792-797.
- De Boer Cindy G., et al. "Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis”. Annals of the Rheumatic Diseases5 (2021): 598-604.
- Wallin R., et al. "Biosynthesis of the vitamin K-dependent matrix GLA protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes”. Osteoarthritis and Cartilage8 (2010): 1096-1103.
- Houtman E., et al. "Characterization of dynamic changes in Matrix GLA Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin”. Osteoarthritis and Cartilage8 (2021): 1193-1202.
- Zhao Sizheng Steven., et al. "Genetically predicted vitamin K levels and risk of osteoarthritis: Mendelian randomization study”. Seminars in Arthritis and Rheumatism 55 (2022): 152030.
- Den Hollander Wouter., et al. "Genome-wide association and functional studies identify a role for matrix GLA protein in osteoarthritis of the hand”. Annals of the Rheumatic Diseases12 (2017): 2046-2053.
- Stock Michael and Georg Schett. “Vitamin K-dependent proteins in skeletal development and disease”. International Journal of Molecular Sciences17 (2021): 9328.
- Chin Kok-Yong. “The relationship between vitamin K and osteoarthritis: a review of current evidence”. Nutrients5 (2020): 1208.
- Wen Lianpu., et al. "Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review)”. Molecular Medicine Reports1 (2018): 3-15.
- Liao Zetao., et al. "Associations between dietary intake of vitamin K and changes in symptomatic and structural changes in patients with knee osteoarthritis”. Arthritis Care and Research (2021).
- Okuyan Hamza Malik., et al. "Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis”. International Journal of Rheumatic Diseases10 (2019): 1884-1890.
- Okuyan Hamza Malik., et al. "In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model”. Canadian Journal of Physiology and Pharmacology11 (2020): 763-770.
- Capozzi Anna., et al. "Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health”. Maturitas140 (2020): 55-63.
- Kubovic Milan., et al. "Analgetic property of vitamin K”. Proceedings of the Society for Experimental Biology and Medicine3 (1955): 660-662.
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