Acta Scientific Orthopaedics (ISSN: 2581-8635)

Research Article Volume 4 Issue 9

Management of Non-Healing Ulcers by Autologous Platelet Rich Fibrin (PRF)

Kartavya Chaudhari1,2,3, Parvez Ahmad Ganie1,2,3,4, Nilesh Kumar Agrawal5, Rashmi Jain6, Madhan Jeyaraman1,2,3,4* and Manish Khanna1,2,3,7

1Fellow in Orthopaedic Rheumatology, Dr. Ram Manohar Lohiya National Law University, Lucknow, Uttar Pradesh, India
2Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India
3Indian Orthopaedic Rheumatology Association (IORA), Lucknow, Uttar Pradesh, India
4Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India
5Department of Orthopaedics, JJM Medical College, Davangere, Karnataka, India
6Resident, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India
7Department of Orthopaedics, Prasad Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

*Corresponding Author: Madhan Jeyaraman, Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.

Received: July 23, 2021; Published: August 04, 2021


Introduction: Chronic non-healing ulcer is defined as a persistent defect in the skin for the period of more than six weeks and does not exhibit any tendency to heal following three or more months. Non-healing ulcers are enfeebling and leads to dwindling of quality life of a patient. Venous diseases, arterial diseases, and neuropathy are some of the common causes of these non-healing ulcers. The underlying pathology for chronic ulceration is multifactorial which calls for a patient’s systematic evaluation for the purpose of ascertaining etiology and optimization of the treatment. The therapeutic use of autologous platelet rich fibrin (PRF) represents a newer regenerative avenue to stimulate and accelerate complex wound healing. In this article, we aimed to treat the non-healing ulcers with platelet rich fibrin gel.

Materials and Methods: A total of 23 cases of non-healing ulcers were treated with autologous platelet rich fibrin gel once a week for 6 weeks and the final outcomes were analyzed.

Results: By the end of 4 months, almost 100% improvisation in the ulcer area and its volume was seen in 17 (73.91%) and 21 (91.30%) of the ulcers respectively.

Conclusion: Platelet rich fibrin gel provides biological treatment for non- healing ulcers by decreasing the morbidity and improving the functional quality of life.

Keywords: Non-Healing Ulcer; Platelet; Fibrin


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Citation: Madhan Jeyaraman., et al. “Management of Non-Healing Ulcers by Autologous Platelet Rich Fibrin (PRF)".Acta Scientific Orthopaedics 4.9 (2021): 03-08.


Copyright: © 2021 Madhan Jeyaraman., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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