Abstract

The study aims to study the difference in using antimicrobial prophylaxis for different durations in joints replacement operations and developing superficial surgical site infection.

A retrospective cohort study carried out in a well-equipped hospital, data collected from the record files of in-patient’s medical record unit and the outcome data was collected from consultant’s out- patient records and telephone calls.

Total sample size was 101, incidence of superficial site infection from the cohort was found to be 6.9% overall, (8.89% and 5.36% among those who took the antimicrobial for 24 hours and a week respectively). No association was found between the different duration of antimicrobial prophylaxis and having superficial surgical site infections (The risk ratio was 1.66 {confidence interval = 0.39 to 7.04}).

These results are consistent with the international results and current knowledge about the duration of administration of antimicrobial prophylaxis in joints replacement operation and clean surgical operations in general, as the 24 Hours use duration is supported by most of current results.

Keywords: Surgical Site; Infection; Sudan; Prophylaxis

References

1. Leslie Klenerman. “The evolution of Orthopedic Surgery, London, Royal Society of Medicine Press Ltd” (2002): 1-9.
2. Norman S Williams., et al. “Bailey and Love’s Short Practice of Surgery”. 25^th edition (2008).
3. Dale W Bratzler., et al. “Clinical practice guidelines for antimicrobial prophylaxis in surgery (American Society of Health-System Pharmacists ASHP report)”. American Journal of Health-System Pharmacy 70 (2013): 195-283.
4. Scottish Intercollegiate Guidelines Network (SIGN). Antibiotic prophylaxis in surgery, A national clinical guideline (2014).
5. Paulr Fortin., et al. “Outcomes of total hip and knee replacement”. Untied State, American College of Rheumatology (1998).
6. zharles Dardenn es and Jean-YvesReginster. “Health-Related Quality of Life in Total Hip and Total Knee Arthroplasty, Untied State”. The Journal of Bone and Joint Surgery 5 (2004): 963-974.
7. Al-Mulhim FA., et al. “Prevelence of Surgical Site Infection in Orthopedic surgery: 5 years analysis”. International Surgery3(2014): 264-268.
8. Purva Mathur., et al. “Implementation of a short course of prophylactic antibiotic treatment for prevention of postoperative infections in clean orthopaedic surgeries, India”. The Indian Journal of Medical Research 137.1 (2013): 111–116.
9. Brian Mawalla., et al. “Predictors of surgical site infections among patients undergoing major surgery at Bugando Medical Centre in Northwestern Tanzania”. BMC Surgery 11 (2011): 21.
10. Abdella AO Ahamed., et al. “Nasal Carriage of Staphyloccous Aurus and Epidemiology of Surgical Site Infection in a Sudanese University Hospital”. Journal of Clinical Microbiology12 (1998): 3614-3618.
11. Albur AL., et al. “post-discharge surveillance of wound infection by telephone-based call in a Sudanese Teaching Hospital”. Journal of Infectious Public Health5 (2013): 339-346.
12. Lovato C and Wagner JD. “Infection rates following perioperative prophylactic antibiotics versus postoperative extended regimen prophylactic antibiotics in surgical management of mandibular fractures”. Journal of Oral and Maxillofacial Surgery 4 (2009): 827-832.

Citation

Citation: Khalid Abdelsalam Mohamed Tahir and Asma Abdelaal Abdalla Osman. “Relationship between Antibiotic duration and Superficial Surgical Site Infection in Arthroplasty surgery, Khartoum, Sudan". Acta Scientific Orthopaedics 5.5 (2022): 17-22.

Copyright

Copyright: © 2022 Khalid Abdelsalam Mohamed Tahir and Asma Abdelaal Abdalla Osman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.