Zheng Wuyan¹, Chen Jianchun², Lv Wanping³, Tan Wei⁴ and Oshmianska Nataliia¹*

¹Scientific Research Department, Chengdu Rheumatism Hospital, China
²Rheumatology Department 1, Chengdu Rheumatism Hospital, China
³Rheumatology Department, Chengdu Rheumatism Hospital, China
⁴Surgical Department, Chengdu Rheumatism Hospital, China

*Corresponding Author: Oshmianska Nataliia, Scientific Research Department, Chengdu Rheumatism Hospital, China.

Received: April 24, 2021; Published: May 11, 2021

Abstract

Introduction: Despite gout being widely known as the disease of old age, recent studies showed the rising problem of hyperuricaemia in children and young adults. Our aim was to analyze the factors influencing tophi formation in gout patients younger than 45 years old with major functional impairment of the joint.

Subjects and Methods: This study retrospectively analyzed medical records of 280 male patients between 18 and 80 years old (including 108 patients aged below 45) who were admitted in 2019-2020 with complains for major functional impairment of the joints and/or massive joint transformation and diagnosed with gout. The frequency of renal and hepatic disorders, presence of hepatic steatosis was assessed as well as lipid profile.

Results: Younger patients with disabling tophaceous gout have significantly higher serum uric acid compared to those aged above 60 and higher rate of hepatic steatosis, significantly higher triglycerides (2.62 ± 2.49 mmol/L compared to 1.75 ± 1.02) and higher total cholesterol. There was a trend for lower HDL cholesterol and higher LDL cholesterol (r = 0.116 and -0.119 respectively). Frequency of hypertriglyceridemia in younger gout patients was 39.81%, which is significantly higher compared to patients older than 60 (17.31%).

Conclusion: We found that young patients with tophaceous gout have significantly higher levels of hyperuricemia compared to patients older than 60. Rate of hepatic steatosis and dyslipidemia was also higher in younger patients, which may contribute to the development of metabolic syndrome and lead to tophi formation and major functional impairment of the joints in the very young age.

Keywords: Uric Acid; Hyperuricemia; Metabolic Syndrome; Gout; Hyperlipidemias; Gouty Arthritis

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Citation

Citation: Oshmianska Nataliia., et al. “Severe Hyperuricemia, Hepatic Steatosis and Dyslipidemia in Younger Patients with Tophaceous Gout". Acta Scientific Orthopaedics 4.6 (2021): 26-31.

Copyright

Copyright: © 2021 Oshmianska Nataliia., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.