Acta Scientific Orthopaedics (ISSN: 2581-8635)

Clilnical Case Report Volume 5 Issue 6

Nasal Septum Metastasis of Renal Cell Carcinoma 7 Years After Nephrectomy: A Case Report

Vladan Milutinovic1,2, Snezana Sankovic-Babic1,2, Zorana Radin1, Rade Kosanovic1,2 and Ivan Baljosevic3*

1Ear, Nose and Throat Clinic, Clinical Hospital Center Zvezdara, Belgrade, Serbia
2Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia
3Mother and Child Health Institute, Faculty of Dentistry, Pancevo, Serbia

*Corresponding Author: Ivan Baljosevic, Mother and Child Health Institute, Faculty of Dentistry, Pancevo, Serbia.

Received: April 26, 2022; Published: May 11, 2022

Abstract

Introduction: Malignant tumors of the nose and paranasal cavities are rare tumors that account for less than 1% of body malignancies and 3-5% of malignancies of the head and neck. Metastatic tumors in the sinonasal region are extremely rare, but renal cell carcinoma (RCC) metastases are the most common in this region. The aim of this study was to present the clinical features, diagnostic and therapeutic options in this rare metastatic tumor growth of the nose, and the significance of the postoperative follow-up period of these patients.Case outline: A 70-year-old male patient was examined due to difficulty breathing in the nose on the left side with occasional bleeding. Clinical examination revealed a papillomatous growth in the left vestibule of the nose attached to the nasal septum. The presence of clear cell tumor proliferation was determined pathohistological and further immunohistochemical analysis was advised. Patient had nephrectomy performed due to adenocarcinoma of the kidney in 2011., after which he was not regularly followed. Further diagnostic procedures revealed a metastasis of renal cell carcinoma. After the surgical treatment was completed, the patient was treated with chemotherapy. Conclusion: In patients with observed unilateral growth in the sinonasal region, which occasionally bleeds and leads to nasal obstruction, with the obtained anamnestic data that their RCC has been previously confirmed or treated, it is important to think about metastatic tumor by differential diagnosis. In most patients, early detection of metastasis provides the possibility of surgical treatment and a more favorable response to systemic therapy.  
Keywords: Renal Cell Carcinoma; Metastasis; Nasal Septum; Epistaxis

References

  1. El-Gerby KM and El-Anwar MW. “Differentiating Benign from Malignant Sinonasal Lesions: Feasibility of Diffusion Weighted MRI”. International Archives of Otorhinolaryngology 4 (2017): 358-365.
  2. Peck BW., et al. “Rates and Locations of Regional Metastases in Sinonasal Malignancies: The Mayo Clinic Experience”. Journal of Neurological Surgery Part B: Skull Base 3 (2018): 282-288.
  3. Dutta R., et al. “Sinonasal malignancies: A population-based analysis of site-specific incidence and survival”. Laryngoscope 11 (2015): 2491-2497.
  4. Khurayzi T and Alshahrani “Metastatic paranasal sinuses adenocarcinoma from breast carcinoma, a rare event: a case report”. International Journal of Otorhinolaryngology and Head and Neck Surgery 3.4 (2017): 1099-1102.
  5. Sountoulides P., et al. “Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports”.Journal of Medical Case Reports 5 (2011): 429.
  6. Evgeniou E., et al. “Renal cell carcinoma metastasis to the paranasal sinuses and orbit”. BMJ Case Reports (2012): bcr0120125492.
  7. Capitanio U., et al. “Epidemiology of Renal Cell Carcinoma”. European Urology 1 (2019): 74-84.
  8. Mancini M., et al. “Gender-Related Approach to Kidney Cancer Management: Moving Forward”. International Journal of Molecular Sciences9 (2020): 3378.
  9. Rabjerg M., et al. “Incidental renal neoplasms: is there a need for routine screening? A Danish single-center epidemiological study". APMIS 8 (2014): 708-714.
  10. López F., et al. “Metastases to nasal cavity and paranasal sinuses”. Head Neck12 (2016): 1847-1854.
  11. Ali M., et al. “Diagnosis and management of benign tumors of nasal and paranasal cavities: 31 cases”. The Egyptian Journal of Otolaryngology 31 (2015): 4-9.
  12. Ralli M., et al. “Metastatic Renal Cell Carcinoma Presenting as a Paranasal Sinus Mass: The Importance of Differential Diagnosis”. Case Reports in Otolaryngology (2017): 5.
  13. Doğan S., et al. “The nasal septum: an unusual presentation of metastatic renal cell carcinoma”. Journal of Craniofacial Surgery 4 (2009): 1204-1206.
  14. Simo R., et al. “Metastatic renal cell carcinoma to the nose and paranasal sinuses”. Head Neck7 (2000): 722-727.
  15. Singh J., et al. “Occult renal cell carcinoma manifesting as nasal mass and epistaxis”. Reviews Urology 3 (2014): 145-148.
  16. Yücel ÖB., et al. “22-year survival following radical nephrectomy and several metastasectomies in a case of renal cell carcinoma”. Turkish Journal of Urology 2 (2017): 216-219.
  17. Ljungberg B., et al. “Eau guidelines on renal cell carcinoma” (2012)
  18. Dragomir A., et al. “Outcomes of complete metastasectomy in metastatic renal cell carcinoma patients: The Canadian Kidney Cancer information system experience”. Urologic Oncology 10 (2020): 799.e1-799.e10.
  19. Evropsko udruženje urologa Vodič za 2012 Udruženje Urologa Srbije (2012).
  20. Gong J., et al. “Metastasis in renal cell carcinoma: Biology and implications for therapy”. Asian Journal of Urology 4 (2016): 286-292.

Citation

Citation: Ivan Baljosevic., et al. “Nasal Septum Metastasis of Renal Cell Carcinoma 7 Years After Nephrectomy: A Case Report".Acta Scientific Orthopaedics 5.6 (2022): 34-38.

Copyright

Copyright: © 2022 Ivan Baljosevic., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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