Kartavya Chaudhari^1,2,3, Parvez Ahmad Ganie^1,2,3,4, Nilesh Kumar Agrawal⁵, Rashmi Jain⁶, Madhan Jeyaraman^1,2,3,4* and Manish Khanna^1,2,3,7

¹Fellow in Orthopaedic Rheumatology, Dr. Ram Manohar Lohiya National Law University, Lucknow, Uttar Pradesh, India
²Indian Stem Cell Study Group (ISCSG) Association, Lucknow, Uttar Pradesh, India
³Indian Orthopaedic Rheumatology Association (IORA), Lucknow, Uttar Pradesh, India
⁴Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India
⁵Department of Orthopaedics, JJM Medical College, Davangere, Karnataka, India
⁶Resident, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India
⁷Department of Orthopaedics, Prasad Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

*Corresponding Author: Madhan Jeyaraman, Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.

Received: July 23, 2021; Published: August 04, 2021

Abstract

Introduction: Chronic non-healing ulcer is defined as a persistent defect in the skin for the period of more than six weeks and does not exhibit any tendency to heal following three or more months. Non-healing ulcers are enfeebling and leads to dwindling of quality life of a patient. Venous diseases, arterial diseases, and neuropathy are some of the common causes of these non-healing ulcers. The underlying pathology for chronic ulceration is multifactorial which calls for a patient’s systematic evaluation for the purpose of ascertaining etiology and optimization of the treatment. The therapeutic use of autologous platelet rich fibrin (PRF) represents a newer regenerative avenue to stimulate and accelerate complex wound healing. In this article, we aimed to treat the non-healing ulcers with platelet rich fibrin gel.

Materials and Methods: A total of 23 cases of non-healing ulcers were treated with autologous platelet rich fibrin gel once a week for 6 weeks and the final outcomes were analyzed.

Results: By the end of 4 months, almost 100% improvisation in the ulcer area and its volume was seen in 17 (73.91%) and 21 (91.30%) of the ulcers respectively.

Conclusion: Platelet rich fibrin gel provides biological treatment for non- healing ulcers by decreasing the morbidity and improving the functional quality of life.

Keywords: Non-Healing Ulcer; Platelet; Fibrin

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Citation

Citation: Madhan Jeyaraman., et al. “Management of Non-Healing Ulcers by Autologous Platelet Rich Fibrin (PRF)".Acta Scientific Orthopaedics 4.9 (2021): 03-08.

Copyright

Copyright: © 2021 Madhan Jeyaraman., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.