Kanishk Vishnoi¹*, Deepika Garg² and Prakash Nagpure³

¹Senior Resident, Department of ENT MGIMS Wardha, MUHS MBBS-GSVM, Kanpur, Hallet Hospital, UP, MS- MGIMS Wardha Maharashtra, India
²Professor, Department of ENT MGIMS Wardha, MUHS MBBS-MGIMS, Wardha Maharashtra, India
³Professor and Head Department of ENT, MGIMS Wardha, MUHS, MS-MGIMS Wardha, MBBS -MGIMS Wardha

*Corresponding Author: Kanishk Vishnoi, Senior Resident, Department of ENT MGIMS Wardha, MUHS MBBS-GSVM, Kanpur, Hallet Hospital, UP, MS- MGIMS Wardha Maharashtra, India.

Received: December 27, 2024; Published: January 18, 2025

Abstract

Background: Allergic rhinitis has a high disease burden and is more prevalent than estimated. Absolute eosinophil count is a marker for atopy in an otherwise healthy patient. Patients who tend to have a peripheral eosinophilia (raised absolute eosinophil count) such patients can be managed with ivermectin therapy which can not only reduce the absolute eosinophil count but also alleviate their symptoms.

Method: This study utilizes a pre-post study design in patients suffering from allergic rhinitis having peripheral eosinophilia without other confounders responsible for raised peripheral eosinophils. Taking absolute eosinophil count values as a reference point the results were analysed using paired t test.

Results: The Pre therapy absolute eosinophil count values are compared with post therapy value. Upon statistical analysis the result was significant. All the patients had improved symptoms and drop in the post deworming absolute eosinophil count.

Conclusion and Future Directions: Author concludes that patient with elevated absolute eosinophil count can be managed with deworming with ivermectin to alleviate the symptoms and reduce the absolute eosinophil count. Absolute eosinophilic count although has low sensitivity but can be used as a screening tool in patients of allergic rhinitis during management. Further research with more parameters such as pre-post ARIA score, serum Ig E value and nasal mucosa eosinophil count and RCT with placebo arm is warranted.

Keywords:Allergic Rhinitis; Deworming; Ivermectin; Absolute Eosinophil Count; Drug Repurposing

References

1. Nur Husna SM., et al. “Allergic Rhinitis: A Clinical and Pathophysiological Overview”. Frontiers in Medicine (Lausanne) 9 (2022): 874114.
2. John J., et al. “Association Between Severity of Allergic Rhinitis and Depression in Patients: A Cross-Sectional Study”. Cureus 5 (2023).
3. View of Serum IgE and Absolute Eosinophil Count in Allergic Rhinitis”. Tropical Journal of Pathology and Microbiology.
4. Demirjian M., et al. “Serum IgE and Eosinophil Count in Allergic Rhinitis”. Allergologia et Immunopathologia (Madr)5 (2012): 281-287.
5. Rasheed Z., et al. “Markers of Atopic Dermatitis and Allergic Rhinitis in Pediatrics”. Clinical and Molecular Allergy 1 (2018).
6. Nur Husna SM., et al. “Allergic Rhinitis: A Clinical and Pathophysiological Overview”. Frontiers in Medicine (Lausanne) 9 (2022): 874114.
7. John J., et al. “Evaluation of a Possible Association Between Severity of Allergic Rhinitis and the Level of Depression in Patients in a Tertiary Care Hospital in South India: A Cross-Sectional Study”. Cureus5 (2023).
8. Akanksha Agrawal., et al. “View of The diagnostic utility of Serum IgE and Absolute eosinophil count in cases of Allergic Rhinitis”. Tropical Journal of Pathology and Microbiology (2023).
9. Demirjian M., et al. “Serum IgE and eosinophil count in allergic rhinitis--analysis using a modified Bayes’ theorem”. Allergologia et Immunopathologia (Madr) 5 (2012): 281-287.
10. Rasheed Z., et al. “Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E”. Clinical and Molecular Allergy 1 (2018).
11. Eifan AO and Durham SR. “Pathogenesis of rhinitis”. Clinical and Experimental Allergy 9 (2016): 1139-1151.
12. Tefferi A. “Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment”. Mayo Clinic Proceedings 1 (2005): 75-83.
13. Sivaranjani M., et al. “A Study on the Significance of Nasal Smear Eosinophil Count and Blood Absolute Eosinophil Count in Patients with Allergic Rhinitis of Varied Severity of Symptoms”. Indian Journal of Otolaryngology and Head and Neck Surgery 4 (2023): 3449-3452.
14. Luo Q, Zhou S., et al. “Blood eosinophil count in the diagnosis of allergic-like rhinitis with chronic rhinosinusitis”. Clinical Otolaryngology 2 (2013): 339-346.
15. Endara P., et al. “Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity”. Clinical and Experimental Allergy 11 (2010): 1669-1677.
16. Rampur L., et al. “Effect of ivermectin on allergy-type manifestations in occult strongyloidiasis”. Annals of Allergy, Asthma and Immunology 4 (2016): 423-428.

Citation

Citation: Kanishk Vishnoi., et al. “Ivermectin in Allergic Rhinitis "a Single Arm Pre-Post Intervention Study"".Acta Scientific Otolaryngology 7.2 (2025): 08-12.

Copyright

Copyright: © 2025 Kanishk Vishnoi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.