Acta Scientific Orthopaedics (ISSN: 2581-8635)

Case Report Volume 3 Issue 3

Tibial Osteomyelitis: A Case Report of Hyalohyphomycosis

Jahanavi M Ramakrishna1, Claudia R Libertin1*, Courtney E Sherman2 and Glenn G Shi2

1Division of Infectious Diseases, Mayo Clinic, Fl, USA
2Department of Orthopedic Surgery, Mayo Clinic, Fl, USA

*Corresponding Author: Claudia R Libertin, Division of Infectious Diseases, Mayo Clinic, Fl, USA.

Received: February 19, 2020; Published: February 24, 2020



  Microascus sp. has rarely been associated with invasive infections, and never reported as causing osteomyelitis. This report describes a rare case of tibial osteomyelitis due to hyalophomycosis in an immunocompetent patient with several comorbidities. Using advanced imaging and various microbiologic diagnostic techniques, Microascus was identified as the causative agent. The patient was managed with surgical debridement, delayed closure and antifungal pharmacotherapy. Microascus usually only progresses to invasive infection in immunocompromised patients and has yet to be reported as a cause of osteomyelitis.

Keywords: Microascus, Osteomyelitis, Hyalohyphomycosis



  1. Abbott Sean P., et al. “Microascus Brevicaulis Sp. Nov., the Teleomorph of Scopulariopsis Brevicaulis, Supports Placement of Scopulariopsis with the Microascaceae”. Mycologia 90.2 (1998): 297.
  2. Ajello L. “Hyalohyphomycosis and Phaeohyphomycosis: Two Global Disease Entities of Public Health Importance”. European Journal of Epidemiology 2.4 (1986): 243-251.
  3. Beltrame A., et al. “A Fatal Case of Invasive Fungal Sinusitis by Scopulariopsis Acremonium in a Bone Marrow Transplant Recipient”. International Journal of Infectious Diseases 13.6 (2009):  e488-e492.
  4. Bonifaz Alexandro., et al. “Onychomycosis by Molds. Report of 78 Cases”. European Journal of Dermatology 17.1 (2007): 70-72.
  5. De Pauw Ben., et al. “Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group”. Clinical Infectious Diseases 46.12 (2008): 1813-1821.
  6. Iwen PC., et al. “Utilization of the Internal Transcribed Spacer Regions as Molecular Targets to Detect and Identify Human Fungal Pathogens”. Medical Mycology 40.1 (2002): 87-109.
  7. Iwen Peter C., et al. “Invasive Scopulariopsis Brevicaulis Infection in an Immunocompromised Patient and Review of Prior Cases Caused by Scopulariopsis and Microascus Species”. Medical Mycology 50.6 (2012): 561-569.
  8. Kriesel JD., et al. “Invasive Sinonasal Disease Due to Scopulariopsis Candida: Case Report and Review of Scopulariopsosis”. Clinical Infectious Diseases 19.2 (1994): 317-319.
  9. Neglia Joseph P., et al. “Invasive Scopulariopsis in the Immunocompromised Host”. The American Journal of Medicine 83.6 (1987): 1163-1166.
  10. Ragge NK., et al. “A Case of Fungal Keratitis Caused by Scopulariopsis Brevicaulis: Treatment with Antifungal Agents and Penetrating Keratoplasty”. British Journal of Ophthalmology 74.9 (1990): 561-562.
  11. Sekhon AS., et al. “Deep Scopulariopsosis: A Case Report and Sensitivity Studies”. Journal of Clinical Pathology 27.10 (1974): 837-843.


Citation: Jahanavi M Ramakrishna., et al. "Tibial Osteomyelitis: A Case Report of Hyalohyphomycosis".Acta Scientific Orthopaedics 3.3 (2020): 23-26.


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