Acta Scientific Orthopaedics (ISSN: 2581-8635)

Research Article Volume 3 Issue 12

The Effects of Leukocyte-Poor Platelet Rich Plasma for the Symptomatic Knee Osteoarthritis: A Single Centre Experience

Andrea Farneti1*, Michela Giustozzi2, Marta Micheli3, Enrico Sebastiani1, Michele Berloco1, Luca Pennacchi1, Carlo Farneti1 and Fabio Perrone1

1Orthopaedics and Traumatology Department, San Giovanni Battista Hospital, Foligno, Italy
2Internal Vascular and Emergency Medicine and Stroke Unit, University of Perugia, Perugia, Italy
3Transfusion Medicine Department San Giovanni Battista Hospital, Foligno, Italy

*Corresponding Author: Andrea Farneti, Orthopaedics and Traumatology Department, San Giovanni Battista Hospital, Foligno, Italy.

Received: November 05, 2020; Published: November 27, 2020

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Abstract

Purpose: Platelet-rich plasma (PRP) is routinely used in the symptomatic treatment of knee osteoarthritis (OA) despite limited evidence. The aim of this study was to evaluate the efficacy of injective protocol of leukocyte-poor-PRP for the symptomatic treatment of knee OA.

Methods: A retrospective study of 213 patients (a total of 326 knees treated) with symptomatic knee OA were analysed; each patient underwent a cycle of three infiltrations with intra-articular PRP and was re-evaluated at 3, 6 and 12 months with clinical examination or phone contact. The Visual Analog Scale (VAS) and International Knee Documentation Committee Subjective Knee Form (IKDC) were used to assess efficacy.

Results: Mean age was 68.1  ±  9.7 years and 59.6% were female. Mean VAS score before treatment was 6.5 ± 1.4 (range from 2 to 10), 1.6 ± 1.6 at 3 months, 1.4 ± 1.5 at 6 months and 1.7 ± 1.7 at 12 months. A significant reduction was observed between the VAS score pre-treatment and the VAS score at 3 months (p < 0.001), 6 months (p < 0.001) or 12 months (p < 0.001). The IKDC score was 41.7 ± 9.2 before treatment and was 67.3 ± 14.1 at 12 months (p < 0.001). A better symptomatic relief was observed in patients with early knee OA (stage 1 and 2 of Kellgren-Lawrence classification).

Conclusions: This study suggests that leukocyte-poor-PRP injections are effective in reducing pain symptoms and improving functional outcomes in patients with knee OA at short-term follow-up.

Keywords: Knee; Osteoarthritis; Platelet-rich-plasma; Pain; Conservative Treatment

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References

  1. Xing D., et al. “Intra-articular platelet-rich plasma injections for knee osteoarthritis: An overview of systematic reviews and risk of bias considerations”. International Journal of Rheumatic Diseases 11 (2017): 1612-1630.
  2. Wylde V., et al. “Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants”. Pain3 (2011): 566-572.
  3. Bennell KL., et al. “Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis”. Current Rheumatology Reports 5 (2017): 24.
  4. Belk JW., et al. “Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials”. American Journal of Sports Medicine (2020).
  5. Migliorini F., et al. “Comparison between intra-articular infiltrations of placebo, steroids, hyaluronic and PRP for knee osteoarthritis: a Bayesian network meta-analysis [published online ahead of print, 2020 Jul 28]”. Archives of Orthopaedic and Trauma Surgery (2020).
  6. Liumbruno G., et al. “Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Work Group. Recommendations for the transfusion of plasma and platelets”. Blood Transfus 2 (2009): 132-150.
  7. Laver L., et al. “PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies”. Cartilage4 (2017): 341-364.
  8. Pifer MA., et al. “Matrix metalloproteinase content and activity in low-platelet, low-leukocyte and high-platelet, high-leukocyte platelet rich plasma (PRP) and the biologic response to PRP by human ligament fibroblasts”. American Journal of Sports Medicine 5 (2014): 1211-1218.
  9. Braun HJ., et al. “The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy”. American Journal of Sports Medicine 5 (2014): 1204-1210.
  10. Dragoo JL., et al. “Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons”. American Journal of Sports Medicine 6 (2012): 1274-1281.
  11. Filardo G., et al. “Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach”. Knee Surgery, Sports Traumatology, Arthroscopy 10 (2012): 2082-2091.
  12. Cavallo C., et al. “Comparison of platelet-rich plasma formulations for cartilage healing: an In vitro study”. Journal of Bone and Joint Surgery American 5 (2014): 423-429.
  13. Kuffler DP. “Variables affecting the potential efficacy of PRP in providing chronic pain relief”. Journal of Pain Research 12 (2018): 109-116.
  14. Perut F., et al. “Preparation method and growth factor content of platelet concentrate influence the osteogenic differentiation of bone marrow stromal cells”. Cytotherapy7 (2013): 830-839.
  15. Kavadar G., et al. “Effectiveness of platelet-rich plasma in the treatment of moderate knee osteoarthritis: a randomized prospective study”. Journal of Physical Therapy Science 12 (2015): 3863-3867.
  16. Joshi Jubert N., et al. “Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial”. Orthopaedic Society for Sports Medicine 2 (2017): 2325967116689386.
  17. Kon E., et al. “PRP for the treatment of cartilage pathology”. The Open Orthopaedics Journal 7 (2013): 120-128.
  18. Roffi A., et al. “Does platelet-rich plasma freeze-thawing influence growth factor release and their effects on chondrocytes and synoviocytes?” BioMed Research International (2014): 692913.
  19. Sibbitt WL JR., et al. “Does ultrasound guidance improve the outcomes of arthrocentesis and corticosteroid injection of the knee?” Scandinavian Journal of Rheumatology 1 (2012): 66-72.
  20. Berkoff DJ., et al. “Clinical utility of ultrasound guidance for intra-articular knee injections: a review”. Clinical Interventions in Aging 7 (2012): 89-95.
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Citation

Citation: Andrea Farneti., et al. “The Effects of Leukocyte-Poor Platelet Rich Plasma for the Symptomatic Knee Osteoarthritis: A Single Centre Experience".Acta Scientific Orthopaedics 3.12 (2020): 52-57.




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